INT52512

Context Info Confidence 0.41 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 21 Total Number 21 Disease Relevance 5.39 Pain Relevance 5.27

transmembrane transport (SLC43A3)

Anatomy Link Frequency neuronal 2 spike 1 muscle 1 brain 1 head 1 SLC43A3 (Homo sapiens)

Pain Link Frequency Relevance Heat cocaine 25 99.98 Pain 62 99.24 Intracerebroventricular 2 98.50 agonist 46 97.88 opiate 21 97.52 anesthesia 15 95.70 positron emission tomography 3 95.08 Hippocampus 18 86.60 qutenza 4 84.08 Thalamus 28 82.24

Disease Link Frequency Relevance Heat Sepsis 30 99.98 Anxiety Disorder 68 99.70 Syndrome 11 99.68 Convulsion 19 99.34 Shock 15 98.98 Nociception 5 97.20 Pain 16 96.16 Reprotox - General 1 2 93.76 Erectile Dysfunction 8 88.64 Myalgia 4 87.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Different patterns of EEG activity were superimposed on the similar background of EEG activation during and after warm and cold stimulations.

Positive_regulation (activation) of EEG

1) Confidence 0.41 Published 2005 Journal Int J Psychophysiol Section Body Doc Link 15598518 Disease Relevance 0 Pain Relevance 0

On the other hand, intracerebroventricular administration of cocaine (7.5, 15, or 30 micrograms) induced significant EEG activation without affecting ICP.

Positive_regulation (activation) of EEG associated with intracerebroventricular and cocaine

2) Confidence 0.40 Published 1996 Journal Synapse Section Abstract Doc Link 8923663 Disease Relevance 0.26 Pain Relevance 0.54

It is well-known from animal and human studies that, as a central nervous stimulant, cocaine induces electroencephalographic (EEG) desynchronization.

Positive_regulation (induces) of EEG associated with cocaine

3) Confidence 0.40 Published 1996 Journal Synapse Section Abstract Doc Link 8923663 Disease Relevance 0.33 Pain Relevance 0.31

There was a postnatal increase in EEG power as, before clamping, pups aged 5-7 days exhibited isoelectric traces, whereas those aged 12-14 days and 21-22 days had intermittent EEG activity where the power in all frequencies was significantly lower at the former than at the latter age.

Positive_regulation (increase) of EEG

4) Confidence 0.37 Published 2009 Journal Lab. Anim. Section Abstract Doc Link 19237459 Disease Relevance 0.09 Pain Relevance 0.09

Anesthesia was induced with propofol 2.5 mg/kg, fentanyl 3 micrograms/kg (followed by an infusion of 2 micrograms/kg/h), vecuronium 0.1 mg/kg, and maintained with a propofol infusion (250-300 micrograms/kg/min) sufficient to induce EEG silence.

Positive_regulation (induce) of EEG associated with anesthesia

5) Confidence 0.36 Published 1995 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 7772973 Disease Relevance 0 Pain Relevance 0.19

Although the painful and non-painful muscular stimulations evoked similar EEG topographic patterns, statistics demonstrated that distinct EEG activation over different areas of the head were induced by the painful and non-painful stimulation compared with the baselines.

Positive_regulation (activation) of EEG in head associated with pain

6) Confidence 0.34 Published 2001 Journal Exp Brain Res Section Abstract Doc Link 11713631 Disease Relevance 0.26 Pain Relevance 1.31

These results may imply that the painful and non-painful muscular stimulations evoke distinct EEG activation in different neural networks of the human brain and the intensity of nociceptive input from muscle may encode the variety of topographic EEG changes.

Positive_regulation (activation) of EEG in muscle associated with nociception and pain

7) Confidence 0.34 Published 2001 Journal Exp Brain Res Section Abstract Doc Link 11713631 Disease Relevance 0.62 Pain Relevance 1.43

(F) Two independent spatial clusters of EEG activation, fronto-temporal delta-theta-beta activities and posterior parietal alpha activities emerged during CPT.

