INT5219

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 47
Disease Relevance 23.35
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DBP)
Anatomy Link Frequency
blood 4
neurons 1
fibroblast 1
bands 1
heart 1
DBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 134 99.40 Very High Very High Very High
Analgesic 9 98.84 Very High Very High Very High
tolerance 10 97.84 Very High Very High Very High
nalbuphine 4 97.24 Very High Very High Very High
antagonist 52 96.56 Very High Very High Very High
beta blocker 93 95.36 Very High Very High Very High
headache 48 95.28 Very High Very High Very High
COX2 3 91.04 High High
Pain 64 91.00 High High
Perioperative pain 1 89.52 High High
Disease Link Frequency Relevance Heat
Hypertension 1068 99.76 Very High Very High Very High
Neuromyelitis Optica 162 99.68 Very High Very High Very High
Sepsis 4 99.42 Very High Very High Very High
Demyelinating Disease 142 99.40 Very High Very High Very High
Fabry Disease 384 99.28 Very High Very High Very High
Esophageal Disease 36 99.04 Very High Very High Very High
Stroke 338 99.00 Very High Very High Very High
Brain Hemorrhage 31 98.60 Very High Very High Very High
Myocardial Infarction 190 97.92 Very High Very High Very High
Frailty 7 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, amlodipine reduced ambulatory systolic (SBP) and DBP almost every hour over the whole circadian cycle, whereas the antihypertensive effect of captopril was attenuated during the final 3 hours of each dosing interval.
Negative_regulation (reduced) of DBP
1) Confidence 0.57 Published 1992 Journal J Hum Hypertens Section Abstract Doc Link 1293305 Disease Relevance 0.31 Pain Relevance 0.09
As add-on therapy (in 49% of HBP patients) to various background therapies, candesartan cilexetil consistently reduced mean SBP/DBP further, irrespective of the background therapy: diuretics (17.8/11.3 mm Hg), calcium antagonists (16.6/11.2 mm Hg), beta-blockers (16.5/ 10.4 mm Hg), ACE inhibitors (15.3/10.0 mm Hg), alpha-blockers (16.4/10.4 mm Hg).
Negative_regulation (reduced) of DBP associated with beta blocker, antagonist and hypertension
2) Confidence 0.57 Published 2001 Journal Am. J. Hypertens. Section Abstract Doc Link 11411737 Disease Relevance 1.00 Pain Relevance 0.21
Clinical BP data (Table 4) showed a significant reduction in SBP/DBP levels with amlodipine monotherapy compared with baseline; this reduction was greater after combination treatments.
Negative_regulation (reduction) of DBP
3) Confidence 0.42 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0.05 Pain Relevance 0
However, with the valsartan/amlodipine combination, the further mean reduction in BP (SBP/DBP: ?
Negative_regulation (reduction) of DBP
4) Confidence 0.42 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0 Pain Relevance 0
Candesartan cilexetil, as monotherapy (in 34% of ISH patients), reduced SBP/DBP by 17.0/4.4 mm Hg.
Negative_regulation (reduced) of DBP associated with hypertension
5) Confidence 0.42 Published 2001 Journal Am. J. Hypertens. Section Abstract Doc Link 11411737 Disease Relevance 1.12 Pain Relevance 0.29
As add-on therapy (in 66% of ISH patients) to various background therapies, candesartan cilexetil consistently reduced mean SBP/DBP further, irrespective of the background therapy: diuretics (17.4/5.1 mm Hg), calcium antagonists (15.6/3.6 mm Hg), beta-blockers (14.0/4.8 mm Hg), ACE inhibitors (13.4/4.3 mm Hg), and alpha-blockers (11.6/4.5 mm Hg).
Negative_regulation (reduced) of DBP associated with beta blocker, antagonist and hypertension
6) Confidence 0.42 Published 2001 Journal Am. J. Hypertens. Section Abstract Doc Link 11411737 Disease Relevance 1.01 Pain Relevance 0.31
These results indicate that excretion of urinary DBP is increased after long-term Cd exposure and that the loss of DBP in urine may be linked to renal tubular dysfunction and possibly bone lesions in the inhabitants of Cd-polluted areas.
Negative_regulation (loss) of DBP in urine
7) Confidence 0.38 Published 2007 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17347552 Disease Relevance 0.21 Pain Relevance 0.05
Other conditions such as septic shock may also be associated with reduced DBP levels and complex formation with actin [19].
Negative_regulation (reduced) of DBP associated with sepsis
8) Confidence 0.37 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.69 Pain Relevance 0.09
For these reasons, it is recommended that anesthesia for infantile Pompe patients specifically avoid propofol or high concentrations of sevoflurane and, instead, use an agent such as ketamine as the cornerstone for induction in order to better support coronary perfusion pressure and to avoid decreasing DBP with vasodilatory agents.


