INT52524

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.17
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora3) plasma membrane (Adora3) signal transducer activity (Adora3)
Anatomy Link Frequency
jaw 1
Adora3 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 129 100.00 Very High Very High Very High
agonist 207 99.08 Very High Very High Very High
ischemia 1 88.72 High High
antagonist 34 60.40 Quite High
Clonidine 1 54.68 Quite High
Inflammation 8 53.28 Quite High
narcan 7 37.52 Quite Low
Spinal cord 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 8 99.36 Very High Very High Very High
Leukemia 2 89.36 High High
Cv Unclassified Under Development 3 88.72 High High
Cv General 2 Under Development 2 77.12 Quite High
Pressure Volume 2 Under Development 1 55.52 Quite High
Pulmonary Disease 2 55.28 Quite High
Asthma 2 53.60 Quite High
INFLAMMATION 8 53.28 Quite High
Cancer 22 52.72 Quite High
Ischemic Heart Disease 2 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trincavelli et al. studied the relationship between agonist-induced desensitization, internalization and resensitization of hA3R in transfected CHO cells.
Regulation (resensitization) of A3R associated with agonist
1) Confidence 0.44 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.27 Pain Relevance 0.33
The effects of adenosine A3 receptor stimulation on seizures in mice.
Regulation (effects) of A3 receptor associated with adenocard and convulsion
2) Confidence 0.38 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7774659 Disease Relevance 0.81 Pain Relevance 0.52
These results indicate that the MAPK cascade is involved in A3R regulation by a feedback mechanism which controls GRK2 activity and probably involves direct receptor phosphorylation [97].
Regulation (regulation) of A3R
3) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.09 Pain Relevance 0.11
In contrast, inactivation of either Hoxa2 or Krox20 impairs the rhythmic control of jaw opening, consistent with Hoxa2 being required for normal development of the trigeminal function [13] and Krox20 being a direct regulator of Hoxa2 in r3 [4,5].


Regulation (regulator) of r3 in jaw
4) Confidence 0.00 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0

General Comments

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