INT52358

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 18.48
Pain Relevance 16.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)
Anatomy Link Frequency
spinal cord 6
microglia 5
macrophages 3
nerve 2
intrinsic neurons 1
Cx3cr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 30 100.00 Very High Very High Very High
Inflammation 48 99.92 Very High Very High Very High
Spinal cord 92 99.84 Very High Very High Very High
Hyperalgesia 10 99.36 Very High Very High Very High
Neuropathic pain 47 99.30 Very High Very High Very High
Eae 49 99.24 Very High Very High Very High
Neuritis 16 99.16 Very High Very High Very High
Dorsal horn 7 99.00 Very High Very High Very High
Pain 62 98.96 Very High Very High Very High
Peripheral nerve injury 22 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 131 99.92 Very High Very High Very High
INFLAMMATION 49 99.92 Very High Very High Very High
Hyperalgesia 32 99.36 Very High Very High Very High
Injury 50 99.24 Very High Very High Very High
Experimental Autoimmune Neuritis 16 99.16 Very High Very High Very High
Nociception 14 99.04 Very High Very High Very High
Pain 49 98.96 Very High Very High Very High
Ganglion Cysts 11 98.96 Very High Very High Very High
Nervous System Injury 34 98.52 Very High Very High Very High
Inflammatory Pain 4 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis revealed that CX3CR1 expression in the spinal cord was significantly increased following CFA-induced MA.
Gene_expression (expression) of CX3CR1 in spinal cord associated with spinal cord
1) Confidence 0.78 Published 2007 Journal Pain Section Abstract Doc Link 17123734 Disease Relevance 0.59 Pain Relevance 0.87
CX3CR1-expressing cells were identified as microglia by their cellular morphology and positive OX-42 and CD4 immunostaining.
Gene_expression (expressing) of CX3CR1 in microglia
2) Confidence 0.78 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 0.89 Pain Relevance 0.78
Its only receptor, CX3CR1, is expressed by microglia.
Gene_expression (expressed) of CX3CR1 in microglia
3) Confidence 0.78 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 0.43 Pain Relevance 0.57
By contrast, CX3CR1 was expressed by microglia in the basal state, and the microglial cellular concentration was up-regulated in a regionally specific manner in response to neuropathy.
Gene_expression (expressed) of CX3CR1 in microglia associated with neuropathic pain
4) Confidence 0.78 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 0.96 Pain Relevance 0.85
Spinal fractalkine (CX3CL1) is expressed by sensory afferents and intrinsic neurons, whereas its receptor (CX3CR1) is predominantly expressed by microglia.
Gene_expression (expressed) of CX3CR1 in intrinsic neurons
5) Confidence 0.73 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324111 Disease Relevance 0.47 Pain Relevance 0.57
Little is known about the expression of fractalkine and CX3CR1 in spinal cord.
Gene_expression (expression) of CX3CR1 in spinal cord associated with spinal cord
6) Confidence 0.68 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15341587 Disease Relevance 0.51 Pain Relevance 0.63
The expression of the chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 were also higher in EAN than in control dorsal horns suggesting spinal microglia and CX3CL1/CX3CR1 may play a role in the pain-like behaviour.
Gene_expression (expression) of CX3CR1 in microglia associated with pain, chemokine and neuritis
7) Confidence 0.67 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18448252 Disease Relevance 1.05 Pain Relevance 0.89
The purpose of this study was to provide an immunohistochemical description of the distribution of CX3CL1 (fractalkine) and its receptor CX3CR1 in the rat spinal cord in a model of inflammatory pain induced by unilateral intraplantar complete Freund's adjuvant (CFA) and in a model of neuropathic pain induced by L5 spinal nerve ligation (modified Chung model or mSNL).
Gene_expression (distribution) of CX3CR1 in spinal cord associated with spinal nerve ligature, ipn, chung model, neuropathic pain and spinal cord
8) Confidence 0.66 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.36 Pain Relevance 0.66
The increases in CX3CR1 expression, p38 MAPK activation and pain behavior after CCI were suppressed by blocking IL-6 action with a neutralizing antibody, while they were enhanced by supplying exogenous recombinant rat IL-6 (rrIL-6). rrIL-6 also induced increases in spinal CX3CR1 expression, p38 MAPK activation and pain behavior in nai ve rats without nerve injury.
Gene_expression (expression) of CX3CR1 in nerve associated with pain, nervous system injury and eae
9) Confidence 0.57 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 1.12 Pain Relevance 0.88
Here, we investigated whether IL-6 regulates CX3CR1 expression through p38 MAPK activation in the spinal cord in rats with chronic constriction injury (CCI) of the sciatic nerve.
Gene_expression (expression) of CX3CR1 in sciatic nerve associated with eae, injury, sciatic nerve and spinal cord
10) Confidence 0.57 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 0.79 Pain Relevance 0.67
Similar temporal changes in the expression of IL-6, phosphorylated p38 MAPK and CX3CR1 were observed following CCI.
Gene_expression (expression) of CX3CR1 associated with eae
11) Confidence 0.57 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 0.92 Pain Relevance 0.73
Peripheral nerve injury leading to neuropathic pain induces the upregulation of interleukin (IL)-6 and microglial CX3CR1 expression, and activation of p38 mitogen-activated protein kinase (MAPK) in the spinal cord.
Gene_expression (expression) of CX3CR1 in spinal cord associated with nervous system injury, neuropathic pain, spinal cord and peripheral nerve injury
12) Confidence 0.57 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 0.63 Pain Relevance 0.57
The increases in CX3CR1 expression, p38 MAPK activation and pain behavior after CCI were suppressed by blocking IL-6 action with a neutralizing antibody, while they were enhanced by supplying exogenous recombinant rat IL-6 (rrIL-6). rrIL-6 also induced increases in spinal CX3CR1 expression, p38 MAPK activation and pain behavior in nai ve rats without nerve injury.
Gene_expression (expression) of CX3CR1 in nerve associated with pain, nervous system injury and eae
13) Confidence 0.57 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 1.23 Pain Relevance 1.02
Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK.
Gene_expression (expression) of CX3CR1 in spinal cord associated with nervous system injury, peripheral nerve injury and spinal cord
14) Confidence 0.57 Published 2010 Journal Eur J Pain Section Title Doc Link 19959384 Disease Relevance 1.01 Pain Relevance 0.82
These results suggest a new mechanism of neuropathic pain, in which IL-6 induces microglial CX3CR1 expression in the spinal cord through p38 MAPK activation, enhancing the responsiveness of microglia to fractalkine in the spinal cord, thus playing an important role in neuropathic pain after peripheral nerve injury.
Gene_expression (expression) of CX3CR1 in spinal cord associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
15) Confidence 0.57 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 1.29 Pain Relevance 1.12
AREAS COVERED IN THIS REVIEW: We performed a Medline/PubMed search to detect all published studies that explored the role of fractalkine and CX3CR1 and the possibilities of therapeutic intervention in the fractalkine/CX3CR1 axis in a wide range of clinical disorders, using CX3CR1 blocking antibodies, different fractalkine antagonists, CX3CR1 depletion or transfection of fractalkine expression vectors.
Gene_expression (axis) of CX3CR1
16) Confidence 0.56 Published 2010 Journal Expert Opin. Ther. Targets Section Body Doc Link 20055718 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: Increases in the FKN level and the number of CX3CR1-expressing mononuclear cells might contribute to coronary plaque rupture.


