INT52529

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 5
Speculated 7
Reported most in Abstract
Documents 48
Total Number 56
Disease Relevance 26.20
Pain Relevance 20.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
macrophages 3
spinal cord 2
epithelial cells 2
fibroblasts 2
myocardium 1
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 143 100.00 Very High Very High Very High
Inflammatory response 22 100.00 Very High Very High Very High
aspirin 19 100.00 Very High Very High Very High
ketamine 8 100.00 Very High Very High Very High
Morphine 121 99.84 Very High Very High Very High
Paracetamol 21 99.84 Very High Very High Very High
electroacupuncture 16 99.80 Very High Very High Very High
Neuropathic pain 32 99.68 Very High Very High Very High
cINOD 19 99.58 Very High Very High Very High
chemokine 40 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 293 100.00 Very High Very High Very High
Neuropathic Pain 49 99.68 Very High Very High Very High
Injury 15 99.68 Very High Very High Very High
Adhesions 18 99.32 Very High Very High Very High
Apoptosis 20 99.24 Very High Very High Very High
Hemophilus Infection 267 99.12 Very High Very High Very High
Inflammatory Pain 3 99.00 Very High Very High Very High
Hypertrophy 1 98.84 Very High Very High Very High
Nervous System Injury 19 98.36 Very High Very High Very High
Infarction 1 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of NF-kappaB is complicated; in addition to being activated by canonical cytokine-mediated pathways, NF-kappaB is activated by many of the signal transduction cascades associated with the development of cardiac hypertrophy and response to oxidative stress.
Regulation (Regulation) of NF-kappaB associated with stress, coronary heart disease and cytokine
1) Confidence 0.61 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 1.55 Pain Relevance 0.23
The aqueous extract of corni fructus exerts anti-inflammatory and analgesic effects by suppressing COX-2 and iNOS expression through the down-regulation of NF-kappaB binding activity.
Regulation (regulation) of NF-kappaB associated with inflammation and analgesic
2) Confidence 0.58 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.29 Pain Relevance 0.51
Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-alpha and iNOS expression, which is mediated by NF-kappaB regulation, in RAW264.7 cells.
Regulation (regulation) of NF-kappaB associated with cox1
3) Confidence 0.54 Published 2009 Journal J Ethnopharmacol Section Title Doc Link 19393729 Disease Relevance 0.46 Pain Relevance 0.74
The transcription factor activator protein-1, NF-kappaB, and nuclear factor of activated T cells (NFAT) were negatively regulated by morphine.
Regulation (regulated) of NF-kappaB in T cells associated with morphine
4) Confidence 0.46 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.35 Pain Relevance 1.27
To investigate the involvement of nuclear factor kappa B1 (NF-kappaB1; p50/p105) in electroacupuncture (EA)-induced analgesia, 2 and 100 Hz EA stimulations were applied at acupoint ST36 (Zusanli) in NF-kappaB1 knockout mice.
Spec (investigate) Regulation (involvement) of nuclear factor kappa B1 associated with targeted disruption, electroacupuncture and analgesia
5) Confidence 0.45 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11834313 Disease Relevance 0.17 Pain Relevance 0.51
This study investigated whether ME10092 regulates the nuclear factor kappa B (NF-kappaB)-mediated signal transduction in vivo.
Spec (whether) Regulation (regulates) of nuclear factor kappa B
6) Confidence 0.44 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.36 Pain Relevance 0.19
This study investigated whether ME10092 regulates the nuclear factor kappa B (NF-kappaB)-mediated signal transduction in vivo.
Spec (whether) Regulation (regulates) of NF-kappaB
7) Confidence 0.44 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.36 Pain Relevance 0.20
To investigate the involvement of nuclear factor kappa B1 (NF-kappaB1; p50/p105) in electroacupuncture (EA)-induced analgesia, 2 and 100 Hz EA stimulations were applied at acupoint ST36 (Zusanli) in NF-kappaB1 knockout mice.
