INT5254

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 10.42
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
cardiomyocytes 2
head 2
blood 1
neurons 1
brain 1
Pla2g2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 8 100.00 Very High Very High Very High
opiate 3 100.00 Very High Very High Very High
anesthesia 20 99.82 Very High Very High Very High
halothane 50 99.70 Very High Very High Very High
Dopamine 5 98.48 Very High Very High Very High
Inflammatory stimuli 2 98.48 Very High Very High Very High
dexamethasone 43 98.12 Very High Very High Very High
Central grey 2 97.80 Very High Very High Very High
Multiple sclerosis 42 97.36 Very High Very High Very High
Hyperalgesia 7 94.00 High High
Disease Link Frequency Relevance Heat
Obstructive Jaundice 37 99.96 Very High Very High Very High
Pancreatitis 79 99.82 Very High Very High Very High
Proteinuria 2 99.12 Very High Very High Very High
Autoimmune Disease 12 98.68 Very High Very High Very High
Death 4 98.50 Very High Very High Very High
INFLAMMATION 88 98.48 Very High Very High Very High
Injury 26 98.30 Very High Very High Very High
Urological Neuroanatomy 6 97.80 Very High Very High Very High
Apoptosis 60 97.68 Very High Very High Very High
Multiple Sclerosis 112 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Polychlorinated biphenyls (PCBs) are a group of persistent environmental toxicants previously associated with decreased gestation length that are capable of activating PLA2.
Positive_regulation (activating) of PLA2
1) Confidence 0.68 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16436530 Disease Relevance 0 Pain Relevance 0
The increased expression of the 50-kDa PLA2G6 was associated with a gestational age-related increase in endometrial calcium-independent PLA2 activity that was sensitive to inhibition by bromoenol lactone (P < 0.05).
Positive_regulation (increase) of PLA2
2) Confidence 0.68 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16436530 Disease Relevance 0.20 Pain Relevance 0.20
These studies gave the following results: (1) Rat retinal sonicates contained PLA2 activity of 4.2+/-0.8 pmol PE hydrolyzed/100 ng protein/hr; (2) Halothane (0.25-2.0 mM) increased PLA2 activity by 20 to 150% depending upon concentration; (3) The lower concentration of halothane (0.25 mM) exhibited high activation of PLA2 (150%); (4) High concentrations of halothane (1.0-2.0 mM) caused a low degree of activation of PLA2 (20%); and (5) During phospholipid methylation of retinal membranes with S-adenosyl-L-methionine in the presence of halothane, increased amounts of fatty acid methyl esters (FAME) were formed.
Positive_regulation (increased) of PLA2 associated with halothane
3) Confidence 0.67 Published 1999 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10229494 Disease Relevance 0 Pain Relevance 0.47
This increase in FAME (45%) was possibly due to the hydrolysis of phospholipids by activated PLA2, liberating fatty acids which were methylated.
Spec (possibly) Positive_regulation (activated) of PLA2
4) Confidence 0.67 Published 1999 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10229494 Disease Relevance 0 Pain Relevance 0.55
These observations suggest that the release of retinal transmitters (dopamine, acetylcholine and others) is affected during halothane anesthesia, due to activation of PLA2 and enhanced fusogenic activity of vesicular membranes with plasma membrane and depletion of vesicles.
Positive_regulation (activation) of PLA2 in vesicles associated with anesthesia, dopamine and halothane
5) Confidence 0.67 Published 1999 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10229494 Disease Relevance 0 Pain Relevance 0.41
These studies gave the following results: (1) Rat retinal sonicates contained PLA2 activity of 4.2+/-0.8 pmol PE hydrolyzed/100 ng protein/hr; (2) Halothane (0.25-2.0 mM) increased PLA2 activity by 20 to 150% depending upon concentration; (3) The lower concentration of halothane (0.25 mM) exhibited high activation of PLA2 (150%); (4) High concentrations of halothane (1.0-2.0 mM) caused a low degree of activation of PLA2 (20%); and (5) During phospholipid methylation of retinal membranes with S-adenosyl-L-methionine in the presence of halothane, increased amounts of fatty acid methyl esters (FAME) were formed.
Positive_regulation (activation) of PLA2 associated with halothane
6) Confidence 0.67 Published 1999 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10229494 Disease Relevance 0 Pain Relevance 0.48
These studies gave the following results: (1) Rat retinal sonicates contained PLA2 activity of 4.2+/-0.8 pmol PE hydrolyzed/100 ng protein/hr; (2) Halothane (0.25-2.0 mM) increased PLA2 activity by 20 to 150% depending upon concentration; (3) The lower concentration of halothane (0.25 mM) exhibited high activation of PLA2 (150%); (4) High concentrations of halothane (1.0-2.0 mM) caused a low degree of activation of PLA2 (20%); and (5) During phospholipid methylation of retinal membranes with S-adenosyl-L-methionine in the presence of halothane, increased amounts of fatty acid methyl esters (FAME) were formed.
