INT52233

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 6.39
Pain Relevance 11.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
spinal cord 4
medulla 2
liver 2
brain 2
kidney 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 2 99.80 Very High Very High Very High
Rostral ventrolateral medulla 14 99.68 Very High Very High Very High
agonist 33 99.60 Very High Very High Very High
Morphine 13 99.60 Very High Very High Very High
Nicotine 20 99.30 Very High Very High Very High
electroacupuncture 2 98.86 Very High Very High Very High
Hippocampus 25 98.68 Very High Very High Very High
Central nervous system 12 98.48 Very High Very High Very High
Spinal cord 45 98.12 Very High Very High Very High
Sciatic nerve 30 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 17 98.32 Very High Very High Very High
Hypotension 16 97.18 Very High Very High Very High
INFLAMMATION 18 97.04 Very High Very High Very High
Cv Unclassified Under Development 7 96.00 Very High Very High Very High
Injury 39 95.76 Very High Very High Very High
Convulsion 2 94.12 High High
Cancer 14 92.76 High High
Apoptosis 40 92.40 High High
Depression 10 91.92 High High
Neuropathic Pain 42 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.
Transcription (levels) of AP-1 in striatum
1) Confidence 0.66 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.03
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Transcription (level) of AP-1 in astrocytes
2) Confidence 0.55 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
Basal levels of AP-1 and opiate mRNAs were low in P7 hippocampus.
Transcription (levels) of AP-1 in hippocampus associated with hippocampus and opiate
3) Confidence 0.52 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.09 Pain Relevance 0.49
Reverse transcriptase-polymerase chain reactions were performed on total RNA from samples of the brain, heart, liver, and kidney to detect the expressions of c-fos and c-jun mRNAs.
Transcription (expressions) of jun in liver
4) Confidence 0.52 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10781476 Disease Relevance 0 Pain Relevance 0.26
Reverse transcriptase-polymerase chain reactions were performed on total RNA from samples of the brain, heart, liver, and kidney to detect the expressions of c-fos and c-jun mRNAs.
Transcription (detect) of jun in liver
5) Confidence 0.52 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10781476 Disease Relevance 0 Pain Relevance 0.26
In addition, PMA caused the induction of c-fos, c-jun and fra-1 mRNA level and, especially, PMA-induced increase of fra-1 mRNA level was further enhanced by CHX treatment at 4 h.
Transcription (level) of c-jun
6) Confidence 0.50 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Transcription (levels) of c-jun associated with nicotine
7) Confidence 0.48 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.48
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Transcription (levels) of c-jun in astrocytes
8) Confidence 0.48 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
KA administration markedly increased both c-fos and c-jun mRNA levels during 1 and 4 h and the increased levels of these proto-oncogene mRNA were further prolonged by the treatment with CHX.
Transcription (levels) of c-jun
9) Confidence 0.40 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.07
In addition, CHX alone increased both c-fos and c-jun mRNA levels although the onset times of induction were different.
Transcription (levels) of c-jun
10) Confidence 0.40 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.07
In contrast, a similar hypotensive response (-37+/-3.5 mm Hg) caused by the selective imidazoline I1 receptor agonist rilmenidine (25 microg) was associated with reduction in c-jun mRNA expression in the rostral ventrolateral medulla, but not in the NTS.
Transcription (expression) of c-jun in medulla associated with rostral ventrolateral medulla, hypotension and agonist
11) Confidence 0.37 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.52 Pain Relevance 0.61
Clonidine (0.5 microg), or alpha-methylnorepinephrine (alpha-MNE, 4 microg), a highly selective alpha2-adrenoceptor agonist, similarly reduced c-jun mRNA expression in the NTS and rostral ventrolateral medulla.
Transcription (expression) of c-jun in medulla associated with rostral ventrolateral medulla, agonist and clonidine
12) Confidence 0.37 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.50 Pain Relevance 0.56
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Transcription (levels) of c-jun associated with nicotine
13) Confidence 0.36 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.47
The sciatic nerve and the lumbar tract of the spinal cord were processed to evaluate the levels of the phosphorylated form of PKCgamma, ERK 1,2, SAP/JNK, p-38 and c-Jun; furthermore, the mRNA expression of the early genes c-Jun and c-Fos has been investigated.
Transcription (expression) of c-Jun in spinal cord associated with sciatic nerve and spinal cord
14) Confidence 0.36 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.57 Pain Relevance 0.57
Several of these factors stimulate a cascade of MAP kinases and PKC and potently activate the transcription factors AP-1 and NF-kB, which are involved in MMP and adhesion molecule expression [39,40].
Transcription (transcription) of AP-1 associated with adhesions
15) Confidence 0.30 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.76 Pain Relevance 0.15
Like other transcription factors, such as AP-1 proteins, c-fos, and c-Jun, phosphorylated CREB may participate in the downstream signal transduction cascade in the longer lasting changes in synaptic plasticity.
Transcription (transcription) of c-Jun
16) Confidence 0.28 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.43 Pain Relevance 0.71
At the transcriptional level c-Jun mRNA was increased in the ipsilateral side of spinal cord of CCI saline-treated rats, whereas c-Fos mRNA was unchanged.
Transcription (transcriptional) of c-Jun in spinal cord associated with spinal cord
17) Confidence 0.26 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.52 Pain Relevance 0.67
At the transcriptional level c-Jun mRNA was increased in the ipsilateral side of spinal cord of CCI saline-treated rats, whereas c-Fos mRNA was unchanged.
Transcription (level) of c-Jun in spinal cord associated with spinal cord
18) Confidence 0.26 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.52 Pain Relevance 0.67
Using the techniques of immunohistochemistry, Northern blotting and in situ hybridization, we have found that electroacupuncture (2/15Hz) accelerated the expression of mRNA and protein synthesis of immediate early genes c-fos, c-jun as well as proenkephalin gene in rat central nervous system (CNS).
Transcription (synthesis) of c-jun in CNS associated with central nervous system and electroacupuncture
19) Confidence 0.24 Published 1995 Journal Sheng Li Ke Xue Jin Zhan Section Abstract Doc Link 8584889 Disease Relevance 0 Pain Relevance 0.26
Indeed, PGE2 failed to up-regulate c-jun mRNA expression as well as its protein product.
Transcription (expression) of c-jun in PGE2
20) Confidence 0.23 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9757037 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox