INT52256

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 0.42
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Amph) cytoplasm (Amph)
Anatomy Link Frequency
plasma 3
NAc 1
neurons 1
striatum 1
Amph (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 723 100.00 Very High Very High Very High
cocaine 28 98.76 Very High Very High Very High
Nucleus accumbens 16 98.20 Very High Very High Very High
agonist 1 97.64 Very High Very High Very High
Eae 14 93.80 High High
imagery 35 91.92 High High
Neurotransmitter 14 71.84 Quite High
addiction 14 64.88 Quite High
cerebral cortex 1 63.04 Quite High
Opioid 8 52.84 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 42 99.04 Very High Very High Very High
Appetite Loss 7 91.32 High High
Drug Dependence 14 64.88 Quite High
Hyperglycemia 7 44.72 Quite Low
Congenital Anomalies 7 25.28 Quite Low
Amphetamine Dependence 7 25.00 Low Low
Opiate Addiction 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 7 5.00 Very Low Very Low Very Low
Decapitation 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons.
Negative_regulation (inhibition) of AMPH in NAc associated with nucleus accumbens
1) Confidence 0.38 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9756360 Disease Relevance 0 Pain Relevance 0.48
These results demonstrate a clear dose-related responsiveness of zif/268 and preprodynorphin gene expression in cortical and/or striatal neurons that is positively correlated with a dose-dependent motor-stimulating effect of AMPH and METH.
Negative_regulation (effect) of AMPH in neurons
2) Confidence 0.33 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7752096 Disease Relevance 0 Pain Relevance 0.12
Importantly, Galici et al. [12] showed that there is a selective decrease in AMPH self-administration in diabetic rats, consistent with data showing that dopamine uptake is decreased in hypoinsulinemic rats [14,30].
Negative_regulation (decrease) of AMPH associated with dopamine and diabetes mellitus
3) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.42 Pain Relevance 0.33
Recently, we have shown that AMPH self-administration is reduced in rats that have been depleted of insulin with the diabetogenic agent streptozotocin (STZ).
Negative_regulation (reduced) of AMPH
4) Confidence 0.28 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.22
To evaluate whether the reduction in AMPH-induced DA efflux caused by hypoinsulinemic conditions is promoted by a decrease in DAT cell surface expression, we evaluated DAT levels at the plasma membrane in striatal synaptosomes from rats made hypoinsulinemic with STZ [13].
Spec (whether) Negative_regulation (reduction) of AMPH-induced in plasma associated with dopamine
5) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.21
Collectively these data support the hypothesis that hypoinsulinemia, by downregulation of PI3K signaling (see Figure 3), significantly reduces AMPH-induced DA efflux because of reduced DAT plasma membrane expression.
Negative_regulation (reduces) of AMPH-induced in plasma associated with dopamine
6) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.45
These findings, together with our electrochemical data (Figures 2 and 3), support the hypothesis that the reduction in AMPH-induced DA efflux caused by STZ treatment is a consequence of a reduction in DAT levels on the plasma membrane and are consistent with the previously reported blunted behavioral properties of AMPH under hypoinsulinemic conditions [12,33,34,51].


Negative_regulation (reduction) of AMPH-induced in plasma associated with dopamine
7) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.22
These data suggest that under hypoinsulinemic conditions, in which PI3K signaling is diminished, the ability of AMPH to cause DA efflux is impaired, possibly by decreasing DAT function.


Spec (possibly) Negative_regulation (impaired) of AMPH associated with dopamine
8) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.61
Importantly, selective inhibition of PI3K with LY294002 within the striatum results in a profound reduction in the subsequent potential for AMPH to evoke DA efflux.
Negative_regulation (reduction) of AMPH in striatum associated with dopamine
9) Confidence 0.28 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.30

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