INT5228

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 38
Speculated 30
Reported most in Abstract
Documents 934
Total Number 965
Disease Relevance 209.80
Pain Relevance 503.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
neurons 73
spinal cord 67
brain 60
nucleus 46
spinal 31
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1672 100.00 Very High Very High Very High
Pain 1488 100.00 Very High Very High Very High
Morphine 1427 100.00 Very High Very High Very High
Dorsal horn 959 100.00 Very High Very High Very High
qutenza 932 100.00 Very High Very High Very High
Dopamine 858 100.00 Very High Very High Very High
antagonist 854 100.00 Very High Very High Very High
Inflammation 834 100.00 Very High Very High Very High
withdrawal 565 100.00 Very High Very High Very High
cocaine 419 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1440 100.00 Very High Very High Very High
INFLAMMATION 843 100.00 Very High Very High Very High
Nociception 801 100.00 Very High Very High Very High
Stress 756 100.00 Very High Very High Very High
Urological Neuroanatomy 402 100.00 Very High Very High Very High
Anxiety Disorder 141 100.00 Very High Very High Very High
Disease 56 100.00 Very High Very High Very High
Hemorrhage 44 99.98 Very High Very High Very High
Anaphylaxis 17 99.98 Very High Very High Very High
Frailty 46 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increases in both immunocytochemical detection of Fos and conditioned place aversion were seen at doses >/= 7.5 microg/kg.
Positive_regulation (increases) of Fos
1) Confidence 0.70 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11120397 Disease Relevance 0 Pain Relevance 1.26
BACKGROUND: It has been proposed that the measure of noxious stimulus-induced Fos (the protein product of the immediate early gene c-fos) expression in the spinal cord dorsal horn of laboratory animals may provide an estimate of the potential of specific treatments to produce preemptive analgesia.
Positive_regulation (induced) of Fos in spinal cord dorsal horn associated with dorsal horn, preemptive analgesia and spinal cord
2) Confidence 0.70 Published 1998 Journal Anesthesiology Section Abstract Doc Link 9447868 Disease Relevance 0.07 Pain Relevance 0.51
In the 4-Hz-treated group, significant increases in Fos labeling were also observed in the cuneiform nucleus, dorsal and laterodorsal subdivisions of the periaqueductal gray, habenular nucleus, arcuate hypothalamic nucleus, and the lateroventral and lateral hypothalamic nuclei as compared to non-stimulated controls.
Positive_regulation (increases) of Fos in nucleus associated with central grey
3) Confidence 0.70 Published 1993 Journal Pain Section Abstract Doc Link 8446432 Disease Relevance 0.19 Pain Relevance 1.17
A significantly increased Fos immunoreactivity was found in the trigeminal nucleus caudalis (layers I and II), the area postrema, the nucleus of the solitary tract, the parvicellular reticular nucleus, the locus coeruleus, the parabrachial nucleus and the raphe nuclei.
Positive_regulation (increased) of Fos in parabrachial nucleus associated with locus ceruleus, raphe and parabrachial
4) Confidence 0.70 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11843868 Disease Relevance 0.62 Pain Relevance 0.89
We found an increase in distention-induced Fos in preshocked rats in the nucleus tractus solitarius and a weaker effect in the central nucleus of the amygdala.
Positive_regulation (increase) of Fos in nucleus associated with amygdala
5) Confidence 0.70 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882806 Disease Relevance 0.29 Pain Relevance 0.12
We found an increase in distention-induced Fos in preshocked rats in the nucleus tractus solitarius and a weaker effect in the central nucleus of the amygdala.
Positive_regulation (induced) of Fos in nucleus associated with amygdala
6) Confidence 0.70 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882806 Disease Relevance 0.29 Pain Relevance 0.12
The largest and most significant increase in Fos immunoreactivity was found in the ventrolateral column (especially in its caudal part), whereas only a moderate increase was found in the lateral column.
Positive_regulation (increase) of Fos in lateral column
7) Confidence 0.70 Published 1997 Journal Neuroscience Section Abstract Doc Link 9135098 Disease Relevance 0.84 Pain Relevance 0.29
The plume-shaped region of drug-induced increase in Fos immunoreactivity immediately surrounding a morphine microinjection site (Fos plume) was objectively mapped.
