INT52357

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Context Info
Confidence 0.16
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.49
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sub1) nucleus (Sub1) DNA binding (Sub1)
Anatomy Link Frequency
macrophages 2
spinal 1
endothelial cells 1
IB4 1
Sub1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 4 99.96 Very High Very High Very High
Inflammation 25 98.76 Very High Very High Very High
nMDA receptor 3 96.24 Very High Very High Very High
Neuritis 7 94.00 High High
Demyelination 6 91.36 High High
Dorsal horn 2 86.20 High High
Spinal cord 1 84.16 Quite High
dorsal root ganglion 2 83.64 Quite High
Glutamate 2 82.96 Quite High
Neurotransmitter 2 81.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 25 98.76 Very High Very High Very High
Stress 7 95.08 Very High Very High Very High
Experimental Autoimmune Neuritis 7 94.00 High High
Demyelinating Disease 6 91.36 High High
Ganglion Cysts 2 83.64 Quite High
Pain 18 76.88 Quite High
Disease 1 73.28 Quite High
Nociception 10 67.60 Quite High
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on our previous observations of preferential targeting of VR1-positive primary afferents to spinal neurons that express the neurokinin receptor NK1 (Hwang et al., 2003), we further quantified the frequency of termination of VR1-positive afferents onto NK1-positive neurons co-expressing glutamate receptors.
Gene_expression (expressing) of NK1-positive in spinal associated with glutamate receptor
1) Confidence 0.16 Published 2004 Journal J. Neurocytol. Section Abstract Doc Link 15475687 Disease Relevance 0.15 Pain Relevance 0.57
Endoneurial infiltrates had fewer ED1-positive (phagocytic) macrophages (0.4 +/- 0.5 vs. 1.6 +/- 1.1) and CD11bc-positive (expressing iC3b receptor or CR3) cells (1 +/- 0.8 vs. 2.5 +/- 0.8) (mean +/- S.D.) detected by immunocytochemistry.
Gene_expression (expressing) of CD11bc-positive in macrophages
2) Confidence 0.13 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7759605 Disease Relevance 0.75 Pain Relevance 0.59
Immunocytochemistry of lumbosacral nerve roots showed significantly less ED1-positive macrophages (0.5 +/- 0.3 vs 1.6 +/- 0.6, P < 0.04) and CD11bc-positive (expressing complement receptor 3 or CR3) inflammatory cells (0.6 +/- 0.4 vs 1.7 +/- 0.5, P < 0.03).
Gene_expression (expressing) of CD11bc-positive in macrophages associated with inflammation
3) Confidence 0.10 Published 1998 Journal Acta Neuropathol. Section Abstract Doc Link 9542596 Disease Relevance 0.76 Pain Relevance 0.49
All immediate early gene-encoded protein expressions except c-Jun were evoked, but except for c-Fos, and to a lesser extent Jun D, intensities of staining always remained faint.
Gene_expression (expressions) of gene-encoded protein
4) Confidence 0.07 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152540 Disease Relevance 0.37 Pain Relevance 0.33
Cultured porcine endothelial cells showed a dose-dependent expression of Trpv4 and an increased level of Ki67-positive cells upon treatment with 4alpha-Phorbol 12,13-didecanoate (4alphaPDD), a specific Trpv4 activator.
Gene_expression (expression) of Ki67-positive in endothelial cells
5) Confidence 0.01 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.47 Pain Relevance 0.08
In both IB4-positive and IB4-negative cells, only the GRO/KC without CHX group differed significantly, from all three other groups.


Neg (negative) Gene_expression (negative) of IB4-positive in IB4
6) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.20

General Comments

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