Positive_regulation (activation) of EEG in parietal

8) Confidence 0.20 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 11927371 Disease Relevance 0.07 Pain Relevance 0

In healthy humans, increase of low frequencies in EEG show a clear correlation with decline of sustained attention, which is necessary in preceding memory efforts [25].

Positive_regulation (increase) of EEG

9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990767 Disease Relevance 0.07 Pain Relevance 0.08

Our results support earlier findings from intracerebral electrode recordings demonstrating that MST- and ECS- induced seizures elicit differential patterns of EEG activation.

Positive_regulation (activation) of EEG associated with convulsion and shock

10) Confidence 0.05 Published 2008 Journal Clin EEG Neurosci Section Abstract Doc Link 18751564 Disease Relevance 1.43 Pain Relevance 0.15

ATP-Dependent Infra-Slow (<0.1 Hz) Oscillations in Thalamic Networks An increasing number of EEG and resting state fMRI studies in both humans and animals indicate that spontaneous low frequency fluctuations in cerebral activity at <0.1 Hz (infra-slow oscillations, ISOs) represent a fundamental component of brain functioning, being known to correlate with faster neuronal ensemble oscillations, regulate behavioural performance and influence seizure susceptibility.

Positive_regulation (increasing) of EEG in brain associated with convulsion

11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2637539 Disease Relevance 0.15 Pain Relevance 0.14

2–4 Hz) spike/poly-spike wave (SW/PSW) complexes intermingled with fast (10–20 Hz) runs and which have been likened to the EEG activity that occurs during LGS in humans [24].

Positive_regulation (occurs) of EEG in spike associated with syndrome

12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0.41 Pain Relevance 0.11

Consistently with this the ISS reflects estimated periods of the mutual temporal stabilization of quasi-stationary segments (spatially remote events) in the multichannel EEG [15].

Positive_regulation (stabilization) of EEG

13) Confidence 0.02 Published 2008 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2695620 Disease Relevance 0 Pain Relevance 0

-opiate receptor agonists are uniformly sedative in man, dog and rabbit, they often have alerting effects, usually demonstrated as EEG activation, in cats, rats and mice.

Positive_regulation (activation) of EEG associated with agonist and opiate

14) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0.29 Pain Relevance 0.64

Furthermore, these findings provided a sensitive and mechanistic description of how the benzodiazepine class of sedative anxiolytics paradoxically increase EEG beta (15–25 Hz) power in moderate to high concentrations (Liley et al. 2003).

Positive_regulation (increase) of EEG associated with anxiety disorder

15) Confidence 0.01 Published 2008 Journal Cogn Neurodyn Section Body Doc Link PMC2585619 Disease Relevance 0.23 Pain Relevance 0.14

Interestingly, as in mammals, the first 2 hours of recovery sleep in sparrows were characterized by large increases in EEG power not only in the low frequency range, but also across most frequencies in the 10 to 20 Hz range.

Positive_regulation (increases) of EEG

16) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.35 Pain Relevance 0

In sparrows, the increase in EEG power in the spindle frequency range (12–16 Hz) is especially intriguing, because spindles were not detected by visual scoring.

Positive_regulation (increase) of EEG

17) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.13 Pain Relevance 0

It has recently been suggested, however, that prolonged wakefulness results in stronger cortico-cortical connections, which in turn would drive greater neuronal synchronization during sleep, leading to increased EEG power across all frequencies [17].

Positive_regulation (increased) of EEG in neuronal

18) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.17 Pain Relevance 0

High-amplitude, low-frequency EEG activity reached its peak during SWS, when the birds were motionless, with eyes always closed and head either positioned beneath the wing, hanging forward or tucked in tightly toward the body.

Positive_regulation (reached) of EEG in body

19) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.19 Pain Relevance 0

In the cat, it has been shown that cortical states characterized by high levels of EEG activation are associated with high amplitude, sustained gamma oscillations (Herculano-Houzel et al. 1999; Siegel and König 2003), suggesting that synchronization of spiking responses may be facilitated by oscillatory activity.

Positive_regulation (activation) of EEG

20) Confidence 0.01 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0

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