INT52264

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 180
Total Number 182
Disease Relevance 90.87
Pain Relevance 51.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
neurons 18
T cells 14
plasma 9
lung 5
macrophages 4
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5191 100.00 Very High Very High Very High
Inflammation 2561 100.00 Very High Very High Very High
chemokine 542 100.00 Very High Very High Very High
antagonist 482 100.00 Very High Very High Very High
Enkephalin 38 100.00 Very High Very High Very High
opioid receptor 15 100.00 Very High Very High Very High
melanocortin 1 receptor 7 100.00 Very High Very High Very High
Morphine 2 99.98 Very High Very High Very High
psoriasis 161 99.88 Very High Very High Very High
Spinal cord 107 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2750 100.00 Very High Very High Very High
Syndrome 94 100.00 Very High Very High Very High
Herpes Simplex Virus 1677 99.96 Very High Very High Very High
Cancer 1649 99.96 Very High Very High Very High
Eosinophilia 230 99.96 Very High Very High Very High
Psoriasis 181 99.88 Very High Very High Very High
Ulcers 29 99.84 Very High Very High Very High
Injury 159 99.80 Very High Very High Very High
Reprotox - General 1 63 99.76 Very High Very High Very High
Necrosis 120 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, findings from several laboratories have demonstrated the impact of opioid treatment on antibody responses, and the molecular basis for this effect is likely due, at least in part, to the modulation of both cytokine and cytokine receptor expression.
Gene_expression (expression) of cytokine associated with opioid and cytokine
1) Confidence 0.77 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245967 Disease Relevance 0.23 Pain Relevance 0.76
Measures included past sun exposure by calendar and questionnaire, spectrophotometric skin type, and MC1R genotype, with any MC1R Arg151Cys, Arg160Trp, or Asp294His alleles present denoted as red hair color (RHC) variant.
Gene_expression (present) of red in skin
2) Confidence 0.65 Published 2008 Journal Neurology Section Body Doc Link 18711112 Disease Relevance 0.17 Pain Relevance 0
We have established a serum free human melanocyte-keratinocyte coculture system to study the behavior and functional abilities of melanocytes expressing MC1R red hair color (RHC) variants in order to identify differences from their wild type (WT) counterparts.
Gene_expression (expressing) of red in hair associated with melanocortin 1 receptor
3) Confidence 0.58 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 17960564 Disease Relevance 0.15 Pain Relevance 0.39
The mineral and collagen element are probably preserved in their original form by refrigeration; practically all the cellular elements die, just as they do in fresh grafts.
Gene_expression (preserved) of collagen element
4) Confidence 0.57 Published 2008 Journal Clin Orthop Relat Res Section Body Doc Link PMC2505281 Disease Relevance 0.07 Pain Relevance 0
Moreover, findings from several laboratories have demonstrated the impact of opioid treatment on antibody responses, and the molecular basis for this effect is likely due, at least in part, to the modulation of both cytokine and cytokine receptor expression.
Gene_expression (expression) of cytokine associated with opioid and cytokine
5) Confidence 0.52 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245967 Disease Relevance 0.23 Pain Relevance 0.77
New information from studies on the inflammatory response in expressed prostatic secretion in patients with chronic pelvic pain syndrome and in bladder tissue from patients with interstitial cystitis indicates that complex systems on the cytokine gene expression level may be operating in these diseases.
Gene_expression (expression) of cytokine gene in bladder associated with inflammatory response, pain pelvic, disease, interstitial cystitis, chronic pelvic pain syndrome and cytokine
6) Confidence 0.42 Published 2002 Journal Curr Opin Urol Section Abstract Doc Link 11753136 Disease Relevance 1.43 Pain Relevance 1.01
The osteogenic differentiation was confirmed by Alizarin Red S staining and Alkaline Phosphatase assay.
