INT52508

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 8.10
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
Anatomy Link Frequency
chondrocytes 4
bar 2
colon 1
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 195 99.74 Very High Very High Very High
rheumatoid arthritis 315 99.04 Very High Very High Very High
Osteoarthritis 221 96.80 Very High Very High Very High
methotrexate 25 94.72 High High
Inflammatory mediators 8 81.08 Quite High
cytokine 14 73.16 Quite High
Inflammation 45 61.56 Quite High
anesthesia 1 50.00 Quite Low
Arthritis 25 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 416 99.40 Very High Very High Very High
Rheumatoid Arthritis 315 99.04 Very High Very High Very High
Cancer 56 98.56 Very High Very High Very High
Overweight 52 98.36 Very High Very High Very High
Osteoarthritis 221 96.80 Very High Very High Very High
Recurrence 2 94.92 High High
Transitional Cell Carcinoma 26 94.24 High High
Bladder Cancer 29 90.92 High High
INFLAMMATION 54 80.68 Quite High
Body Weight 8 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antibodies from RA patients support metalloproteinase activity by neutralizing TIMP-2
Positive_regulation (neutralizing) of TIMP-2 associated with metalloproteinase and rheumatoid arthritis
1) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.79 Pain Relevance 0.49
Bearing in mind the significant difference in the pattern of erosivity between RA patients with and those without TIMP-2 specific autoantibodies, we decided to analyse whether these immunoglobulins supported MMP9 activity by neutralizing TIMP-2.
Spec (whether) Positive_regulation (neutralizing) of TIMP-2 associated with rheumatoid arthritis
2) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.44 Pain Relevance 0.30
After incubation, the immunoglobulin/TIMP-2 mixtures were then added to MMP9 (32 ng/ml) and activated with 1 mM p-aminophenylmercuric acid.
Positive_regulation (activated) of TIMP-2
3) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.17 Pain Relevance 0.09
Their studies revealed further elevated MMP2, MMP3, and TIMP2 concentrations from patients after tumour resection, which might function as a predictive value for early detection of tumour recurrence [20,40].
Positive_regulation (elevated) of TIMP2 associated with cancer and recurrence
4) Confidence 0.43 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.13 Pain Relevance 0.20
In contrast, IgG fractions from the controls had significantly less effect on TIMP-2 activity, and the residual TIMP-2 was sufficient to significantly reduce MMP9 activation from 100% to 37% (control 1, 10%; control 2, 45%) (Fig. 4, bar 3).


Positive_regulation (sufficient) of TIMP-2 in bar
5) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.21 Pain Relevance 0.10
In contrast, IgG fractions from the controls had significantly less effect on TIMP-2 activity, and the residual TIMP-2 was sufficient to significantly reduce MMP9 activation from 100% to 37% (control 1, 10%; control 2, 45%) (Fig. 4, bar 3).


Positive_regulation (activation) of TIMP-2 in bar
6) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.22 Pain Relevance 0.11
At the serosal side of the colon wall the tissue-PO2 increased from 34 to 51 mmHg after epidural bupivacaine, which is statistically significant.
Positive_regulation (increased) of tissue-PO2 in colon
7) Confidence 0.40 Published 1995 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Body Doc Link 7772654 Disease Relevance 0 Pain Relevance 0
By contrast, mRNA levels for TIMP-2 was markedly increased in leptin-treated chondrocytes compared with control cells.
Positive_regulation (increased) of TIMP-2 in chondrocytes
8) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.92 Pain Relevance 0.24
In addition, the gene encoding MMP-13 was identified as a target of leptin for chondrocytes originated from obese patients while mRNA level of TIMP-2 was increased in leptin-treated chondrocytes collected from normal or overweight patients.
Positive_regulation (increased) of TIMP-2 in chondrocytes associated with obesity and overweight
9) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911905 Disease Relevance 1.33 Pain Relevance 0.13
The RT-PCR analysis showed major changes between both groups with an elevated mRNA level of growth factors, aggrecan and TIMP-2 in chondrocytes from obese patients suggesting that the chondrocyte metabolic activity is increased with obesity.
Positive_regulation (elevated) of TIMP-2 in chondrocytes associated with obesity
10) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.66 Pain Relevance 0.19
The gene encoding TIMP-2 was induced in chondrocytes obtained from normal or overweight patients while mRNA level of MMP-13 or COX-2 was increased in leptin-treated chondrocytes collected from obese OA patients.
Positive_regulation (induced) of TIMP-2 in chondrocytes associated with obesity, osteoarthritis and overweight
11) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.23 Pain Relevance 0.12

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