INT5235

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2011
Negated 10
Speculated 17
Reported most in Abstract
Documents 924
Total Number 941
Disease Relevance 772.91
Pain Relevance 331.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
monocytes 12
joint 11
T-cell 10
plasma 7
spinal 6
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11468 100.00 Very High Very High Very High
cytokine 6867 100.00 Very High Very High Very High
spinal inflammation 3101 100.00 Very High Very High Very High
antagonist 1180 100.00 Very High Very High Very High
Inflammatory response 896 100.00 Very High Very High Very High
chemokine 858 100.00 Very High Very High Very High
Spinal cord 649 100.00 Very High Very High Very High
metalloproteinase 603 100.00 Very High Very High Very High
Inflammatory mediators 475 100.00 Very High Very High Very High
Inflammatory stimuli 79 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 12834 100.00 Very High Very High Very High
Cancer 5046 100.00 Very High Very High Very High
Apoptosis 3286 100.00 Very High Very High Very High
Necrosis 2272 100.00 Very High Very High Very High
Low Back Pain 1754 100.00 Very High Very High Very High
Targeted Disruption 896 100.00 Very High Very High Very High
Uveitis 836 100.00 Very High Very High Very High
Pneumonia 444 100.00 Very High Very High Very High
Nicotine Addiction 324 100.00 Very High Very High Very High
Hypertension 301 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNFalpha inhibition has been used successfully as part of an induction therapy for pancreatic islet cell transplantation.
Negative_regulation (inhibition) of TNFalpha in pancreatic islet
1) Confidence 0.59 Published 2005 Journal BioDrugs Section Abstract Doc Link 16128605 Disease Relevance 0.90 Pain Relevance 0.09
Biologics in the treatment of transplant rejection and ischemia/reperfusion injury: new applications for TNFalpha inhibitors?
Negative_regulation (inhibitors) of TNFalpha associated with reperfusion injury, ischemia and organ transplantation
2) Confidence 0.59 Published 2005 Journal BioDrugs Section Title Doc Link 16128605 Disease Relevance 1.45 Pain Relevance 0.47
Morphine may improve condition of cancer patients by suppression of tumour growth and reduction of amounts of an endogenous tumor promoter, TNF-alpha, in tissues.
Negative_regulation (reduction) of TNF-alpha associated with cancer and morphine
3) Confidence 0.59 Published 1996 Journal Carcinogenesis Section Abstract Doc Link 8968046 Disease Relevance 1.10 Pain Relevance 0.79
Data are presented from animal studies and human clinical trials designed to test the efficacy of TNF inhibition in AS.
Negative_regulation (inhibition) of TNF
4) Confidence 0.59 Published 2005 Journal Semin. Arthritis Rheum. Section Body Doc Link 15692960 Disease Relevance 0.25 Pain Relevance 0
Understanding the role of tumor necrosis factor inhibition in ankylosing spondylitis.
Negative_regulation (inhibition) of tumor necrosis factor associated with spinal inflammation, necrosis and cancer
5) Confidence 0.59 Published 2005 Journal Semin. Arthritis Rheum. Section Title Doc Link 15692960 Disease Relevance 0.77 Pain Relevance 0.57
A number of clinical trials for the treatment of rheumatoid arthritis with infliximab indicated that TNF alpha blockade was effective and well tolerated, with excellent results occurring at 3 and 10 mg/kg in combination with methotrexate.
Negative_regulation (blockade) of TNF alpha associated with infliximab, rheumatoid arthritis and methotrexate
6) Confidence 0.59 Published 2004 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 15077061 Disease Relevance 1.04 Pain Relevance 0.87
Inhibition of TNF-alpha has been shown to provide benefit in such inflammatory conditions as rheumatoid arthritis, psoriatic arthritis, and, most recently, plaque psoriasis.
Negative_regulation (Inhibition) of TNF-alpha in plaque associated with seronegative spondarthritis, psoriasis, inflammation, rheumatoid arthritis and arthritis
7) Confidence 0.59 Published 2005 Journal J Drugs Dermatol Section Abstract Doc Link 15898294 Disease Relevance 1.12 Pain Relevance 0.59
In this report, we present the case of a 65-year-old man with a 9-year history of recalcitrant ACH who demonstrated significant and sustained clinical improvement when etanercept, a competitive inhibitor of TNF-alpha, was added to his treatment regimen of acitretin and topical corticosteroids over a 12-week period.
Negative_regulation (inhibitor) of TNF-alpha associated with corticosteroid and etanercept
8) Confidence 0.59 Published 2005 Journal J Drugs Dermatol Section Abstract Doc Link 15898294 Disease Relevance 0.99 Pain Relevance 0.56
This supposition was supported by measurements on totally stripped human tissues, since removal of subepithelial layers by total stripping reduced the TNF-alpha effect by 40%.
Negative_regulation (reduced) of TNF-alpha
9) Confidence 0.59 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8897887 Disease Relevance 0.69 Pain Relevance 0.13
In particular, antibodies that bind to and neutralise TNF have been sought as a means to inhibit TNF activity.
Negative_regulation (inhibit) of TNF
10) Confidence 0.59 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19689289 Disease Relevance 1.47 Pain Relevance 0.65
Inhibition of TNF has proven to be an effective therapy for patients with rheumatoid arthritis and other forms of inflammatory disease including psoriasis, psoriatic arthritis, and ankylosing spondylitis, inflammatory bowel disease.
Negative_regulation (Inhibition) of TNF in bowel associated with seronegative spondarthritis, spinal inflammation, psoriasis, inflammation, rheumatoid arthritis, disease and arthritis
11) Confidence 0.59 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19689289 Disease Relevance 1.53 Pain Relevance 0.67
Certolizumab pegol is a novel TNF inhibitor which is an antigen-binding domain of a humanized TNF antibody coupled to polyethylene glycol (PEG) to increase half-life, and thus is Fc-domain-free.
Negative_regulation (inhibitor) of TNF
12) Confidence 0.59 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19689289 Disease Relevance 1.38 Pain Relevance 0.67
Inhibitors of tumor necrosis factor-alpha have deeply changed the therapy of several inflammatory human diseases.
Negative_regulation (Inhibitors) of tumor necrosis factor-alpha associated with necrosis, inflammation, cancer and disease
13) Confidence 0.59 Published 2009 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 19822073 Disease Relevance 0.81 Pain Relevance 0.44
The potency of this novel drug in blocking TNF activity has been shown in animal models and in clinical trials.
Negative_regulation (blocking) of TNF associated with potency
14) Confidence 0.58 Published 2004 Journal Drugs Today Section Abstract Doc Link 15190385 Disease Relevance 1.18 Pain Relevance 0.79
TNF inhibitors should be stopped in the presence of serious infections.
Negative_regulation (inhibitors) of TNF associated with infection
15) Confidence 0.58 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643111 Disease Relevance 1.51 Pain Relevance 0.54
Listeria infections have been reported in 26 patients receiving TNF-alpha inhibitors.
Negative_regulation (inhibitors) of TNF-alpha associated with listeria infections
16) Confidence 0.58 Published 2006 Journal Z Gastroenterol Section Abstract Doc Link 16902896 Disease Relevance 0.92 Pain Relevance 0.24
CONCLUSIONS: Treatment of active AS with TNF blockade appears to be associated with improved capacity for work.


