INT52457

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 129
Total Number 132
Disease Relevance 38.68
Pain Relevance 19.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
MDCK 6
pancreas 6
kidney 5
intestine 3
livers 3
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 51 100.00 Very High Very High Very High
cINOD 94 99.84 Very High Very High Very High
antagonist 11 99.76 Very High Very High Very High
opiate 9 99.56 Very High Very High Very High
opioid receptor 2 99.54 Very High Very High Very High
tolerance 42 99.46 Very High Very High Very High
aspirin 26 99.36 Very High Very High Very High
rheumatoid arthritis 30 99.24 Very High Very High Very High
qutenza 49 99.06 Very High Very High Very High
COX-2 inhibitor 5 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 277 100.00 Very High Very High Very High
Cancer 653 99.96 Very High Very High Very High
Lymphatic System Cancer 9 99.86 Very High Very High Very High
Parathyroid Cancer 18 99.80 Very High Very High Very High
INFLAMMATION 94 99.72 Very High Very High Very High
Uterine Cancer 2 99.58 Very High Very High Very High
Injury 391 99.56 Very High Very High Very High
Apoptosis 88 99.52 Very High Very High Very High
Rheumatoid Arthritis 30 99.24 Very High Very High Very High
Nephrotoxicity 13 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of both P-gp activity and P-gp expression by Devil's Claw raise the possibility of herb-drug interactions, to be further explored in depth.