Gene_expression (staining) of Red
7) Confidence 0.26 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.07 Pain Relevance 0
Ik proteins are expressed by both proliferating (BrdU+/nestin+) and by post-mitotic differentiating (MAP2+) cells in the developing striatum between embryonic day 12 and post-natal day 2 and mRNAs encoding for the Ik and ENK genes are co-expressed by a subset of differentiating striatal neurons.
Gene_expression (expressed) of Ik in neurons associated with enkephalin
8) Confidence 0.23 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.57
During our search for transcription factors that control the developmental expression of the enkephalin (ENK) gene we found that Ik-1 and Ik-2 isoforms are specifically expressed in the embryonic striatum and bind the Ik-like cis-regulatory DNA element present on the ENK gene.
Gene_expression (expressed) of Ik in striatum associated with enkephalin
9) Confidence 0.23 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.48
During our search for transcription factors that control the developmental expression of the enkephalin (ENK) gene we found that Ik-1 and Ik-2 isoforms are specifically expressed in the embryonic striatum and bind the Ik-like cis-regulatory DNA element present on the ENK gene.
Gene_expression (expressed) of Ik in striatum associated with enkephalin
10) Confidence 0.23 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.48
Ik proteins are expressed by both proliferating (BrdU+/nestin+) and by post-mitotic differentiating (MAP2+) cells in the developing striatum between embryonic day 12 and post-natal day 2 and mRNAs encoding for the Ik and ENK genes are co-expressed by a subset of differentiating striatal neurons.
Gene_expression (co-expressed) of Ik in neurons associated with enkephalin
11) Confidence 0.20 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.66
Alizarin Red S staining
Gene_expression (staining) of Alizarin Red S
12) Confidence 0.17 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1904213 Disease Relevance 0.08 Pain Relevance 0.04
CONCLUSION: There is a distinct cytokine gene expression profile in neutrophils at the THA surgical wound site at 24 h postsurgery when compared with that found in presurgery circulating neutrophils.
Gene_expression (expression) of cytokine gene in neutrophils
13) Confidence 0.15 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690273 Disease Relevance 0.05 Pain Relevance 0
In the red region,O2Hb absorbs less light than Hb, while the reverse occurs in theinfrared region.
Gene_expression (region) of red
14) Confidence 0.14 Published 1999 Journal Crit Care Section Body Doc Link PMC137227 Disease Relevance 0 Pain Relevance 0
Cytokine gene expression after total hip arthroplasty: surgical site versus circulating neutrophil response.
Gene_expression (expression) of Cytokine gene in hip associated with cytokine
15) Confidence 0.13 Published 2009 Journal Anesth. Analg. Section Title Doc Link 19690273 Disease Relevance 0.36 Pain Relevance 0.50
We sought to better understand the contribution of neutrophils to cytokine/chemokine gene expression at the surgical wound site during the initial postsurgery phase of total hip arthroplasty (THA).
Gene_expression (expression) of cytokine in hip associated with chemokine, injury and cytokine
16) Confidence 0.13 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19690273 Disease Relevance 0.46 Pain Relevance 0.45
In both conditions (upright–RED and upright–LED, Fig. 8B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand (mean ?
Gene_expression (upright) of RED in neurons
17) Confidence 0.13 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
Mean ± SD differences in preferred directions of all neurons tested during upright and RED in the counterclockwise (CCW) and clockwise (CW) directions were ?
Gene_expression (tested) of RED in neurons
18) Confidence 0.13 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
In both conditions (upright–RED and upright–LED, Fig. 8B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand (mean ?
Gene_expression (upright) of RED in neurons
19) Confidence 0.13 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
However, in both RED and LED conditions (Figs 6B, 7B, and 8B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand and upright and LED on the other in all 3 task conditions tested (smooth pursuit only, optic flow only, and smooth pursuit + optic flow; Figs 6B, 7B, and 8B, also Table 2A–C).
Gene_expression (upright) of RED in optic
20) Confidence 0.13 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0

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