INT52197

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.80
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 3
monocyte 2
Kupffer cell 2
lymphocytes 1
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 109 100.00 Very High Very High Very High
depression 4 97.80 Very High Very High Very High
Paracetamol 8 96.08 Very High Very High Very High
Infliximab 32 90.72 High High
Morphine 78 88.52 High High
palliative 2 70.48 Quite High
Inflammatory response 7 69.60 Quite High
Inflammation 114 67.16 Quite High
rheumatoid arthritis 40 62.76 Quite High
chemokine 12 45.72 Quite Low
Disease Link Frequency Relevance Heat
Cancer 14 99.68 Very High Very High Very High
Lung Cancer 20 98.08 Very High Very High Very High
Depression 4 97.80 Very High Very High Very High
Crystal Associated Disease 30 95.16 Very High Very High Very High
Injury 8 88.32 High High
Colitis 32 83.08 Quite High
Diarrhoea 3 82.32 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 81.88 Quite High
Appetite Loss 2 81.00 Quite High
Hepatotoxicity 1 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither anti-IL-6 antibody nor rhuIFN alpha had a direct growth-inhibitory effect on the AB22 mesothelioma cell line in vitro, however, in vivo rhuIFN alpha treatment of mice inoculated with AB22 cells attenuated both IL-6 mRNA expression in the tumours and serum IL-6 levels, ameliorated the depression of lymphocyte activities, and enhanced the number of tumour-infiltrating lymphocytes and macrophages.
Negative_regulation (attenuated) of Transcription (expression) of IL-6 in macrophages associated with lung cancer, depression and cancer
1) Confidence 0.43 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.10 Pain Relevance 0.16
The high IL-6-inducing activity found in samples before treatment was strongly reduced in samples obtained 4 hours after the first infusion, following TNF-?
Negative_regulation (reduced) of Transcription (found) of IL-6-inducing
2) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.12 Pain Relevance 0.28
Instead, Kupffer cell depletion by liposome/clodronate led to significant decreases in the levels of hepatic mRNA expression of several hepato-regulatory cytokines and mediators, including IL-6, IL-10, IL-18 binding protein and complement 1q, suggesting that Kupffer cells are a significant source for production of these mediators in this model.
Negative_regulation (decreases) of Transcription (expression) of IL-6 in Kupffer cell associated with cytokine
3) Confidence 0.30 Published 2002 Journal Chem. Res. Toxicol. Section Abstract Doc Link 12482232 Disease Relevance 0.37 Pain Relevance 0.58
D, whereas the decrease of IL-6 mRNA level in groups A and C (colitic animals
Negative_regulation (decrease) of Transcription (level) of IL-6
4) Confidence 0.28 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.33 Pain Relevance 0.11
It is, therefore, possible that the low level at 9 hours reflects an overall reduction of IL-6 transcription throughout the time course and that some elevation of IL-6 mRNA would still be detectable at the earlier time points in MSU-stimulated mice treated with the extracts.
Negative_regulation (reduction) of Transcription (transcription) of IL-6 associated with crystal associated disease
5) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.52 Pain Relevance 0.09
Neither anti-IL-6 antibody nor rhuIFN alpha had a direct growth-inhibitory effect on the AB22 mesothelioma cell line in vitro, however, in vivo rhuIFN alpha treatment of mice inoculated with AB22 cells attenuated both IL-6 mRNA expression in the tumours and serum IL-6 levels, ameliorated the depression of lymphocyte activities, and enhanced the number of tumour-infiltrating lymphocytes and macrophages.
Negative_regulation (attenuated) of in lymphocytes Transcription (expression) of IL-6 in macrophages associated with lung cancer, depression and cancer
6) Confidence 0.15 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.10 Pain Relevance 0.16
release, but only partially inhibited IL-6 and MCP-1 mRNA levels, suggesting the possibility that TNF-?
Negative_regulation (inhibited) of Transcription (levels) of IL-6
7) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.11 Pain Relevance 0.51
In parallel, the experiments were also performed by using the human monocyte cell line U937 and we found that U937 cells pre-treated with GTH also decreased the expression of IL-6 mRNA in a dose-dependent manner (data not shown).


Negative_regulation (decreased) of Transcription (expression) of IL-6 in monocyte
8) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2988746 Disease Relevance 0 Pain Relevance 0.15

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