INT52212

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Context Info
Confidence 0.64
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.38
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp6) extracellular space (Bmp6) growth (Bmp6)
extracellular region (Bmp6) cytoplasm (Bmp6)
Anatomy Link Frequency
Schwann cells 2
Bmp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 12 100.00 Very High Very High Very High
cytokine 6 100.00 Very High Very High Very High
spinal inflammation 26 99.04 Very High Very High Very High
Inflammation 13 98.44 Very High Very High Very High
antagonist 4 75.00 Quite High
Neuritis 2 70.44 Quite High
spondylitis 1 50.00 Quite Low
Pain 3 25.00 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
spinal stenosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 2 99.22 Very High Very High Very High
Low Back Pain 28 99.04 Very High Very High Very High
Metastasis 3 98.96 Very High Very High Very High
Autoimmune Disease 2 98.76 Very High Very High Very High
Nervous System Inflammation 2 98.44 Very High Very High Very High
Reprotox - General 1 5 98.40 Very High Very High Very High
Cancer 6 97.04 Very High Very High Very High
Osteoporosis 5 93.16 High High
Ankylosis 4 92.72 High High
Heterotopic Ossification 7 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate expression of a TGF-beta-related bone morphogenetic protein, the vgr (BMP-6, DVR-6) in Schwann cells of the rat peripheral nervous system.
Gene_expression (expression) of BMP-6 in Schwann cells associated with peripheral nervous system
1) Confidence 0.64 Published 1995 Journal Glia Section Abstract Doc Link 7751058 Disease Relevance 0.17 Pain Relevance 0.44
Immunolocalization of vgr (BMP-6, DVR-6), a TGF-beta related cytokine, to Schwann cells of the rat peripheral nervous system: expression patterns are not modulated by autoimmune disease.
Gene_expression (expression) of BMP-6 in Schwann cells associated with autoimmune disease, peripheral nervous system and cytokine
2) Confidence 0.55 Published 1995 Journal Glia Section Title Doc Link 7751058 Disease Relevance 0.19 Pain Relevance 0.46
Arthritic synovial membranes have also been shown to express BMP-2 & BMP-6 and could influence cell turnover [13].
Gene_expression (express) of BMP-6 associated with arthritis
3) Confidence 0.29 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.39 Pain Relevance 0
BMPs are osteoinductive morphogens, and elevated expression of BMP-6 correlates with skeletal metastases of prostate cancer.
Gene_expression (expression) of BMP-6 associated with reprotox - general 1 and metastasis
4) Confidence 0.26 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548695 Disease Relevance 0.63 Pain Relevance 0.07
The levels of BMP-2, BMP-6, and BMP-7 are high in AS patients with BMP-2 involved in early stages and BMP-6 and BMP-7 in the later stages.19)
Gene_expression (levels) of BMP-6 associated with spinal inflammation
5) Confidence 0.22 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2981776 Disease Relevance 0.64 Pain Relevance 0.30
More importantly, arthritic synovial membranes have been shown to express BMP-2 and BMP-6 and can influence cell turnover [30].
Gene_expression (express) of BMP-6 associated with arthritis
6) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.34 Pain Relevance 0

General Comments

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