INT52179

Context Info Confidence 0.61 First Reported 1993 Last Reported 2010 Negated 8 Speculated 6 Reported most in Body Documents 39 Total Number 45 Disease Relevance 25.40 Pain Relevance 18.32

lipid binding (Lbp) transport (Lbp) extracellular space (Lbp) extracellular region (Lbp)

Anatomy Link Frequency muscle 2 spinal 1 spine 1 trunk muscles 1 microglia 1 Lbp (Rattus norvegicus)

Pain Link Frequency Relevance Heat backache 832 100.00 Sciatic nerve 4 98.72 metalloproteinase 8 98.04 Lasting pain 56 97.60 Pain 273 96.48 rheumatoid arthritis 40 94.88 Analgesic 19 89.24 depression 13 85.32 Sciatica 6 82.64 Inflammation 40 79.12

Disease Link Frequency Relevance Heat Low Back Pain 858 100.00 Cognitive Disorder 36 99.98 Birth Weight 4 99.80 Aging 7 99.56 Sepsis 75 99.16 Ocular Hypertension 188 98.68 Pain 306 97.60 Neurodegenerative Disease 4 97.56 Injury 7 97.40 Nicotine Addiction 40 97.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Birth weight does not affect LBP and LBP does not affect the length of employment during pregnancy.

Neg (not) Regulation (affect) of LBP associated with birth weight and backache

1) Confidence 0.61 Published 2000 Journal J Obstet Gynaecol Section Abstract Doc Link 15512548 Disease Relevance 1.56 Pain Relevance 1.04

Among radiologic findings, level of distal fusion had no effect on the incidence or severity of LBP.

Neg (no) Regulation (effect) of LBP

2) Confidence 0.61 Published 2009 Journal Spine Section Body Doc Link 19752706 Disease Relevance 0 Pain Relevance 0

On the other hand, sagittal balance was a factor affecting LBP following scoliosis surgery.

Regulation (affecting) of LBP

3) Confidence 0.53 Published 2009 Journal Spine Section Body Doc Link 19752706 Disease Relevance 0 Pain Relevance 0

On the slit line, the result of regression analysis and interview suggested that exercises in the past affected the prevalence of LBP, and that aging and work made LBP worse.

Regulation (affected) of LBP associated with aging and backache

4) Confidence 0.53 Published 2004 Journal Sangyo Eiseigaku Zasshi Section Abstract Doc Link 15222430 Disease Relevance 0.95 Pain Relevance 0.92

A primary objective in this study is to evaluate the modulation of LBP on retinal microglia and its neuroprotective effect on survival of RGCs in a chronic ocular hypertension (OH) model.

Regulation (modulation) of LBP in microglia associated with ocular hypertension

5) Confidence 0.46 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.45 Pain Relevance 0.27

This is the first randomized trial to show positive influence on LBP beliefs in a primary prevention setting, and these findings have potentially important public health implications for prevention of LBP.

Regulation (influence) of LBP associated with backache

6) Confidence 0.45 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19418075 Disease Relevance 0.42 Pain Relevance 0.42

METHODS: A literature search was performed of MEDLINE, EMBASE, CINAHL, AMED, and PEDro, and from chosen systematic reviews investigating treatments that could plausibly affect recurrence of LBP.

Regulation (affect) of LBP

7) Confidence 0.45 Published 2009 Journal Spine Section Body Doc Link 19531986 Disease Relevance 0 Pain Relevance 0

Controlling for LBP frequency, all forms of health care utilization examined were associated with health beliefs.

Spec (examined) Regulation (Controlling) of LBP

8) Confidence 0.45 Published 1995 Journal Spine Section Body Doc Link 7747226 Disease Relevance 0 Pain Relevance 0

Finally, LBP does not appear to be an important factor affecting whether participants remained engaged in strenuous physical activity at baseline and follow-up or vice versa.

Spec (whether) Regulation (affecting) of LBP

9) Confidence 0.43 Published 2007 Journal Spine Section Body Doc Link 17202896 Disease Relevance 0 Pain Relevance 0

OBJECTIVE: To investigate the effect of glucosamine in patients with chronic LBP and degenerative lumbar OA.

Spec (investigate) Regulation (effect) of LBP

10) Confidence 0.39 Published 2010 Journal JAMA Section Body Doc Link 20606148 Disease Relevance 0.10 Pain Relevance 0

Cost utility analyses combined with randomized controlled trials for LBP were included.

Regulation (controlled) of LBP

11) Confidence 0.39 Published 2009 Journal Spine J Section Body Doc Link 19748833 Disease Relevance 0 Pain Relevance 0

Physical therapists and other health care providers have become more aware of these factors and their impact on the evaluation, treatment, and management of LBP.

Regulation (impact) of LBP associated with backache

12) Confidence 0.39 Published 1995 Journal Phys Ther Section Abstract Doc Link 7899485 Disease Relevance 0.95 Pain Relevance 0.87

The outcome measures were the changes in intensity of LBP, disability, self-evaluated future work ability, and neuromuscular fitness.

Regulation (changes) of LBP

13) Confidence 0.39 Published 2006 Journal Spine Section Body Doc Link 16915076 Disease Relevance 0 Pain Relevance 0

In this study, we found no effect of nonspecific physical exercise on recovery from LBP in men and women.

Neg (no) Regulation (effect) of LBP

14) Confidence 0.39 Published 2006 Journal Spine Section Body Doc Link 17173002 Disease Relevance 0 Pain Relevance 0

CONCLUSIONS: LBP frequency, health beliefs, and sociocultural factors influence health care behaviors and utilization among adults with a history of LBP in a society with universal access to health care.

Regulation (influence) of LBP

15) Confidence 0.39 Published 1995 Journal Spine Section Body Doc Link 7747226 Disease Relevance 0 Pain Relevance 0

Epidemiologic studies clearly indicate the role of mechanical loads on the etiology of occupational LBP.

Regulation (role) of LBP associated with backache

16) Confidence 0.39 Published 2002 Journal Annu Rev Biomed Eng Section Abstract Doc Link 12117750 Disease Relevance 0.65 Pain Relevance 0.65

OBJECTIVE: To investigate the possible effects of radiographic and other related parameters on LBP in patients underwent decompression and posterolateral instrumented fusion for degenerative lumbar spine disease.

Spec (possible) Regulation (effects) of LBP in spine

17) Confidence 0.39 Published 2010 Journal Spine Section Body Doc Link 20354466 Disease Relevance 0.10 Pain Relevance 0

Nevertheless, the relationship between psychological factors and LBP among cooks has not been explored in detail.

Neg (not) Regulation (explored) of LBP associated with backache

18) Confidence 0.37 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1971070 Disease Relevance 1.24 Pain Relevance 0.85

Beija et al. reported that playing sports had a protective effect against LBP [24].

Regulation (effect) of LBP associated with backache

19) Confidence 0.37 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1971070 Disease Relevance 1.82 Pain Relevance 1.27

Intravitreous injection of PBS did not affect the survival of RGCs in LBP-fed rats following induction of OH.

Neg (not) Regulation (affect) of LBP associated with ocular hypertension

20) Confidence 0.33 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.36 Pain Relevance 0

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