INT52305

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Context Info
Confidence 0.15
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.95
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
nucleus 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 99.96 Very High Very High Very High
Inflammation 126 98.96 Very High Very High Very High
electroacupuncture 91 96.48 Very High Very High Very High
cytokine 46 92.68 High High
ischemia 3 92.00 High High
Dorsal column 2 84.76 Quite High
Inflammatory mediators 8 83.44 Quite High
Hyperalgesia 16 78.36 Quite High
Inflammatory response 15 76.96 Quite High
dexamethasone 4 76.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 139 98.96 Very High Very High Very High
Pressure And Volume Under Development 23 98.60 Very High Very High Very High
Spinal Cord Injury 39 97.80 Very High Very High Very High
Necrosis 3 95.52 Very High Very High Very High
Cancer 2 95.16 Very High Very High Very High
Brain Hemorrhage 2 92.00 High High
Congenital Anomalies 3 89.92 High High
Adhesions 2 88.16 High High
Injury 50 87.48 High High
Contusions 17 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A DNA binding domain of the glucocorticoid receptor interacted with a rat GRE (RGRE) with an apparent affinity intermediate between that of a consensus positive GRE oligo (GRE+) and a mismatch GRE oligo (GRE-).
glucocorticoid receptor Binding (interacted) of
1) Confidence 0.15 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7755638 Disease Relevance 0 Pain Relevance 0.07
In radioligand binding assays, des-CIC and fluticasone exhibited similar high-affinity binding to the glucocorticoid receptor, whereas ciclesonide exhibited 100-fold less binding affinity than fluticasone [19].
glucocorticoid receptor Binding (binding) of
2) Confidence 0.15 Published 2010 Journal Nanoscale Res Lett Section Body Doc Link PMC2893943 Disease Relevance 0.14 Pain Relevance 0.16
Considering that des-CIC and fluticasone exhibited similar high-affinity binding to the glucocorticoid receptor [19], this differentiation of side effects is very significant.
glucocorticoid receptor Binding (binding) of
3) Confidence 0.11 Published 2010 Journal Nanoscale Res Lett Section Body Doc Link PMC2893943 Disease Relevance 0 Pain Relevance 0
This is further evidenced by our experiments with ADX rats and the glucocorticoid receptor antagonist, RU486.
glucocorticoid receptor Binding (experiments) of associated with antagonist
4) Confidence 0.11 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.91 Pain Relevance 1.03
One mechanism that explains the action of MP, is the binding of the glucocorticoid receptor, which mediates its anti-inflammatory properties.
glucocorticoid receptor Binding (binding) of associated with inflammation
5) Confidence 0.10 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808560 Disease Relevance 0.82 Pain Relevance 0.20
It also binds to glucocorticoid receptor with specific affinity and triggers transcriptional activation of glucocorticoid response elements-containing receptor plasmids (21).
glucocorticoid receptor Binding (binds) of
6) Confidence 0.09 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808608 Disease Relevance 0.86 Pain Relevance 0.05
Glucocorticoids act through a cytosolic glucocorticoid receptor that eventually translocates into the nucleus and binds to specific DNA sequences called glucocorticoid response elements to regulate gene transcription (Aranda and Pascual, 2001).
cytosolic glucocorticoid receptor Binding (binds) of in nucleus
7) Confidence 0.01 Published 2008 Journal Clinical Medicine. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2990232 Disease Relevance 1.22 Pain Relevance 0.40

General Comments

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