Positive_regulation (increase) of Fos in plume associated with morphine
8) Confidence 0.70 Published 2000 Journal Brain Res. Section Abstract Doc Link 10773195 Disease Relevance 0 Pain Relevance 0.73
To test this we injected morphine (0.12, 0.60, 3.0 microg/injection) directly into the hindpaw (intraplantar) of infant rats at 3, 10 and 21 days of age, and assessed the behavioral response and the induction of Fos like immunocytochemistry in the dorsal horn of the spinal cord in the formalin test.
Positive_regulation (induction) of Fos in spinal cord associated with dorsal horn, spinal cord and morphine
9) Confidence 0.70 Published 1999 Journal Pain Section Abstract Doc Link 10353503 Disease Relevance 0.08 Pain Relevance 1.02
The increased Fos was distributed within 400 microm from the edge of the microdialysis fiber.
Positive_regulation (increased) of Fos in edge
10) Confidence 0.70 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683575 Disease Relevance 0 Pain Relevance 0.36
Since many other substances which are related to pain mechanisms can be induced by Fos, it is suggested that nitric oxide may regulate production of these substances through activation of Fos.
Positive_regulation (activation) of Fos associated with pain
11) Confidence 0.70 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683575 Disease Relevance 0.19 Pain Relevance 0.41
Fos protein, an indicator of neuronal activity after noxious stimulation, is upregulated after formalin injection.
Positive_regulation (upregulated) of Fos in neuronal
12) Confidence 0.70 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 11812713 Disease Relevance 0.10 Pain Relevance 0.61
Induction of Fos protein-like immunoreactivity in the trigeminal spinal nucleus caudalis and upper cervical cord following noxious and non-noxious mechanical stimulation of the whisker pad of the rat with an inferior alveolar nerve transection.
Positive_regulation (Induction) of Fos in spinal associated with inferior alveolar nerve and peripheral arterial disease
13) Confidence 0.70 Published 2002 Journal Pain Section Title Doc Link 11839422 Disease Relevance 0.48 Pain Relevance 0.25
Using immunohistochemical staining of Fos, the present results indicate that morphine withdrawal induced marked Fos immunoreactivity (Fos-IR) within the cardiomyocyte nuclei.
Positive_regulation (induced) of Fos immunoreactivity in cardiomyocyte associated with withdrawal and morphine
14) Confidence 0.70 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15249992 Disease Relevance 0.05 Pain Relevance 1.14
The induction of c-Fos protein--a product of the c-fos gene, a marker of changes in neuronal activity, was studied in brain structures of animals differing in their sensitivity to the acute painful stimulation, a foot-shock (MS--more sensitive rats; LS--less sensitive rats, according to the arbitrary criterion in the flinch-jump pretest).
Positive_regulation (induction) of c-Fos protein in neuronal associated with pain and shock
15) Confidence 0.70 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15489021 Disease Relevance 0.17 Pain Relevance 0.17
The protein Fos is a transcription factor which is quickly induced in response to a variety of extracellular signals.
Positive_regulation (induced) of Fos
16) Confidence 0.70 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300404 Disease Relevance 0.06 Pain Relevance 0.07
Scopolamine, a muscarinic antagonist, induced Fos in both striosomal and matrix compartments in the striatum.
Positive_regulation (induced) of Fos in striatum associated with antagonist
17) Confidence 0.70 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 8281324 Disease Relevance 0 Pain Relevance 0.59
This suggests that the induction of Fos provoked by oxotremorine does not involve dopamine, glutamate or opiates.
Positive_regulation (induction) of Fos associated with glutamate, dopamine and opiate
18) Confidence 0.70 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 8281324 Disease Relevance 0 Pain Relevance 0.64
Thus, while GC stimulation of Fos suggests activation of neurons involved in sympathetic outflow and/or pain, down-regulation of NADPH-d indicates attenuation of nociceptive outflow, considering the role of enzyme-derived nitric oxide in pain-related mechanisms.
Positive_regulation (stimulation) of Fos in outflow associated with nociception and pain
19) Confidence 0.70 Published 2001 Journal Brain Res. Section Abstract Doc Link 11532430 Disease Relevance 0.81 Pain Relevance 0.44
In this study, we examined whether the intraperitoneal injections of lidocaine at doses inducing convulsions within 10 min, increased the level of c-fos mRNA and protein in forebrain areas.
Spec (whether) Positive_regulation (increased) of c-fos mRNA in forebrain associated with convulsion and lidocaine
20) Confidence 0.70 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10604276 Disease Relevance 0.32 Pain Relevance 0.33

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