INT52530

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 4.41
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
smooth muscle 2
bone marrow 2
neutrophil 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 88 100.00 Very High Very High Very High
qutenza 1 100.00 Very High Very High Very High
chemokine 29 99.88 Very High Very High Very High
Morphine 4 99.44 Very High Very High Very High
Inflammation 200 98.96 Very High Very High Very High
Inflammatory response 21 98.56 Very High Very High Very High
Opioid 4 75.04 Quite High
metalloproteinase 2 64.96 Quite High
Chronic pancreatitis 2 50.00 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 222 98.96 Very High Very High Very High
Cancer 76 98.60 Very High Very High Very High
Brain Injury 83 97.00 Very High Very High Very High
Disease 42 96.40 Very High Very High Very High
Atherosclerosis 44 94.60 High High
Necrosis 11 94.16 High High
Obesity 9 91.64 High High
Adhesions 17 90.16 High High
Pneumonia 21 89.12 High High
Neutropenia 5 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While normal NF-kappaB activation is necessary for cell survival and immunity, deregulated NF-kappaB expression is a characteristic phenomenon in cancer development, as well as in several inflammatory diseases.
Regulation (deregulated) of Gene_expression (expression) of NF-kappaB associated with inflammation, cancer and disease
1) Confidence 0.59 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17919455 Disease Relevance 0.39 Pain Relevance 0.10
Effect of p50 deficiency on LPS-induced neutrophil recruitment in the absence of IL-6
Regulation (Effect) of Gene_expression (deficiency) of p50 in neutrophil
2) Confidence 0.39 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.89 Pain Relevance 0.34
Interestingly, a role for NF-kappaB regulating VCAM1 expression has been proposed [33].
Regulation (regulating) of Gene_expression (expression) of NF-kappaB
3) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.27 Pain Relevance 0.12
Interestingly, a role for NF-kappaB regulating VCAM1 expression has been proposed [33].
Regulation (role) of Gene_expression (expression) of NF-kappaB
4) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.27 Pain Relevance 0.12
For the three cell lines used, differential expression of the genes included in the GO categories "positive regulation of JNK cascade" and "positive regulation of I-kappaB kinase/NF-kappaB cascade" in the 1 h to 3 h comparison is also displayed in a heat map in Figure 5.
Regulation (regulation) of Gene_expression (cascade) of NF-kappaB
5) Confidence 0.18 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
Interestingly, positive regulation of two distinct signaling pathways, "positive regulation of I-kappaB kinase/NF-kappaB cascade" and "positive regulation of JNK cascade", was identified by the enrichment analysis in the comparison of 1 h and 3 h of TNF?
Regulation (regulation) of Gene_expression (cascade) of NF-kappaB
6) Confidence 0.18 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.09 Pain Relevance 0
Alteration of nuclear factor-kappaB (NF-kappaB) expression in bone marrow stromal cells treated with etoposide.
Regulation (Alteration) of Gene_expression (expression) of nuclear factor-kappaB in bone marrow associated with qutenza
7) Confidence 0.17 Published 2001 Journal Biochem. Pharmacol. Section Title Doc Link 11322928 Disease Relevance 0.09 Pain Relevance 0.10
Via negative regulation of nuclear factor-kappa B and activator protein-1 signaling pathways, PPAR alpha inhibits expression of inflammatory genes, such as interleukin-6, cyclooxygenase-2, and endothelin-1.
Regulation (regulation) of Gene_expression (pathways) of nuclear factor-kappa B associated with inflammation
8) Confidence 0.08 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.84 Pain Relevance 0.16
In this work, we investigated the effect of NAC administration on cortical expressions of nuclear factor kappa B (NF-?
Spec (investigated) Regulation (effect) of Gene_expression (expressions) of nuclear factor kappa B
9) Confidence 0.06 Published 2008 Journal Mediators of Inflammation Section Abstract Doc Link PMC2375967 Disease Relevance 1.51 Pain Relevance 0.22
Chronic ethanol intake did not elicit any change in the expression of alpha-smooth muscle actin, cyclooxygenase 2, toll-like receptor 4, nuclear factor kappaB, pancreatic collagen, and superoxide dismutase.
Regulation (change) of Gene_expression (expression) of nuclear factor kappaB in smooth muscle
10) Confidence 0.04 Published 2008 Journal Pancreas Section Body Doc Link 18665082 Disease Relevance 0.07 Pain Relevance 0
In the present investigation, infrequent and chronic (daily) exposure of rhesus monkeys to morphine was investigated for their effect on cytokine receptor expression, interleukin (IL)-2-production, and the nuclear factor kappa B (NF kappa B) levels following stimulation with PWM.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of nuclear factor kappa B associated with cytokine and morphine
11) Confidence 0.03 Published 1995 Journal Int. J. Neurosci. Section Abstract Doc Link 7775068 Disease Relevance 0 Pain Relevance 0.52

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