INT52206

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Context Info
Confidence 0.46
First Reported 1995
Last Reported 2003
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.66
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl, Penk)
Anatomy Link Frequency
hypothalamus 4
neurons 2
Prl (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
agonist 1 71.76 Quite High
dopamine receptor 1 71.44 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 15 86.36 High High
Galactorrhea 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present observations suggest that the expression of enkephalin in TIDA neurons is PRL dependent and supported by sex steroids, primarily progesterone.
PRL Regulation (dependent) of Gene_expression (expression) of enkephalin in neurons associated with enkephalin
1) Confidence 0.46 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750466 Disease Relevance 0.07 Pain Relevance 0.65
Prolactin modulates hypothalamic preproenkephalin, but not proopiomelanocortin, gene expression during lactation.
Prolactin Regulation (modulates) of Gene_expression (expression) of preproenkephalin associated with enkephalin
2) Confidence 0.25 Published 2003 Journal Endocrine Section Title Doc Link 12668876 Disease Relevance 0.27 Pain Relevance 0.10
The aim of this study was to examine prolactin (PRL) regulation of preproenkephalin and proopiomelanocortin (POMC) gene expression in the hypothalamus during lactation.
PRL Spec (examine) Regulation (regulation) of Gene_expression (expression) of preproenkephalin in hypothalamus
3) Confidence 0.15 Published 2003 Journal Endocrine Section Abstract Doc Link 12668876 Disease Relevance 0.16 Pain Relevance 0
The aim of this study was to examine prolactin (PRL) regulation of preproenkephalin and proopiomelanocortin (POMC) gene expression in the hypothalamus during lactation.
prolactin Spec (examine) Regulation (regulation) of Gene_expression (expression) of preproenkephalin in hypothalamus
4) Confidence 0.15 Published 2003 Journal Endocrine Section Abstract Doc Link 12668876 Disease Relevance 0.16 Pain Relevance 0

General Comments

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