INT52392

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Context Info
Confidence 0.64
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.23
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
NG108-15 4
ovary 4
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 34 100.00 Very High Very High Very High
Enkephalin 6 99.90 Very High Very High Very High
narcan 9 99.68 Very High Very High Very High
MU agonist 2 99.20 Very High Very High Very High
agonist 7 96.52 Very High Very High Very High
mu opioid receptor 1 95.72 Very High Very High Very High
Opioid 8 94.28 High High
Kappa opioid receptor 1 92.48 High High
Delta opioid receptors 3 88.20 High High
antagonist 3 87.68 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 99.84 Very High Very High Very High
Bordatella Infection 4 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Eu-diethylenetriaminepentaacetic acid (DTPA)-[D-Pen(2),l-Cys(5)] enkephalin (DPLCE) ligand bound to Chinese hamster ovary (CHO) cells overexpressing the human delta-opioid receptor with affinity similar to the unlabeled ligand.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of delta-opioid receptor in ovary associated with opioid receptor and enkephalin
1) Confidence 0.64 Published 2005 Journal Anal. Biochem. Section Abstract Doc Link 16004955 Disease Relevance 0 Pain Relevance 0.23
In NG108-15 cells, NDMC inhibited cyclic AMP formation and stimulated the phosphorylation of extracellular signal-regulated kinase 1/2 by activating the endogenously expressed delta-opioid receptor.
Positive_regulation (activating) of Gene_expression (expressed) of delta-opioid receptor in NG108-15 associated with opioid receptor
2) Confidence 0.61 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16841075 Disease Relevance 0 Pain Relevance 0.66
The inhibitory response of [D-Pen2,D-Pen5]-enkephalin was dependent on the expression of the delta-opioid receptor and exhibited an EC50 of 1 nM.
Positive_regulation (dependent) of Gene_expression (expression) of delta-opioid associated with opioid receptor and enkephalin
3) Confidence 0.48 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7760050 Disease Relevance 0.08 Pain Relevance 0.81
Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.
Positive_regulation (transfected) of Gene_expression (transfected) of delta-opioid receptor in ovary associated with mu agonist and opioid receptor
4) Confidence 0.32 Published 2001 Journal Mol. Pharmacol. Section Title Doc Link 11641436 Disease Relevance 0.05 Pain Relevance 0.32
Ethanol and naloxone differentially upregulate delta opioid receptor gene expression in neuroblastoma hybrid (NG108-15) cells.
Positive_regulation (upregulate) of Gene_expression (expression) of delta opioid receptor gene in NG108-15 associated with neuroblastoma, narcan and opioid receptor
5) Confidence 0.02 Published 1994 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7877460 Disease Relevance 0.10 Pain Relevance 0.84
GH3MOR cells, further transfected with mouse delta receptor cDNA (termed GH3MORDOR cells), bound both [D-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO) and [D-Pen2,D-Pen5]enkephalin (DPDPE).
Positive_regulation (transfected) of Gene_expression (transfected) of delta receptor cDNA associated with enkephalin
6) Confidence 0.00 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863841 Disease Relevance 0 Pain Relevance 0.57

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