INT52196

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.42
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 3
neutrophil 2
lymphocytes 1
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 19 99.80 Very High Very High Very High
depression 4 99.28 Very High Very High Very High
cytokine 25 96.32 Very High Very High Very High
Inflammation 100 95.96 Very High Very High Very High
palliative 2 73.44 Quite High
fibrosis 1 68.48 Quite High
Arthritis 2 55.80 Quite High
chemokine 20 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 13 100.00 Very High Very High Very High
Depression 4 99.28 Very High Very High Very High
Lung Cancer 20 98.08 Very High Very High Very High
INFLAMMATION 106 96.56 Very High Very High Very High
Pulmonary Disease 144 95.52 Very High Very High Very High
Respiratory Disease 1 83.92 Quite High
Diarrhoea 2 82.32 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 81.88 Quite High
Appetite Loss 2 81.00 Quite High
Disease 13 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither anti-IL-6 antibody nor rhuIFN alpha had a direct growth-inhibitory effect on the AB22 mesothelioma cell line in vitro, however, in vivo rhuIFN alpha treatment of mice inoculated with AB22 cells attenuated both IL-6 mRNA expression in the tumours and serum IL-6 levels, ameliorated the depression of lymphocyte activities, and enhanced the number of tumour-infiltrating lymphocytes and macrophages.
Negative_regulation (attenuated) of Regulation (levels) of IL-6 in macrophages associated with lung cancer, depression and cancer
1) Confidence 0.42 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.10 Pain Relevance 0.17
Neither anti-IL-6 antibody nor rhuIFN alpha had a direct growth-inhibitory effect on the AB22 mesothelioma cell line in vitro, however, in vivo rhuIFN alpha treatment of mice inoculated with AB22 cells attenuated both IL-6 mRNA expression in the tumours and serum IL-6 levels, ameliorated the depression of lymphocyte activities, and enhanced the number of tumour-infiltrating lymphocytes and macrophages.
Negative_regulation (attenuated) of in lymphocytes Regulation (levels) of IL-6 in macrophages associated with lung cancer, depression and cancer
2) Confidence 0.14 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.10 Pain Relevance 0.17
SB239063 on the other hand reduces neutrophil infiltration and the concentrations of IL-6 and MMP-9 in BALF of rats after endotoxin inhalation, suggesting its potential as an antiinflammatory agent in COPD (Underwood et al 2000).
Negative_regulation (reduces) of Regulation (concentrations) of IL-6 in neutrophil associated with pulmonary disease, inflammation and metalloproteinase
3) Confidence 0.04 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.05 Pain Relevance 0.41

General Comments

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