INT52484

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.26
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PTPRU) cell adhesion (PTPRU) plasma membrane (PTPRU)
Anatomy Link Frequency
chromaffin cells 2
PTPRU (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 28 99.98 Very High Very High Very High
Neuropeptide 4 98.36 Very High Very High Very High
Neurotransmitter 7 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 2 93.44 High High
Paralysis 1 79.20 Quite High
Obesity 14 5.00 Very Low Very Low Very Low
Toxicity 9 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Bites And Stings 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of PTP synthesis was involved in the forskolin-induced increase in PTP activity, as demonstrated by a 10-fold increase in [35S]PTP pulse labeling in forskolin-treated chromaffin cells.
Gene_expression (synthesis) of PTP in chromaffin cells
1) Confidence 0.47 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.45
PTP, it is quite possible that the state IRi?
Spec (possible) Gene_expression (possible) of PTP
2) Confidence 0.46 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
These results demonstrate a role for PTP in proenkephalin processing in chromaffin cells and indicate that [Met] enkephalin formation and PTP are both regulated by cAMP.
Gene_expression (formation) of PTP in chromaffin cells associated with enkephalin
3) Confidence 0.40 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.33
The novel "prohormone thiol protease" (PTP) has been proposed as a candidate proenkephalin processing enzyme for the production of [Met]enkephalin in chromaffin granules (Krieger, T.
Gene_expression (production) of PTP associated with enkephalin
4) Confidence 0.40 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.46
Forskolin elevation of PTP protein levels within chromaffin granules was also detected in Western blots.
Gene_expression (levels) of PTP protein
5) Confidence 0.40 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.42
Although C. elegans also expresses neurexin and PTP?
Gene_expression (expresses) of PTP
6) Confidence 0.03 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0.26 Pain Relevance 0

General Comments

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