INT52460

Context Info Confidence 0.67 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 2.50 Pain Relevance 0.86

mitochondrion (SUCLA2) small molecule metabolic process (SUCLA2) ligase activity (SUCLA2)

Anatomy Link Frequency plasma 1 SUCLA2 (Homo sapiens)

Pain Link Frequency Relevance Heat mu opioid receptor 1 98.04 Bioavailability 2 96.22 Inflammation 6 93.12 Opioid 4 92.32 Pain 1 85.84 cINOD 1 77.84 tolerance 1 77.84 adenocard 1 75.00 peripheral neuropathy 8 72.40 cytokine 1 25.00

Disease Link Frequency Relevance Heat Hypersensitivity 1 99.42 Stress 14 95.16 INFLAMMATION 7 93.12 Disease 47 88.92 Diabetes Mellitus 9 88.64 Fever 1 86.24 Pain 1 85.84 Ulcers 1 83.88 Parkinson's Disease 6 82.92 Syndrome 6 81.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).

Localization (accumulation) of SUCLA2

1) Confidence 0.67 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.66 Pain Relevance 0.07

The aim of the present study in 12 healthy subjects was to compare the oral bioavailability of 20 mg piroxicam in a CHF1194 tablet and a plain piroxicam capsule after a single dose and after two weeks of once daily administration, and also to assess the plasma levels and urinary excretion of beta-cyclodextrin after CHF1194 administration.

Localization (excretion) of beta-cyclodextrin in plasma associated with bioavailability

2) Confidence 0.53 Published 1995 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 7768257 Disease Relevance 0.08 Pain Relevance 0.20

Moreover, it has been demonstrated that, in the presence of A-beta, insulin prevents the decline in mitochondrial oxidative phosphorylation efficiency and avoids an increase in oxidative stress [24].

Localization (presence) of A-beta associated with stress

3) Confidence 0.18 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.09 Pain Relevance 0

We also measured its anti-allergic effect by its inhibition of beta-hexosamidase release.

Localization (release) of beta-hexosamidase associated with hypersensitivity

4) Confidence 0.01 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.60 Pain Relevance 0.21

Human beta-casomorphin-4 and soymorphin-5 were released from the soy 7S fraction (beta-conglycinin) by the action of gastrointestinal proteases.

Localization (released) of beta-conglycinin

5) Confidence 0.01 Published 2007 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 17928679 Disease Relevance 0.07 Pain Relevance 0.38

General Comments

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