INT52350

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 13
Speculated 6
Reported most in Body
Documents 184
Total Number 190
Disease Relevance 71.37
Pain Relevance 33.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
monocytes 64
macrophages 10
T cells 9
dendritic cells 5
neutrophils 5
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2161 100.00 Very High Very High Very High
rheumatoid arthritis 1876 100.00 Very High Very High Very High
chemokine 581 100.00 Very High Very High Very High
agonist 244 100.00 Very High Very High Very High
local anesthetic 61 99.74 Very High Very High Very High
Potency 7 99.72 Very High Very High Very High
orphanin 14 99.64 Very High Very High Very High
anesthesia 641 99.60 Very High Very High Very High
Morphine 62 99.44 Very High Very High Very High
spinal inflammation 330 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2484 100.00 Very High Very High Very High
Rheumatoid Arthritis 2111 100.00 Very High Very High Very High
Cirrhosis 185 99.98 Very High Very High Very High
Dengue Hemorrhagic Fever 67 99.68 Very High Very High Very High
Disease 1039 99.64 Very High Very High Very High
Pulmonary Disease 568 99.52 Very High Very High Very High
Low Back Pain 326 99.36 Very High Very High Very High
Leukemia 50 99.14 Very High Very High Very High
Pulpitis 6 99.12 Very High Very High Very High
Obesity 424 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This negative selection method resulted in a cell population containing more than 90% monocytes as determined by CD14 expression.


Spec (determined) Gene_expression (expression) of CD14 in monocytes
1) Confidence 0.75 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333421 Disease Relevance 0 Pain Relevance 0
In addition, baseline sCD14 plasma levels, and interleukin-6 production by circulating monocytes after in-vitro stimulation with lipopolysaccharide (1 ng/ml) were assessed.
Gene_expression (production) of CD14 in monocytes
2) Confidence 0.75 Published 2010 Journal J Cardiovasc Med (Hagerstown) Section Body Doc Link 19829130 Disease Relevance 0.09 Pain Relevance 0
CD14 expression on neutrophils was measured after incubation with fluorescein isothiocyanate-labelled antibodies.
Gene_expression (expression) of CD14 in neutrophils
3) Confidence 0.74 Published 2007 Journal Eur J Anaesthesiol Section Body Doc Link 17583593 Disease Relevance 0 Pain Relevance 0
Morphine inhibits AP-1 activity and CD14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism.
Gene_expression (expression) of CD14 in leukocytes associated with opioid receptor and morphine
4) Confidence 0.74 Published 2007 Journal Eur J Anaesthesiol Section Title Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.24
CD14 expression on neutrophils was reduced after morphine treatment.
Gene_expression (expression) of CD14 in neutrophils
5) Confidence 0.74 Published 2007 Journal Eur J Anaesthesiol Section Body Doc Link 17583593 Disease Relevance 0 Pain Relevance 0
Activation of phagocytes by lipopolysaccharide depends on the expression of CD14 on the cell surface.
Gene_expression (expression) of CD14 in phagocytes
6) Confidence 0.74 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
In this study, we investigated the effects of morphine and nitric oxide on CD14 expression and activator protein 1 activation in human blood monocytes and neutrophils as well as the leukocyte cell line HL-60.
Gene_expression (expression) of CD14 in monocytes associated with morphine
7) Confidence 0.74 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
The decrease in CD14 expression caused by morphine may play a role in inhibition of activator protein 1 activation following lipopolysaccharide treatment of phagocytes.


Gene_expression (expression) of CD14 in phagocytes
8) Confidence 0.74 Published 2007 Journal Eur J Anaesthesiol Section Body Doc Link 17583593 Disease Relevance 0 Pain Relevance 0
Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.
Gene_expression (production) of CD14 in monocytes associated with chemokine and orphanin
9) Confidence 0.65 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.87
The PBMCs were labeled with CD3, CD14, CD19 and CD56 microbeads for depletion of T cells, B cells, NK cells and monocytes according to manufactures description (Miltenyi Biotec, Germany).
Gene_expression (microbeads) of CD14 in NK cells
10) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.20 Pain Relevance 0
The amount of TLR2, TLR4 and CD14 on the monocyte cell surface was measured by FACS.
Gene_expression (amount) of CD14 in monocyte
11) Confidence 0.65 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0 Pain Relevance 0
The concentrations of lymphocytes expressing the cluster designation (CD) cell-surface antigens CD3, CD4, CD8, and CD14 became elevated during exercise, and these responses were enhanced by hypoxia (P < or = 0.01).
Gene_expression (expressing) of CD14 in lymphocytes associated with hypoxia
12) Confidence 0.63 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7759444 Disease Relevance 0.41 Pain Relevance 0.24
PBMCs were isolated, and TLR4 and CD14 expression on PBMCs was detected by flow cytometer.
Gene_expression (expression) of CD14
13) Confidence 0.60 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.71 Pain Relevance 0.09
However, there were no CD14 expression in human dental pulp cells before and after LPS stimulation.
Neg (no) Gene_expression (expression) of CD14 in dental pulp
14) Confidence 0.60 Published 2006 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 16836908 Disease Relevance 0.08 Pain Relevance 0
[Expression of lipopolysaccharides signal receptors CD14 and TLR4 in human dental pulp tissue and fibroblasts].
Gene_expression (Expression) of CD14 in dental pulp
15) Confidence 0.60 Published 2006 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Title Doc Link 16836908 Disease Relevance 0 Pain Relevance 0.09
OBJECTIVE: To investigate the expression of lipopolysaccharides (LPS) receptors CD14 and TLR4 in normal and inflamed human dental pulp tissue and fibroblasts and to determine the signal transduction pathway of LPS in pulpitis.
Spec (investigate) Gene_expression (expression) of CD14 in dental pulp associated with pulpitis
16) Confidence 0.60 Published 2006 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Abstract Doc Link 16836908 Disease Relevance 0.10 Pain Relevance 0.10
METHODS: CD14 and TLR4 expression in healthy and inflammatory pulps was observed by immunohistochemistry.
Gene_expression (expression) of CD14
17) Confidence 0.60 Published 2006 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 16836908 Disease Relevance 0.10 Pain Relevance 0
RESULTS: CD14 and TLR4 were not detected in healthy pulp tissues, but they were strongly positively stained in inflammatory pulps.
Neg (not) Gene_expression (detected) of CD14
18) Confidence 0.60 Published 2006 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 16836908 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: This study revealed a significant increase in the expression of CD14 and TLR4 in inflamed human dental pulp tissue.
Gene_expression (expression) of CD14 in dental pulp
19) Confidence 0.60 Published 2006 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 16836908 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical staining reveals that macrophages in tenosynovial tissues express CD13, CD14, CD33, HLA-DR, and CD68 antigens on their surfaces and express interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and IL-6.
Gene_expression (express) of CD14 in macrophages associated with necrosis and cancer
20) Confidence 0.59 Published 2001 Journal Semin Dial Section Abstract Doc Link 11264784 Disease Relevance 0.83 Pain Relevance 0.12

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