INT52464

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 8.71
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
brain 1
DRG 1
femur 1
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 96 100.00 Very High Very High Very High
B1 receptor 17 100.00 Very High Very High Very High
dorsal root ganglion 5 99.44 Very High Very High Very High
unmyelinated 2 99.36 Very High Very High Very High
Cancer pain 14 99.30 Very High Very High Very High
Pain 10 98.96 Very High Very High Very High
Thermal hyperalgesia 2 98.84 Very High Very High Very High
b2 receptor 34 98.24 Very High Very High Very High
Hyperalgesia 7 98.08 Very High Very High Very High
Inflammation 64 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.44 Very High Very High Very High
Nervous System Injury 3 99.36 Very High Very High Very High
Hypersensitivity 3 99.32 Very High Very High Very High
Bone Cancer 16 99.20 Very High Very High Very High
Sarcoma 2 99.18 Very High Very High Very High
Pain 9 98.96 Very High Very High Very High
Hyperalgesia 11 98.84 Very High Very High Very High
Obesity 1 97.92 Very High Very High Very High
Encephalitis 1 97.60 Very High Very High Very High
Targeted Disruption 14 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our model of bone cancer, which involves the injection and confinement of 2472 sarcoma cells to the mouse femur, pharmacologic blockade of the bradykinin B1 receptor is effective in reducing pain-related behaviors at both early and advanced stages of bone cancer.
Negative_regulation (blockade) of bradykinin B1 receptor in femur associated with pain, sarcoma, b1 receptor and bone cancer
1) Confidence 0.57 Published 2005 Journal J Pain Section Abstract Doc Link 16275602 Disease Relevance 1.75 Pain Relevance 1.31
With a mouse model of bone cancer pain we demonstrate that pharmacologic blockade of the bradykinin B1 receptor is effective in reducing bone cancer pain-related behaviors, suggesting that B1 antagonists might be useful in attenuating bone cancer pain in humans.
Negative_regulation (blockade) of bradykinin B1 receptor associated with cancer pain, antagonist, b1 receptor and bone cancer
2) Confidence 0.57 Published 2005 Journal J Pain Section Abstract Doc Link 16275602 Disease Relevance 1.70 Pain Relevance 1.32
We previously have observed that B1R deletion increased HO-1 and decreased MCP-1 expression [27].
Negative_regulation (deletion) of B1R
3) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.44 Pain Relevance 0.43
Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity.
Negative_regulation (deficiency) of B1 receptor associated with b1 receptor, obesity and hypersensitivity
4) Confidence 0.37 Published 2008 Journal Diabetes Section Title Doc Link 18332096 Disease Relevance 0.48 Pain Relevance 0.19
Treatment of wild-type mice with the selective B(1) antagonist des-Arg(9)-[Leu(8)]-BK (150 nmol/kg, s.c.) reduced CFA-evoked thermal hyperalgesia, to an extent which was similar to that observed in mice lacking kinin B(1) receptor.
Negative_regulation (lacking) of kinin B associated with thermal hyperalgesia and antagonist
5) Confidence 0.35 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11747905 Disease Relevance 1.00 Pain Relevance 0.52
Neurotropin, an inhibitor of the kallikrein-kinin system, was therapeutically i.p. administered to mice with brain inflammation induced by subarachnoidal injection of carrageenan.
Negative_regulation (inhibitor) of kallikrein-kinin in brain associated with inflammation and encephalitis
6) Confidence 0.35 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7768286 Disease Relevance 0.17 Pain Relevance 0.08
Gene disruption of the kinin B(2) receptor did not interfere with CFA-induced hyperalgesia, but ablation of the gene of the B(1) receptor reduced the hyperalgesia in both ipsilateral (48+/-13%, at 12 h) and contralateral (91+/-22%, at 12 h) paws.
Negative_regulation (disruption) of kinin B associated with hyperalgesia
7) Confidence 0.31 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11747905 Disease Relevance 0.82 Pain Relevance 0.43
We found that in sham-operated mice mainly B2 receptors were expressed in unmyelinated DRG neurons with a very little presence of B1 receptor.
Neg (little) Negative_regulation (presence) of B1 receptor in DRG associated with dorsal root ganglion, b1 receptor and unmyelinated
8) Confidence 0.23 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 1.20 Pain Relevance 1.30
Our results show that SP600125 abolished the nicotine-enhanced kinin receptor-mediated contractions and the receptor mRNA expression.
Negative_regulation (abolished) of kinin associated with nicotine
9) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.15 Pain Relevance 0.31

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