Gene_expression (mononuclear cells) of CX3CR1-expressing in mononuclear cells
17) Confidence 0.50 Published 2010 Journal Circ. J. Section Body Doc Link 20019415 Disease Relevance 0.06 Pain Relevance 0
AREAS COVERED IN THIS REVIEW: We performed a Medline/PubMed search to detect all published studies that explored the role of fractalkine and CX3CR1 and the possibilities of therapeutic intervention in the fractalkine/CX3CR1 axis in a wide range of clinical disorders, using CX3CR1 blocking antibodies, different fractalkine antagonists, CX3CR1 depletion or transfection of fractalkine expression vectors.
Gene_expression (role) of CX3CR1
18) Confidence 0.49 Published 2010 Journal Expert Opin. Ther. Targets Section Body Doc Link 20055718 Disease Relevance 0.09 Pain Relevance 0
However, to date, no therapeutics targeting fractalkine or CX3CR1 are in clinical use.


Gene_expression (targeting) of CX3CR1
19) Confidence 0.49 Published 2010 Journal Expert Opin. Ther. Targets Section Body Doc Link 20055718 Disease Relevance 0.06 Pain Relevance 0
BACKGROUND: Recent studies suggest that fractalkine (FKN or CX3CL1) and its cognate receptor, CX3CR1, play a role in atherogenesis, so the relationship between coronary plaque rupture, as observed by preintervention optical coherence tomography, and plasma levels of FKN and CX3CR1 was investigated in this study.
Gene_expression (levels) of CX3CR1 in plaque associated with rupture and atherosclerosis
20) Confidence 0.45 Published 2010 Journal Circ. J. Section Abstract Doc Link 20019415 Disease Relevance 0.42 Pain Relevance 0.15

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