Negative_regulation (blockade) of TNF
17) Confidence 0.58 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18281690 Disease Relevance 0 Pain Relevance 0
Biologic therapies now approved for use in inflammatory joint diseases are TNF inhibitors, T-cell modulators and B-cell depleters.
Negative_regulation (inhibitors) of TNF in B-cell associated with inflammation and arthropathy
18) Confidence 0.58 Published 2009 Journal Expert Rev Clin Immunol Section Abstract Doc Link 20477007 Disease Relevance 0.98 Pain Relevance 0.43
Systemic administration of iloprost inhibited serum TNF levels after intraperitoneal LPS, whereas intracerebroventricular injection of iloprost or PGE2 did not inhibit brain TNF induced by intracerebroventricular LPS.
Negative_regulation (inhibited) of TNF in brain associated with intracerebroventricular
19) Confidence 0.58 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.70 Pain Relevance 0.71
In fact, indomethacin decreased (1.4-1.8-fold) TNF levels in the spinal cord of rats with experimental autoimmune encephalomyelitis and in the cortex of rats with focal cerebral ischemia.
Negative_regulation (decreased) of TNF in cortex associated with brain hemorrhage, multiple sclerosis, ischemia and spinal cord
20) Confidence 0.58 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.73 Pain Relevance 0.72

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