Negative_regulation (decreasing) of DBP
9) Confidence 0.36 Published 2007 Journal Paediatr Anaesth Section Body Doc Link 17596219 Disease Relevance 0 Pain Relevance 0
When compared with baseline values, SBP and DBP were decreased in women, whereas only DBP was decreased in men immediately before intubation (p < 0.05).
Negative_regulation (decreased) of DBP
10) Confidence 0.34 Published 2004 Journal J Clin Anesth Section Body Doc Link 15610835 Disease Relevance 0 Pain Relevance 0
When compared with baseline values, SBP and DBP were decreased in women, whereas only DBP was decreased in men immediately before intubation (p < 0.05).
Negative_regulation (decreased) of DBP
11) Confidence 0.34 Published 2004 Journal J Clin Anesth Section Body Doc Link 15610835 Disease Relevance 0 Pain Relevance 0
In healthy volunteers, a slight decrease in DBP occurred only with the 300 mg dose for sd and md (statistically not significant).
Negative_regulation (decrease) of DBP
12) Confidence 0.34 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717814 Disease Relevance 0.09 Pain Relevance 0
The mean maximum decrease in DBP was ?
Negative_regulation (decrease) of DBP
13) Confidence 0.30 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717814 Disease Relevance 0.09 Pain Relevance 0
In contrast, hypertensive patients showed a statistically significant reduction in DBP in doses of 100 mg to 400 mg at 2 hours and 50 mg to 400 mg at 12 hours after drug administration (p < 0.05; Figure 3).
Negative_regulation (reduction) of DBP associated with hypertension
14) Confidence 0.30 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717814 Disease Relevance 0.10 Pain Relevance 0
DBP was significantly reduced only at the higher dose level of 80 micrograms/kg.
Negative_regulation (reduced) of DBP
15) Confidence 0.29 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8839230 Disease Relevance 0.29 Pain Relevance 0.07
After i.v. infusion of ITF 296, blood pressure started to fall at the dose of 2 micrograms/kg/min, DBP being significantly reduced at doses above 1 microgram/kg/min.
Negative_regulation (reduced) of DBP in blood
16) Confidence 0.29 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8839230 Disease Relevance 0.35 Pain Relevance 0.09
Although the decreases in SDP and DBP persisted, the change in MAP was not statistically significant.
Negative_regulation (decreases) of DBP
17) Confidence 0.27 Published 1988 Journal Can J Anaesth Section Abstract Doc Link 3349553 Disease Relevance 0.14 Pain Relevance 0.31
Both before and during testosterone CLON lowered SBP, DBP and PR in HP to the same extent observed in NS.
Negative_regulation (lowered) of DBP
18) Confidence 0.26 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0.13 Pain Relevance 0.37
RESULTS: HR, SBP, DBP, and MAP were significantly decreased after propofol administration by 8.5%, 33%, 23%, and 26%, respectively, as compared with the pre-anesthesia control values.
Negative_regulation (decreased) of DBP
19) Confidence 0.26 Published 2010 Journal Acta Anaesthesiol Scand Section Body Doc Link 20236098 Disease Relevance 0 Pain Relevance 0
Furthermore, reducing DBP may actually decrease the risk of SBI irrespective of the type of index stroke (i.e. the most recent stroke at the time of randomization) (Hasegawa et al. 2004).
Negative_regulation (reducing) of DBP associated with brain hemorrhage and stroke
20) Confidence 0.25 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012553 Disease Relevance 1.71 Pain Relevance 0

General Comments

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