Spec (investigate) Regulation (involvement) of p50/p105 associated with targeted disruption, electroacupuncture and analgesia
8) Confidence 0.44 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11834313 Disease Relevance 0.17 Pain Relevance 0.51
Effect of acetylsalicylic acid on nuclear factor-kappaB activation and on late preconditioning against infarction in the myocardium.
Regulation (Effect) of nuclear factor-kappaB in myocardium associated with aspirin and infarction
9) Confidence 0.43 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 16116334 Disease Relevance 0.31 Pain Relevance 0.38
Focus formation of PDGF-B-chain-transformed mouse fibroblasts was suppressed by treatment with acetylsalicylic acid (ASA) and salicylic acid, which are known inhibitors of NF-kappaB activation, but other nonsteroidal anti-inflammatory drugs that do not have an effect on NF-kappaB activity did not affect focus formation in these cells.
Regulation (effect) of NF-kappaB in fibroblasts associated with aspirin, inflammation and cinod
10) Confidence 0.41 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 11855867 Disease Relevance 0.24 Pain Relevance 0.23
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
Regulation (regulation) of p50 associated with chemokine, paracetamol, inflammation and hepatotoxicity
11) Confidence 0.40 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 16081117 Disease Relevance 1.11 Pain Relevance 0.96
concentrations in the BALF, there was no significant effect of p50 deficiency (Figure 4D).
Neg (no) Regulation (effect) of p50
12) Confidence 0.39 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.21 Pain Relevance 0.40
Furthermore, we show the involvement of NF-kappaB and Egr-1 transcription factors in the transcriptional induction of these enzymes.
Regulation (involvement) of NF-kappaB
13) Confidence 0.36 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.38 Pain Relevance 0.15
Many of these adhesion molecules and their inducers are under the control of inflammatory response transcriptional factors such as NF kappa B and AP-1.
Regulation (control) of NF kappa B associated with inflammatory response and adhesions
14) Confidence 0.32 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.89 Pain Relevance 0.41
Taken together, our data indicate that the p50 subunit of NF-kappaB is of importance in acute and persistent inflammatory pain.
Regulation (importance) of p50 subunit associated with ipn
15) Confidence 0.27 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17217946 Disease Relevance 1.24 Pain Relevance 0.78
Consequently, large efforts have been devoted to the study of the pharmacologic modulation of the NF-kappaB pathways.
Regulation (modulation) of NF-kappaB
16) Confidence 0.27 Published 2006 Journal Osteoarthr. Cartil. Section Abstract Doc Link 16730463 Disease Relevance 1.02 Pain Relevance 0.52
EMSA analysis showed that NF-kappa B translocation and its DNA binding activity were markedly increased by NTHi within 90 mins, and DNA binding activity of NF-kappa B was not affected by pre-treatment of specific p38 MAPK inhibitor SB203580.
Neg (not) Regulation (affected) of NF-kappa B associated with hemophilus infection
17) Confidence 0.27 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.16 Pain Relevance 0
Neither cardiac MAP kinases nor NFkappaB were influenced by the interventions.
Neg (Neither) Regulation (influenced) of NFkappaB
18) Confidence 0.27 Published 2005 Journal Lab. Anim. Section Abstract Doc Link 16004689 Disease Relevance 0.14 Pain Relevance 0.18
The transcription factor NF-kappaB is a central regulator of immunity, and of the NF-kappaB family, RelB is particularly involved in the expression of genes important in immune responses.
Regulation (regulator) of NF-kappaB
19) Confidence 0.26 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.05 Pain Relevance 0.56
The transcription factor NF-kappaB is a central regulator of immunity, and of the NF-kappaB family, RelB is particularly involved in the expression of genes important in immune responses.
Regulation (regulator) of NF-kappaB
20) Confidence 0.26 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.05 Pain Relevance 0.52

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