Positive_regulation (activation) of PLA2 associated with halothane
7) Confidence 0.67 Published 1999 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10229494 Disease Relevance 0 Pain Relevance 0.56
Phospholipase A2 group IIA (PLA2-IIA) and L-type calcium channel (Cacna1c) genes were upregulated in cardiomyocytes and VSMC after stimulation with both purified antibodies from patients and from rabbit [5].
Positive_regulation (upregulated) of Phospholipase A2 group IIA in cardiomyocytes associated with calcium channel
8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.46 Pain Relevance 0.09
We previously described the activation of the eicosanoid metabolic cascade, namely, activation of PLA2 and accumulation of products of both 5-lipoxygenase (5-LO) and cyclo-oxygenase (CO) in the same model of head injury.
Positive_regulation (activation) of PLA2 in head associated with brain injury
9) Confidence 0.50 Published 1992 Journal J Basic Clin Physiol Pharmacol Section Abstract Doc Link 1295574 Disease Relevance 0.66 Pain Relevance 0.08
In order to characterize the in vivo action of phospholipase A2 (PLA2) on opiate receptors and opiate-induced behaviors, the effects of injections of PLA2 into the periaqueductal gray region (PAG) of the rat were assessed on free fatty acid (FFA) release, opiate-binding levels, and morphine-induced behaviors.
Positive_regulation (opiate-induced) of PLA2 associated with urological neuroanatomy, opiate, central grey and morphine
10) Confidence 0.41 Published 1985 Journal Life Sci. Section Abstract Doc Link 3968975 Disease Relevance 0.35 Pain Relevance 0.60
Phospholipase A2 group IIA (PLA2-IIA) and L-type calcium channel (Cacna1c) genes were upregulated in cardiomyocytes and VSMC after stimulation with both purified antibodies from patients and from rabbit [5].
Positive_regulation (upregulated) of PLA2-IIA in cardiomyocytes associated with calcium channel
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.46 Pain Relevance 0.09
We previously described the activation of the eicosanoid metabolic cascade, namely, activation of PLA2 and accumulation of products of both 5-lipoxygenase (5-LO) and cyclo-oxygenase (CO) in the same model of head injury.
Positive_regulation (accumulation) of PLA2 in head associated with brain injury
12) Confidence 0.33 Published 1992 Journal J Basic Clin Physiol Pharmacol Section Abstract Doc Link 1295574 Disease Relevance 0.66 Pain Relevance 0.08
activation of PLA2 are
Positive_regulation (activation) of PLA2
13) Confidence 0.32 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.44 Pain Relevance 0.46
In vitro studies have shown that 5-HT2 receptors can be coupled via G-proteins to phospholipase A2 (PLA2) activation, releasing arachidonic acid from phospholipids.
Positive_regulation (activation) of PLA2
14) Confidence 0.21 Published 2003 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 12928041 Disease Relevance 0 Pain Relevance 0.07
To examine this signaling pathway in brain, we developed an in vivo method to image regional brain PLA2 activation in unanesthetized rats given different types of serotonergic drugs.
Positive_regulation (activation) of PLA2 in brain
15) Confidence 0.20 Published 2003 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 12928041 Disease Relevance 0 Pain Relevance 0.17
In SAP and OJ, PLA2 is activated and massively released into the blood.
Positive_regulation (activated) of PLA2 in blood associated with pancreatitis and obstructive jaundice
16) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.75 Pain Relevance 0.22
Increased generation of oxygen derived free radicals (ODFR) and enhanced activity of phospholipase A2 (PLA2) have been observed in experimental animals following treatment with CsA.
Positive_regulation (enhanced) of PLA2
17) Confidence 0.14 Published 1996 Journal Transplantation Section Abstract Doc Link 8781605 Disease Relevance 0.25 Pain Relevance 0
Compared to the control group, the compression group showed a significant decrease in the number of the HRP-labeled cells and a significant increase in levels of PGE2 and PLA2, in the expression of VEGF protein, and in the number of apoptotic DRG neurons.
Positive_regulation (increase) of PLA2 in neurons associated with apoptosis
18) Confidence 0.08 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19191544 Disease Relevance 0.38 Pain Relevance 0.04
This paper describes work on a proposed hypothesis of cell injury and death in which an hepatotoxin-induced rise in cytosolic free Ca2+ concentration activates phospholipase A2 (PLA2) resulting in the release of arachidonic acid (A.A.) from membrane phospholipids.
Positive_regulation (activates) of PLA2 associated with injury and death
19) Confidence 0.08 Published 1989 Journal Eicosanoids Section Abstract Doc Link 2516744 Disease Relevance 0.42 Pain Relevance 0.22
This paper describes work on a proposed hypothesis of cell injury and death in which an hepatotoxin-induced rise in cytosolic free Ca2+ concentration activates phospholipase A2 (PLA2) resulting in the release of arachidonic acid (A.A.) from membrane phospholipids.
Positive_regulation (activates) of PLA2 associated with injury and death
20) Confidence 0.05 Published 1989 Journal Eicosanoids Section Abstract Doc Link 2516744 Disease Relevance 0.42 Pain Relevance 0.22

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