INT52253

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.36
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Amph) cytoplasm (Amph)
Anatomy Link Frequency
neurons 2
cerebral cortex 1
brain 1
Amph (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 1 99.24 Very High Very High Very High
cerebral cortex 2 98.90 Very High Very High Very High
anesthesia 8 97.06 Very High Very High Very High
Dopamine 309 96.48 Very High Very High Very High
agonist 3 96.20 Very High Very High Very High
dopamine receptor 1 95.88 Very High Very High Very High
substance P 6 92.52 High High
isoflurane 7 92.12 High High
Versed 1 88.24 High High
Eae 6 86.40 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 18 90.40 High High
Body Weight 1 89.20 High High
Drug Dependence 6 65.44 Quite High
Apoptosis 4 57.76 Quite High
Opiate Addiction 3 29.16 Quite Low
Appetite Loss 3 12.00 Low Low
Amphetamine Dependence 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, systemic scopolamine blocks, whereas oxotremorine augments, AMPH-stimulated preproenkephalin (PPE) gene expression in striatopallidal neurons.
Gene_expression (expression) of AMPH in neurons
1) Confidence 0.49 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067445 Disease Relevance 0 Pain Relevance 0.46
These results demonstrate a clear dose-related responsiveness of zif/268 and preprodynorphin gene expression in cortical and/or striatal neurons that is positively correlated with a dose-dependent motor-stimulating effect of AMPH and METH.
Gene_expression (expression) of AMPH in neurons
2) Confidence 0.47 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7752096 Disease Relevance 0 Pain Relevance 0.13
In saline-treated rats, ejection of AMPH (400 ?
Gene_expression (ejection) of AMPH
3) Confidence 0.44 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.05 Pain Relevance 0.39
M/100 nl) 2 min before AMPH infusion (400 ?
Gene_expression (infusion) of AMPH
4) Confidence 0.44 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.34
cells by STZ in rats is a model of insulin depletion, and as such, we hypothesized that PI3K signaling in the brain, as well as DAT cell surface expression and possibly DAT-mediated behavioral effects of AMPH, would be reduced following STZ pretreatment.
Gene_expression (expression) of AMPH in brain
5) Confidence 0.39 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.09 Pain Relevance 0.35
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Gene_expression (levels) of amphiphysin in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
6) Confidence 0.38 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53

General Comments

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