INT52531

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 153
Total Number 156
Disease Relevance 82.84
Pain Relevance 42.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
macrophages 7
monocytes 4
colons 4
brain 2
bone marrow 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 677 100.00 Very High Very High Very High
rheumatoid arthritis 243 100.00 Very High Very High Very High
chemokine 234 100.00 Very High Very High Very High
Inflammatory response 154 100.00 Very High Very High Very High
COX2 62 100.00 Very High Very High Very High
Osteoarthritis 40 100.00 Very High Very High Very High
Opioid 22 100.00 Very High Very High Very High
Morphine 106 99.92 Very High Very High Very High
opiate 22 99.92 Very High Very High Very High
excitatory amino acid 1 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1391 100.00 Very High Very High Very High
Cancer 599 100.00 Very High Very High Very High
Death 269 100.00 Very High Very High Very High
Rheumatoid Arthritis 244 100.00 Very High Very High Very High
Necrosis 95 100.00 Very High Very High Very High
Myocardial Infarction 48 100.00 Very High Very High Very High
Osteoarthritis 37 100.00 Very High Very High Very High
Apoptosis 562 99.92 Very High Very High Very High
Obesity 151 99.84 Very High Very High Very High
Nociception 70 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While normal NF-kappaB activation is necessary for cell survival and immunity, deregulated NF-kappaB expression is a characteristic phenomenon in cancer development, as well as in several inflammatory diseases.
Gene_expression (expression) of NF-kappaB associated with inflammation, cancer and disease
1) Confidence 0.75 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17919455 Disease Relevance 0.39 Pain Relevance 0.10
We hypothesized that inhibiting nuclear factor-kappa B gene expression with nuclear factor-kappa B decoy may suppress inflammatory pain.
Gene_expression (expression) of nuclear factor-kappa B
2) Confidence 0.74 Published 2006 Journal Spine Section Body Doc Link 17139220 Disease Relevance 0.08 Pain Relevance 0
This was associated with decreased phosphorylation of NF-kappaB inhibitor protein, IkappaBalpha, and decreased expression of several NFkappaB-regulated genes.
Gene_expression (expression) of NF-kappaB
3) Confidence 0.70 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.87 Pain Relevance 0.29
This was accompanied by lower activity of nuclear factor kappa B (NF-kappaB), higher expression of transforming growth factor beta in the colons and lower expression of inducible nitric oxide synthase in the tumors of fat-1 animals.
Gene_expression (expression) of nuclear factor kappa B in colons associated with cancer
4) Confidence 0.68 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17634405 Disease Relevance 1.17 Pain Relevance 0.23
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.
Neg (lacking) Gene_expression (lacking) of p50 subunit associated with nociception, inflammation and cox2
5) Confidence 0.68 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17217946 Disease Relevance 1.07 Pain Relevance 1.01
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.
Neg (lacking) Gene_expression (lacking) of NF-kappaB associated with nociception, inflammation and cox2
6) Confidence 0.68 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17217946 Disease Relevance 1.12 Pain Relevance 1.06
Therefore, we investigated left ventricular remodeling in mice with a targeted deletion of the NF-kappaB subunit p50/NF-kappaB1 after myocardial infarction.
Gene_expression (deletion) of p50 associated with myocardial infarction and ventricular remodeling
7) Confidence 0.68 Published 2006 Journal FASEB J. Section Abstract Doc Link 16837548 Disease Relevance 0.99 Pain Relevance 0.28
Therefore, we investigated left ventricular remodeling in mice with a targeted deletion of the NF-kappaB subunit p50/NF-kappaB1 after myocardial infarction.
Gene_expression (deletion) of NF-kappaB associated with myocardial infarction and ventricular remodeling
8) Confidence 0.68 Published 2006 Journal FASEB J. Section Abstract Doc Link 16837548 Disease Relevance 0.99 Pain Relevance 0.28
As such, NF-kappaB functions as a key regulator of cardiac gene expression programs downstream of multiple signal transduction cascades in a variety of physiological and pathophysiological states.
Gene_expression (expression) of NF-kappaB
9) Confidence 0.66 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 0.49 Pain Relevance 0.17
Therefore, we investigated left ventricular remodeling in mice with a targeted deletion of the NF-kappaB subunit p50/NF-kappaB1 after myocardial infarction.
Gene_expression (deletion) of NF-kappaB1 associated with myocardial infarction and ventricular remodeling
10) Confidence 0.65 Published 2006 Journal FASEB J. Section Abstract Doc Link 16837548 Disease Relevance 0.99 Pain Relevance 0.28
B1 (p50) protein, the quantity of which can be expressed as MFI.
Gene_expression (expressed) of p50
11) Confidence 0.64 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.74 Pain Relevance 0.46
NF-kB was found predominantly in parenchymal and endothelial cells and was composed primarily of relatively inactive p50 homodimer subunits in control liver.
Gene_expression (found) of NF-kB in liver
12) Confidence 0.63 Published 1995-1996 Journal J. Inflamm. Section Abstract Doc Link 9117441 Disease Relevance 0.49 Pain Relevance 0.59
B-p65 and -p50 expression after exposure in Ppar?
Gene_expression (expression) of p50
13) Confidence 0.62 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.43 Pain Relevance 0.08
In this work, we studied transgenic glial fibrillary acidic protein-IkappaBalpha-dn mice that selectively inactivate the classical nuclear factor kappaB pathway by overexpressing the inhibitory protein of kappaBalpha in astrocytes, under the control of glial fibrillary acidic protein promoter.
Gene_expression (overexpressing) of nuclear factor kappaB in astrocytes associated with targeted disruption
14) Confidence 0.59 Published 2007 Journal Neuroreport Section Abstract Doc Link 17426605 Disease Relevance 0.54 Pain Relevance 0.20
This was accompanied by lower activity of nuclear factor kappa B (NF-kappaB), higher expression of transforming growth factor beta in the colons and lower expression of inducible nitric oxide synthase in the tumors of fat-1 animals.
Gene_expression (expression) of NF-kappaB in colons associated with cancer
15) Confidence 0.59 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17634405 Disease Relevance 1.17 Pain Relevance 0.23
This was accompanied by lower activity of nuclear factor kappa B (NF-kappaB), higher expression of transforming growth factor beta in the colons and lower expression of inducible nitric oxide synthase in the tumors of fat-1 animals.
Gene_expression (expression) of NF-kappaB in colons associated with cancer
16) Confidence 0.59 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17634405 Disease Relevance 1.16 Pain Relevance 0.23
This was accompanied by lower activity of nuclear factor kappa B (NF-kappaB), higher expression of transforming growth factor beta in the colons and lower expression of inducible nitric oxide synthase in the tumors of fat-1 animals.
Gene_expression (expression) of nuclear factor kappa B in colons associated with cancer
17) Confidence 0.59 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17634405 Disease Relevance 1.17 Pain Relevance 0.23
TNF stimulated VEGF-C expression by OCPs and increased nuclear factor-kappa B (NF-?
Gene_expression (expression) of nuclear factor-kappa B
18) Confidence 0.59 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246237 Disease Relevance 0.91 Pain Relevance 0.26
Lignocaine and TTX significantly attenuated the effects of LPS on TLR-4, NF-kappaB, ERK and p38 MAPK expression, but not on JNK.
Gene_expression (expression) of NF-kappaB
19) Confidence 0.58 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.11 Pain Relevance 0.36
We have observed no significant decreases in gene expression during innate immune responses in p50-deficient mice.
Gene_expression (expression) of p50
20) Confidence 0.58 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.15 Pain Relevance 0.10

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