INT52326

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.94
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)
Anatomy Link Frequency
nucleus accumbens 1
hypothalamus 1
cerebral cortex 1
thalamus 1
Atf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Dynorphin 3 99.84 Very High Very High Very High
Morphine 12 99.52 Very High Very High Very High
Nucleus accumbens 6 99.16 Very High Very High Very High
antidepressant 4 97.96 Very High Very High Very High
amygdala 3 97.40 Very High Very High Very High
Thalamus 3 96.68 Very High Very High Very High
cerebral cortex 3 96.28 Very High Very High Very High
addiction 3 89.88 High High
opiate 3 89.48 High High
Disease Link Frequency Relevance Heat
Shock 5 99.72 Very High Very High Very High
Breast Cancer 8 90.96 High High
Opiate Addiction 3 89.88 High High
Targeted Disruption 33 85.40 High High
Depression 2 74.72 Quite High
Obesity 5 54.72 Quite High
Apoptosis 26 14.04 Low Low
Wound Healing 15 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.
Negative_regulation (Inhibition) of cAMP response element-binding protein in nucleus accumbens associated with nucleus accumbens, antidepressant, dynorphin and enkephalin
1) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Title Doc Link 12486182 Disease Relevance 0.28 Pain Relevance 0.65
Using this method, we found that cAMP response element (CRE) binding activity was decreased by chronic morphine treatment in specific regions including the amygdala complex, thalamus, cerebral cortex and hypothalamus in mouse brain.
Negative_regulation (decreased) of cAMP response element in thalamus associated with thalamus, cerebral cortex, amygdala and morphine
2) Confidence 0.33 Published 1995 Journal Neuroreport Section Abstract Doc Link 7756606 Disease Relevance 0.09 Pain Relevance 0.62
Using this method, we found that cAMP response element (CRE) binding activity was decreased by chronic morphine treatment in specific regions including the amygdala complex, thalamus, cerebral cortex and hypothalamus in mouse brain.
Negative_regulation (decreased) of cAMP response element in hypothalamus associated with thalamus, cerebral cortex, amygdala and morphine
3) Confidence 0.11 Published 1995 Journal Neuroreport Section Abstract Doc Link 7756606 Disease Relevance 0.09 Pain Relevance 0.62
Using this method, we found that cAMP response element (CRE) binding activity was decreased by chronic morphine treatment in specific regions including the amygdala complex, thalamus, cerebral cortex and hypothalamus in mouse brain.
Negative_regulation (decreased) of cAMP response element in cerebral cortex associated with thalamus, cerebral cortex, amygdala and morphine
4) Confidence 0.11 Published 1995 Journal Neuroreport Section Abstract Doc Link 7756606 Disease Relevance 0.09 Pain Relevance 0.62
In the short time following its discovery, NCoA6 has emerged as an important coactivator not only for NRs, but also for a number of other well known transcription factors such as c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, Rb, p53 and Stat2 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].
Negative_regulation (number) of ATF-2 associated with shock
5) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.39 Pain Relevance 0
The loss of a conserved CRE element from the Per2 promoter may be a component of its functional divergence from Per1.
Negative_regulation (loss) of CRE element
6) Confidence 0.00 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0
The only gene lacking a conserved CRE element within 2 kb of the start codon was Nr4a1.
Negative_regulation (lacking) of CRE element
7) Confidence 0.00 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0

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