INT52442

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Context Info
Confidence 0.35
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.05
Pain Relevance 8.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
poly 1
arterioles 1
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 100.00 Very High Very High Very High
Pain 36 100.00 Very High Very High Very High
Analgesic 11 100.00 Very High Very High Very High
aspirin 9 100.00 Very High Very High Very High
Hyperalgesia 6 99.90 Very High Very High Very High
cINOD 62 99.66 Very High Very High Very High
COX2 25 99.46 Very High Very High Very High
cOX1 9 99.46 Very High Very High Very High
narcan 2 99.46 Very High Very High Very High
tramadol 8 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 74 100.00 Very High Very High Very High
INFLAMMATION 72 100.00 Very High Very High Very High
Pain 39 100.00 Very High Very High Very High
Fever 2 100.00 Very High Very High Very High
Hyperalgesia 6 99.90 Very High Very High Very High
Colon Cancer 1 98.16 Very High Very High Very High
Nociception 13 96.56 Very High Very High Very High
Wound Healing 44 96.08 Very High Very High Very High
Cancer 8 96.08 Very High Very High Very High
Osteoarthritis 46 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions of PGH synthase isozymes-1 and -2 with NSAIDs.
PGH synthase isozymes-1 Binding (Interactions) of associated with cinod
1) Confidence 0.35 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 7825862 Disease Relevance 0.29 Pain Relevance 0.37
Structural modeling and biochemical assays showed the ability of PGHS1 and PGHS2 to heterodimerize and form prostaglandins.
PGHS1 Binding (heterodimerize) of
2) Confidence 0.34 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.33 Pain Relevance 0.38
Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice.
cyclooxygenase Binding (interaction) of associated with tramadol and cox1
3) Confidence 0.29 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 15276689 Disease Relevance 0.19 Pain Relevance 1.74
Furthermore, the results indicate that known NSAIDs differ in their interaction with cyclooxygenase, being able to inhibit either COX2 enzymatic activity, and/or COX2 expression.
cyclooxygenase Binding (interaction) of associated with cinod and cox2
4) Confidence 0.17 Published 1995 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7766705 Disease Relevance 0.30 Pain Relevance 1.30
NSAID-related gastric damage is caused by inhibition of cyclooxygenase-1 (COX-1) and prostaglandins, which help to maintain GI mucosal integrity.
cyclooxygenase-1 Neg (inhibition) Binding (inhibition) of associated with cinod
5) Confidence 0.11 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2322990 Disease Relevance 1.63 Pain Relevance 1.68
Since cyclooxygenase, the enzyme initiating their biosynthesis, is inhibited by aspirin-like antipyretic, anti-inflammatory, and analgesic drugs, contribution of prostanoids to acute inflammation such as fever generation, pain sensitization, and inflammatory swelling has been recognized very early.
cyclooxygenase Binding (recognized) of associated with pain, aspirin, pressure and volume under development, inflammation, analgesic and fever
6) Confidence 0.08 Published 2009 Journal J. Mol. Med. Section Abstract Doc Link 19609495 Disease Relevance 0.95 Pain Relevance 0.57
BACKGROUND: Most nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1), whose inhibition is associated with gastrointestinal ulceration, and COX-2, whose inhibition is associated with therapeutic benefits.
cyclooxygenase-1 Binding (associated) of associated with inflammation and cinod
7) Confidence 0.05 Published 2000 Journal Ann. Intern. Med. Section Abstract Doc Link 10877734 Disease Relevance 0.10 Pain Relevance 0.20
BACKGROUND: Most nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1), whose inhibition is associated with gastrointestinal ulceration, and COX-2, whose inhibition is associated with therapeutic benefits.
cyclooxygenase-1 Binding (associated) of associated with inflammation and cinod
8) Confidence 0.05 Published 2000 Journal Ann. Intern. Med. Section Abstract Doc Link 10877734 Disease Relevance 0.10 Pain Relevance 0.20
Treatment with the nonselective cyclooxygenase (COX) inhibitor carprofen prevents poly(I ? 
cyclooxygenase Binding (Treatment) of in poly
9) Confidence 0.05 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.46 Pain Relevance 0.22
Increases in astrocyte Ca2+ have also been reported to dilate arterioles via cyclooxygenase mediated formation of prostaglandin E2 [41], [42], [43].
cyclooxygenase Binding (formation) of in arterioles
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.59 Pain Relevance 0
We examined whether nitric oxide (NO), derived from constitutive NO synthase (NOS) and/or inducible NOS (iNOS), could contribute to endotoxin-induced inflammatory hyperalgesia via interacting with nuclear factor-kappaB (NF-kappaB), inducible cyclooxygenase (COX-2) and/or polyADP-ribose synthase (PARS).
cyclooxygenase Binding (interacting) of associated with hyperalgesia and inflammation
11) Confidence 0.03 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 16310374 Disease Relevance 0.44 Pain Relevance 0.46
The selective inhibitors of phospholipase A2, 4-bromophenacyl bromide (300 µM), and of cyclooxygenase, indomethacin (10 µM), prevented the swelling of Müller cells from Dp71-null mice (Fig. 5C; 103.3±2.1%, n?
cyclooxygenase Binding (indomethacin) of associated with pressure and volume under development
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.80 Pain Relevance 0.30
COX: cyclooxygenase; CYP: cytochrome P450; IOD: integrated optical density; GC-MS: gas chromatography-mass spectrometry; LOX: lipoxygenase; MUFA: monounsaturated fatty acid; MVD: Micro vessel density; PUFA: polyunsaturated fatty acid; ROS: reactive oxygen species; RT-PCR: reverse transcriptase polymerase chain reaction; VEGFA: vascular endothelial growth factor A; AKT1: v-akt murine thymoma viral oncogene homolog 1.


cyclooxygenase Binding (cytochrome P450) of associated with thymoma
13) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.58 Pain Relevance 0
COX: cyclooxygenase; CYP: cytochrome P450; IOD: integrated optical density; GC-MS: gas chromatography-mass spectrometry; LOX: lipoxygenase; MUFA: monounsaturated fatty acid; MVD: Micro vessel density; PUFA: polyunsaturated fatty acid; ROS: reactive oxygen species; RT-PCR: reverse transcriptase polymerase chain reaction; VEGFA: vascular endothelial growth factor A; AKT1: v-akt murine thymoma viral oncogene homolog 1.


cyclooxygenase Binding (COX) of associated with thymoma
14) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.58 Pain Relevance 0
In these species, R-flurbiprofen is not inverted to its cyclooxygenase inhibiting S-enantiomer.
cyclooxygenase Binding (inverted) of
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 1.09 Pain Relevance 0.90
NSAIDs nonselectively inhibit both the constitutive cyclooxygenase (COX) 1 associated with side effects and the desired therapeutic target COX-2, which is induced in inflammation and neoplasia.
constitutive cyclooxygenase Binding (associated) of associated with inflammation, cancer and cinod
16) Confidence 0.01 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11016626 Disease Relevance 0.63 Pain Relevance 0.46

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