INT52335

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Context Info
Confidence 0.02
First Reported 1995
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.43
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
Dloc1 (Mus musculus)
Pain Link Frequency Relevance Heat
action potential duration 3 100.00 Very High Very High Very High
Morphine 3 99.60 Very High Very High Very High
primary somatosensory cortex 136 98.72 Very High Very High Very High
antagonist 2 98.52 Very High Very High Very High
MU agonist 2 97.40 Very High Very High Very High
dorsal root ganglion 4 92.84 High High
opioid receptor 4 90.72 High High
Immobilon 1 86.36 High High
Opioid 2 85.52 High High
Neurotransmitter 2 81.60 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 97.30 Very High Very High Very High
Ganglion Cysts 4 92.84 High High
Pressure And Volume Under Development 4 78.52 Quite High
Nicotine Addiction 15 5.00 Very Low Very Low Very Low
Obesity 14 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of naive nociceptive types of neurons with pM concentrations of these antagonists blocks excitatory prolongation of the calcium-dependent component of the action potential duration (APD) elicited by pM-nM morphine or other bimodally acting mu, delta and kappa opioid agonists and unmasks inhibitory APD shortening which usually requires much higher (ca. microM) concentrations.
Positive_regulation (elicited) of action potential duration in neurons associated with nociception, mu agonist, action potential duration, antagonist and morphine
1) Confidence 0.02 Published 1995 Journal Brain Res. Section Abstract Doc Link 7757476 Disease Relevance 0.35 Pain Relevance 1.08
Alternatively, the observed OIS periodicities might reflect the spatial organization of the cortical glial reaction to local neuroelectrical activity, or SI microvascular responses [32], which become more prominent with increases in both stimulus strength and duration.
Positive_regulation (increases) of duration associated with primary somatosensory cortex
2) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1183216 Disease Relevance 0.08 Pain Relevance 0.27
In other words, with increasing stimulus duration, the local aggregates of above background absorbance tend to form larger clusters – which would lead to higher periodic values (lower spatial frequencies).
Positive_regulation (increasing) of duration
3) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1183216 Disease Relevance 0 Pain Relevance 0.07
Neither intervention increased breastfeeding initiation or duration compared to standard care.
Neg (Neither) Positive_regulation (increased) of duration
4) Confidence 0.01 Published 2006 Journal Int Breastfeed J Section Body Doc Link PMC1635041 Disease Relevance 0 Pain Relevance 0

General Comments

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