INT5223

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.74
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDP1) small molecule metabolic process (PDP1)
Anatomy Link Frequency
plasma 1
fat 1
muscle 1
PDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 7 96.20 Very High Very High Very High
Neurobehavioral 1 33.00 Quite Low
Neurotransmitter 1 32.08 Quite Low
Pain 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Insulin Resistance 12 98.84 Very High Very High Very High
Diabetes Mellitus 4 97.72 Very High Very High Very High
Lactic Acidosis 10 96.40 Very High Very High Very High
Toxicity 55 90.64 High High
Death 5 72.88 Quite High
Intellectual Impairment 1 67.92 Quite High
Convulsion 2 66.08 Quite High
Stress 29 62.68 Quite High
Ataxia 3 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have identified 14 additional patients with total PDH complex deficiency, all of whom were found to contain mutations within the PDHA1 gene (E(1)alpha subunit).
Negative_regulation (deficiency) of PDH
1) Confidence 0.41 Published 2004 Journal Am. J. Med. Genet. A Section Abstract Doc Link 15384102 Disease Relevance 0.24 Pain Relevance 0.09
To date, over 80 different mutations have been identified in the PDHA1 gene in patients with PDH complex deficiency, which are thus thought to contribute to the PDH deficient phenotype.
Negative_regulation (deficiency) of PDH
2) Confidence 0.41 Published 2004 Journal Am. J. Med. Genet. A Section Abstract Doc Link 15384102 Disease Relevance 0.19 Pain Relevance 0.10
Pyruvate dehydrogenase (PDH)-complex deficiency (OMIM 312170) is a clinically heterogeneous disorder, with phenotypes ranging from fatal lactic acidosis (LA) in the newborn to chronic neurological dysfunction.
Negative_regulation (deficiency) of PDH associated with anesthesia and lactic acidosis
3) Confidence 0.41 Published 2004 Journal Am. J. Med. Genet. A Section Abstract Doc Link 15384102 Disease Relevance 0.19 Pain Relevance 0.09
However, it has been suggested that elevated plasma free fatty acid (FFA) concentrations is the initial triggering event leading to downregulation of PDH (pyruvate dehydrogenase) activity and thus potentially contributing to insulin resistance (1).
Negative_regulation (downregulation) of PDH in plasma associated with insulin resistance
4) Confidence 0.40 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.19 Pain Relevance 0
Of notice is also that the same degree of repression of PDHa activity and PDH dephosphorylation changes was evident when muscle glycogen was lowered to 268 mmol/kg dry wt or plasma FFA was elevated to 714 ?
Negative_regulation (repression) of PDH in muscle associated with repression
5) Confidence 0.40 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.10 Pain Relevance 0
Thus, although there was no effect of elevated FFA on PDHa activity at rest in the present study, maybe due to the overnight high-fat diet in both trials, elevated FFA levels have been shown to induce insulin resistance (31,32), and individuals with enhanced circulating FFA levels like type 2 diabetic subjects may experience FFA-mediated insulin resistance at rest (33), potentially in part because of FFA-induced downregulation of PDH (1).
Negative_regulation (downregulation) of PDH in fat associated with diabetes mellitus and insulin resistance
6) Confidence 0.40 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.29 Pain Relevance 0
Three female patients are described with pyruvate dehydrogenase (PDH) deficiency as a result of mutation in the X-linked gene for the E1 alpha subunit of the complex.
Negative_regulation (deficiency) of PDH
7) Confidence 0.04 Published 1992 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 1293379 Disease Relevance 0.21 Pain Relevance 0.09
In a study by Schiller et al. [99] it was shown that arsenite can inhibit pyruvate dehydrogenase (PDH) activity through binding to vicinal dithiols in both the pure enzyme and tissue extract.
Negative_regulation (inhibit) of PDH
8) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2922724 Disease Relevance 0.34 Pain Relevance 0

General Comments

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