Gene_expression (expression) of P-gp in Claw
1) Confidence 0.78 Published 2009 Journal Phytomedicine Section Body Doc Link 19577448 Disease Relevance 0.10 Pain Relevance 0
MATERIALS AND METHODS: The effects of three commercially available Devil's Claw preparations and that of pure harpagoside were studied in the human kidney (HK-2) proximal tubule cell line, constitutively expressing ABCB1/P-glycoprotein (P-gp).
Gene_expression (expressing) of P-gp in HK-2
2) Confidence 0.78 Published 2009 Journal Phytomedicine Section Body Doc Link 19577448 Disease Relevance 0.16 Pain Relevance 0
Observation of this similar response between these two in vitro trophoblast models is promising for assessment between P-gp expression and activity of drugs towards placental function.
Gene_expression (expression) of P-gp
3) Confidence 0.77 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19840843 Disease Relevance 0 Pain Relevance 0.11
Overexpression of the ABCB1 gene within drug-sensitive cells or mice to produce transgenic animals confers resistance to the agents described [28], [29].
Gene_expression (Overexpression) of ABCB1 gene associated with targeted disruption
4) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.43 Pain Relevance 0
In this study, multi-drug resistant osteosarcoma cell lines (KHOSR2 and U-2OSR2) were treated with the MDR1 siRNA nanocarriers and MDR1 protein (P-gp) expression, drug retention, and immunofluoresence were analyzed.
Gene_expression (expression) of MDR1 associated with osteogenic sarcomas
5) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2875382 Disease Relevance 0.30 Pain Relevance 0
We observed that MDR1 siRNA loaded dextran nanoparticles efficiently suppresses P-gp expression in the drug resistant osteosarcoma cell lines.
Gene_expression (expression) of P-gp associated with osteogenic sarcomas
6) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2875382 Disease Relevance 0.29 Pain Relevance 0
Previously, we have demonstrated that both synthetic-based and plasmid-based siRNA can significantly block MDR1 expression in drug resistant cell lines [15].
Gene_expression (expression) of MDR1
7) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.21 Pain Relevance 0
In this study, multi-drug resistant osteosarcoma cell lines (KHOSR2 and U-2OSR2) were treated with the MDR1 siRNA nanocarriers and MDR1 protein (P-gp) expression, drug retention, and immunofluoresence were analyzed.
Gene_expression (expression) of P-gp associated with osteogenic sarcomas
8) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2875382 Disease Relevance 0.30 Pain Relevance 0
Our results showed that by treating drug resistant osteosarcoma cell lines with MDR1 siRNA nanoparticles at concentrations of 30 nM or higher, the expression of P-gp was effectively suppressed in both the KHOSR2 and the U-2OSR2 cells.
Gene_expression (expression) of P-gp associated with osteogenic sarcomas
9) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.62 Pain Relevance 0
Although P-gp expression in these tissues is relatively low, it may play an important role in protecting rapidly dividing cells from toxicity after exposure to anticancer drugs [42].
Gene_expression (expression) of P-gp associated with toxicity
10) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.43 Pain Relevance 0.05
However, multidrug resistant cells expressing high levels of P-gp rapidly extrude non-fluorescent calcein AM from the plasma membrane, reducing accumulation of fluorescent calcein in the cytosol.
Gene_expression (expressing) of P-gp in plasma
11) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
In addition, MDR1 siRNA loaded nanoparticles were able to suppress the expression of P-gp for a longer period of time compared to MDR1 siRNA transfected with commercially available agents (96 hr compared to 48 hr).
Gene_expression (expression) of P-gp
12) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.58 Pain Relevance 0.03
The biliary route seems to represent an important pathway for PQ excretion due to the strong expression of P-glycoprotein (P-gp) at the canalicular membrane of hepatocytes [33], [34] and PQ has been recovered in the bile postmortem samples [35].
Gene_expression (expression) of P-gp in bile associated with bile
13) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745573 Disease Relevance 0.82 Pain Relevance 0.31
One of the underlying mechanisms of MDR is cellular overproduction of P-glycoprotein (P-gp) which acts as an efflux pump for various anticancer drugs.
Gene_expression (overproduction) of P-gp
14) Confidence 0.75 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16842217 Disease Relevance 0.19 Pain Relevance 0
Although recent studies state that expression of P-glycoprotein (P-gp) in parathyroid tumors plays an important role in the false-negative results of both 99mTc-MIBI scans and FDG-PET, immunohistological study detected no P-gp expression in the parathyroid tumor in the current case.
Gene_expression (expression) of P-glycoprotein in parathyroid associated with parathyroid cancer
15) Confidence 0.75 Published 2004 Journal Intern. Med. Section Abstract Doc Link 15497517 Disease Relevance 1.36 Pain Relevance 0.21
Although recent studies state that expression of P-glycoprotein (P-gp) in parathyroid tumors plays an important role in the false-negative results of both 99mTc-MIBI scans and FDG-PET, immunohistological study detected no P-gp expression in the parathyroid tumor in the current case.
Gene_expression (expression) of P-gp in parathyroid associated with parathyroid cancer
16) Confidence 0.75 Published 2004 Journal Intern. Med. Section Abstract Doc Link 15497517 Disease Relevance 1.36 Pain Relevance 0.21
To further investigate the cell death-inducing mechanisms of NCX 4040, we analyzed gp-170, caspase expression and mitochondrial membrane potential (Delta Psi) depolarization.
Gene_expression (expression) of gp-170 associated with death
17) Confidence 0.75 Published 2005 Journal Apoptosis Section Abstract Doc Link 16151642 Disease Relevance 0.80 Pain Relevance 0.31
Moreover, it has been suggested that COX-2 inhibitors may contribute to maintain high levels of chemotherapeutics in tumor tissues by preventing the overexpression of the multidrug resistance protein MDR1/P-gp.
Gene_expression (overexpression) of P-gp associated with cancer and cox-2 inhibitor
18) Confidence 0.75 Published 2005 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15850674 Disease Relevance 0.88 Pain Relevance 0.59
The observed asymmetry in methadone transfer could be explained by the unidirectional activity of the efflux transporter P glycoprotein (P-gp) that is highly expressed in variable amounts in trophoblast tissue.
Gene_expression (expressed) of P-gp associated with methadone
19) Confidence 0.75 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15588727 Disease Relevance 0 Pain Relevance 0.91
The biliary route seems to represent an important pathway for PQ excretion due to the strong expression of P-glycoprotein (P-gp) at the canalicular membrane of hepatocytes [33], [34] and PQ has been recovered in the bile postmortem samples [35].
Gene_expression (expression) of P-glycoprotein in bile associated with bile
20) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745573 Disease Relevance 0.82 Pain Relevance 0.31

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