INT52409

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.28
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FBN1) extracellular region (FBN1) proteinaceous extracellular matrix (FBN1)
Anatomy Link Frequency
joint 1
capsule 1
tail 1
T-cell 1
FBN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 44 99.92 Very High Very High Very High
Angina 8 97.04 Very High Very High Very High
fibrosis 78 94.24 High High
Arthritis 103 92.88 High High
depression 2 92.56 High High
Inflammation 209 92.24 High High
COX2 56 91.20 High High
metalloproteinase 43 87.44 High High
diclofenac 34 75.68 Quite High
ischemia 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Death 220 100.00 Very High Very High Very High
Stress 441 99.90 Very High Very High Very High
INFLAMMATION 244 99.74 Very High Very High Very High
Cirrhosis 190 99.44 Very High Very High Very High
Disease 99 99.36 Very High Very High Very High
Fibrosis 154 98.88 Very High Very High Very High
Injury 201 97.92 Very High Very High Very High
Cv General 3 Under Development 8 97.04 Very High Very High Very High
Juvenile Chronic Polyarthritis 90 92.88 High High
Depression 2 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rest, stress, and delta WMS, number and distribution of ischemic segments, and number of segments with an increase in regional WMS of > or = 2 were not significantly different in patients with or without angina.
Positive_regulation (increase) of WMS associated with stress and angina
1) Confidence 0.40 Published 1995 Journal Am. J. Cardiol. Section Abstract Doc Link 7762495 Disease Relevance 1.92 Pain Relevance 0.78
T-cell responses to aggrecan and fibrillin are related to disease subtype
Positive_regulation (responses) of fibrillin in T-cell associated with disease
2) Confidence 0.14 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.45 Pain Relevance 0.66
A threshold at the 0.9 severity for coordination, toe clearance, and nearly normal trunk stability and tail usage required 25% WMS.
Positive_regulation (required) of WMS in tail
3) Confidence 0.12 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15649480 Disease Relevance 0.65 Pain Relevance 0.14
on human joint capsule MFs may be mediated even by endogenous prostaglandin synthesis.
Positive_regulation (mediated) of MFs in capsule
4) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.16 Pain Relevance 0.22
-SMA-positive MFs is notably increased in the biopsies of contracted joint capsules after injury.
Positive_regulation (increased) of MFs in joint associated with injury
5) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.28 Pain Relevance 0.24
Oxidative stress and induction of cell death in HSC/MFs
Positive_regulation (induction) of MFs associated with stress and death
6) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.19 Pain Relevance 0.13
Pro-inflammatory response of activated HSC/MFs to ROS and HNE: the strange case of MCP-1
Positive_regulation (activated) of MFs associated with inflammatory response
7) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.78 Pain Relevance 0.19
Up-regulation of pro-collagen type I by both ROS and HNE in activated HSC/MFs is a relevant finding that has been confirmed by several different laboratories using either cells of human or rat origin.
Positive_regulation (activated) of MFs
8) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.51 Pain Relevance 0
ROS generated within HSC/MFs up-regulate collagen type I: the focus is now within the target pro-fibrogenic cell
Positive_regulation (generated) of MFs
9) Confidence 0.00 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.35 Pain Relevance 0.05

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