INT52402

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.46
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr2c) nucleus (Htr2c) cytoplasm (Htr2c)
signal transducer activity (Htr2c)
Anatomy Link Frequency
brain 2
frontal cortex 1
Htr2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
5HT 10 100.00 Very High Very High Very High
Desipramine 6 99.96 Very High Very High Very High
sSRI 36 99.80 Very High Very High Very High
Dopamine 11 99.80 Very High Very High Very High
Migraine 7 99.14 Very High Very High Very High
Serotonin 18 98.64 Very High Very High Very High
fluoxetine 78 97.56 Very High Very High Very High
depression 66 96.12 Very High Very High Very High
antidepressant 51 94.08 High High
Eae 4 92.20 High High
Disease Link Frequency Relevance Heat
Headache 18 99.14 Very High Very High Very High
Eating Disorder 4 97.16 Very High Very High Very High
Urological Neuroanatomy 1 96.76 Very High Very High Very High
Anxiety Disorder 23 96.48 Very High Very High Very High
Depression 63 96.12 Very High Very High Very High
Cluster Headache 1 81.04 Quite High
Weight Gain 12 80.08 Quite High
Sleep Disorders 11 65.60 Quite High
Parkinson's Disease 1 60.60 Quite High
Disease 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Is migraine prophylactic activity caused by 5-HT2B or 5-HT2C receptor blockade?
Negative_regulation (blockade) of 5-HT2C associated with migraine
1) Confidence 0.42 Published 1994 Journal Life Sci. Section Title Doc Link 8107508 Disease Relevance 0.36 Pain Relevance 0.36
However, olanzapine also binds inhibits 5-HT2C, 5-HT3, 5-HT8, as well as norepinephrine (NE) alpha1, muscarinic cholinergic, histamine1, and glutaminergic receptors.
Negative_regulation (inhibits) of 5-HT2C
2) Confidence 0.42 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661658 Disease Relevance 0.06 Pain Relevance 0.29
As chronic fluoxetine and paroxetine did not reduce brain mCPP levels (determined by HPLC 30 min after 4 mg/kg i.p.) the results suggest that chronic SSRI's, but not desipramine, reduce 5-HT2C/5-HT2B receptor responsivity.
Negative_regulation (reduce) of 5-HT2C in brain associated with desipramine, ssri and fluoxetine
3) Confidence 0.41 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7760981 Disease Relevance 0 Pain Relevance 0.71
In addition, some of the actions may also be mediated by activation of the 5-HT2A receptor and/or inhibition of the 5-HT2C receptor.
Negative_regulation (inhibition) of 5-HT2C
4) Confidence 0.41 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9512061 Disease Relevance 0 Pain Relevance 0.99
By inhibiting 5HT-2C receptors, however, it secondarily increases norepinephrine and dopamine in the frontal cortex of the brain.36 This effect might contribute to its antidepressant activity.
Negative_regulation (inhibiting) of 5HT-2C in frontal cortex associated with antidepressant, dopamine, 5ht and urological neuroanatomy
5) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.48 Pain Relevance 0.81
Delayed decreases in brain 5-hydroxytryptamine2A/2C receptor density and function in male rat progeny following prenatal fluoxetine.
Negative_regulation (decreases) of 2C receptor in brain associated with fluoxetine
6) Confidence 0.26 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8182530 Disease Relevance 0.08 Pain Relevance 0.49
In the present study the possibility that SSRI's act by desensitizing 5-HT2C/5-HT2B receptors was assessed using a putative in vivo model of 5-HT2C/5-HT2B receptor function, mCPP-induced hypolocomotion. mCPP (2, 4 and 6 mg/kg i.p. 20 min pretest) reduced locomotion and rears in rats treated acutely or chronically with saline.
Negative_regulation (desensitizing) of 5-HT2C associated with ssri
7) Confidence 0.18 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7760981 Disease Relevance 0.48 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox