INT5249

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 23
Disease Relevance 10.39
Pain Relevance 6.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hrasls)
Anatomy Link Frequency
cerebral cortex 6
cerebellum 6
paw 2
cardiomyocytes 1
yolk 1
Hrasls (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 592 99.84 Very High Very High Very High
antidepressant 49 99.50 Very High Very High Very High
Dopamine 624 99.26 Very High Very High Very High
Neurotransmitter 184 99.00 Very High Very High Very High
Glutamate 42 99.00 Very High Very High Very High
Clonidine 4 98.00 Very High Very High Very High
cINOD 2 97.00 Very High Very High Very High
Inflammation 21 91.24 High High
monoamine 14 85.32 High High
dexamethasone 4 78.88 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 35 99.92 Very High Very High Very High
Diabetes Mellitus 1440 99.80 Very High Very High Very High
INFLAMMATION 24 99.08 Very High Very High Very High
Cognitive Disorder 177 98.56 Very High Very High Very High
Apoptosis 64 85.52 High High
Stroke 20 70.08 Quite High
Stress 145 67.52 Quite High
Shock 36 60.68 Quite High
Drug Dependence 32 55.92 Quite High
Urological Neuroanatomy 7 55.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, a new model developed in our laboratory, which was obtained by phospholipase A2 intracerebral injection was used to study the antiinflammatory effect of clonidine.
Gene_expression (injection) of phospholipase associated with inflammation and clonidine
1) Confidence 0.58 Published 1992 Journal Agents Actions Section Abstract Doc Link 1295375 Disease Relevance 0.52 Pain Relevance 0.38
Injection of phospholipase A2 (Naja naja, 2.5-20 U/paw) and phospholipase C (Clostridium perfringens, 0.03-0.05 U/paw) caused a dose-and-time-related increase in paw oedema.
Gene_expression (Injection) of phospholipase in paw associated with pressure and volume under development
2) Confidence 0.55 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8276072 Disease Relevance 0.70 Pain Relevance 0.13
Injection of phospholipase A2 (Naja naja, 2.5-20 U/paw) and phospholipase C (Clostridium perfringens, 0.03-0.05 U/paw) caused a dose-and-time-related increase in paw oedema.
Gene_expression (Injection) of phospholipase in paw associated with pressure and volume under development
3) Confidence 0.55 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8276072 Disease Relevance 0.72 Pain Relevance 0.13
RESULTS: Spinal delivery of L-alpha-phosphatidylcholine of egg yolk (L-EPC) and the phospholipase hydrolysis product (lyso-L-alpha-phosphatidylcholine [lyso-L-EPC]) produced dose-dependent touch-evoked agitation; the order of potency and rapidity of onset was lyso-L-EPC > L-EPC, with no difference in activity whether administered as an emulsion or as a liposome preparation.
Gene_expression (produced) of phospholipase in yolk
4) Confidence 0.51 Published 1995 Journal Anesthesiology Section Body Doc Link 7741294 Disease Relevance 0 Pain Relevance 0
Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties.

Gene_expression (expression) of phospholipase in cerebral cortex associated with inflammation, diabetes mellitus and cerebral cortex
5) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2890658 Disease Relevance 0.61 Pain Relevance 0.37
In the present study, we determined diabetes-mediated alterations in phospholipase C expression in the cerebral cortex and cerebellum.
Gene_expression (expression) of phospholipase in cerebral cortex associated with diabetes mellitus and cerebral cortex
6) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.53 Pain Relevance 0.33
Altered phospholipase C expression fails to modulate the activity of downstream proteins important for cellular signalling.
Gene_expression (expression) of phospholipase
7) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.30 Pain Relevance 0.28
Our results showed a decreased expression of phospholipase C in the cerebral cortex and cerebellum of diabetic rats when compared to control.
Gene_expression (expression) of phospholipase in cerebellum associated with diabetes mellitus and cerebral cortex
8) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.50 Pain Relevance 0.29
Our results indicate that curcumin has a potential to regulate diabetes induced malfunctions of dopaminergic signalling, CREB and Phospholipase C expression in cerebral cortex and cerebellum and thereby improving the cognitive and emotional functions associated with these regions.
Gene_expression (expression) of Phospholipase in cerebellum associated with cognitive disorder, diabetes mellitus and cerebral cortex
9) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.77 Pain Relevance 0.42
These evidences led us to propose that the enhancement of diabetes-mediated phospholipase C gene expression could impart damage to the central cognitive functions; which has been found to be effectively protected by curcumin treatment.
Gene_expression (expression) of phospholipase associated with cognitive disorder and diabetes mellitus
10) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.38 Pain Relevance 0.24
Further studies are to be carried out to reveal the correlation between the expression of phospholipase C and G protein coupled neurotransmitter receptors.
Gene_expression (expression) of phospholipase associated with neurotransmitter
11) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.64 Pain Relevance 0.20
Defective expression of phospholipase C results in low levels of IP3 causing the impaired release of calcium and bring down the level of intracellular calcium and thus failed to execute the normal neuronal function in cerebral cortex and cerebellum.
Gene_expression (expression) of phospholipase in cerebral cortex associated with cerebral cortex
12) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.33 Pain Relevance 0.26
Activation of all the G protein coupled receptors including Ach, glutamate and dopamine results in second messenger enzyme, phospholipase C expression.
Gene_expression (expression) of phospholipase associated with dopamine and glutamate
13) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.31 Pain Relevance 0.24
Real Time-PCR analysis showed that the phospholipase C gene expression in the cerebral cortex and cerebellum was significantly decreased (p < 0.001) in diabetic condition.
Gene_expression (expression) of phospholipase in cerebral cortex associated with diabetes mellitus and cerebral cortex
14) Confidence 0.11 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.52 Pain Relevance 0.44
Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties.

Gene_expression (expression) of phospholipase in cerebellum associated with inflammation, diabetes mellitus and cerebral cortex
15) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2890658 Disease Relevance 0.61 Pain Relevance 0.37
Our results showed a decreased expression of phospholipase C in the cerebral cortex and cerebellum of diabetic rats when compared to control.
Gene_expression (expression) of phospholipase in cerebral cortex associated with diabetes mellitus and cerebral cortex
16) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.50 Pain Relevance 0.29
In the present study, we determined diabetes-mediated alterations in phospholipase C expression in the cerebral cortex and cerebellum.
Gene_expression (expression) of phospholipase in cerebellum associated with diabetes mellitus and cerebral cortex
17) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.53 Pain Relevance 0.33
Defective expression of phospholipase C results in low levels of IP3 causing the impaired release of calcium and bring down the level of intracellular calcium and thus failed to execute the normal neuronal function in cerebral cortex and cerebellum.
Gene_expression (expression) of phospholipase in cerebellum associated with cerebral cortex
18) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.33 Pain Relevance 0.26
Our results indicate that curcumin has a potential to regulate diabetes induced malfunctions of dopaminergic signalling, CREB and Phospholipase C expression in cerebral cortex and cerebellum and thereby improving the cognitive and emotional functions associated with these regions.
Gene_expression (expression) of Phospholipase in cerebral cortex associated with cognitive disorder, diabetes mellitus and cerebral cortex
19) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.77 Pain Relevance 0.42
Hence, while the antidepressants are able to enhance the production of substrate for the phospholipase C reaction, the drugs are apparently incapable by themselves to induce the breakdown of these substrates into active second messengers.
Gene_expression (production) of phospholipase associated with antidepressant
20) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2823756 Disease Relevance 0.06 Pain Relevance 0.45

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