INT52546

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Context Info
Confidence 0.65
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.09
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR3C2) signal transduction (NR3C2) endoplasmic reticulum (NR3C2)
nucleus (NR3C2) cytoplasm (NR3C2)
Anatomy Link Frequency
PLN 1
NR3C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 97.48 Very High Very High Very High
opiate 5 85.92 High High
antagonist 1 85.36 High High
Lasting pain 1 80.20 Quite High
depression 5 71.76 Quite High
spastic colon 17 50.96 Quite High
Inflammation 67 50.00 Quite Low
Angina 3 50.00 Quite Low
Crohn's disease 14 49.32 Quite Low
cytokine 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Hyperplasia 1 100.00 Very High Very High Very High
Obesity 35 99.36 Very High Very High Very High
Periodontal Pocket 8 92.12 High High
Adenocarcinoma 90 81.92 Quite High
Pain 7 80.20 Quite High
Depression 5 71.76 Quite High
Disease 111 60.96 Quite High
Frailty 18 59.36 Quite High
Enteropathy 2 58.60 Quite High
Colon Cancer 16 54.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine (administered as subcutaneous implants) had profound inhibitory effects on the development of alloreactivity manifested as a suppression of: (1) lymph node hyperplasia, (2) mixed lymphocyte reactivity (MLR) in PLN cells and (3) the number of CD4+ and Thy 1.2 lymphoid subsets.
Gene_expression (suppression) of MLR in PLN associated with hyperplasia and morphine
1) Confidence 0.65 Published 1995 Journal Immunopharmacology Section Abstract Doc Link 7775160 Disease Relevance 0.18 Pain Relevance 1.01
The results of the MLR analysis indicated that BMI (?
Gene_expression (analysis) of MLR associated with obesity
2) Confidence 0.65 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1373609 Disease Relevance 0.32 Pain Relevance 0.04
The MLR was cultured for 5 days and pulsed with 1 ┬ÁCi 3H-Thymidine during the last 12 h of the culture period.
Gene_expression (cultured) of MLR
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.16 Pain Relevance 0
IL-10 (10.94+/-0.56 pg/ml) produced during MLR was lower in patients with US than that of normal patients (16.63+/-3.40 pg/ml), P<0.05.
Gene_expression (produced) of MLR
4) Confidence 0.58 Published 2004 Journal Int. J. Cardiol. Section Body Doc Link 15561347 Disease Relevance 0 Pain Relevance 0
Hence, careful design of novel primers as well as the use of multiple molecular targets (16S rDNA and mcrA) is highly important in recovering a wider range of human methanogens.
Gene_expression (rDNA) of mcrA
5) Confidence 0.28 Published 2010 Journal Archaea Section Body Doc Link PMC3021867 Disease Relevance 0 Pain Relevance 0
First 16S rRNA gene sequences of this putative organism had already been reported earlier (e.g., [27]), however only our combined recovery of both 16S rRNA and mcrA gene sequences with fitting topology of inferred phylogenetic trees from the same individual gave sufficient confidence that humans are colonized by a third Methanobrevibacter phylotype.
Gene_expression (rRNA) of mcrA
6) Confidence 0.24 Published 2010 Journal Archaea Section Body Doc Link PMC3021867 Disease Relevance 0.15 Pain Relevance 0
Restriction fragment length polymorphism (RFLP) using the enzymes Alu I and Mse I of cloned mcrA PCR products and mcrA gene PCR product of Mbb. smithii (DSM 2374) and Mbb. smithii PST was conducted.
Gene_expression (products) of mcrA
7) Confidence 0.13 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.06 Pain Relevance 0
Determination of mcrA gene PCR primer detection limits
Gene_expression (detection) of mcrA
8) Confidence 0.13 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0 Pain Relevance 0
Furthermore, the detection limits of the primers for mcrA gene amplification were calculated and a positive PCR result obtained using the mcrA primer set from spiked samples at cell numbers ?
Gene_expression (primer) of mcrA
9) Confidence 0.13 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.10 Pain Relevance 0.05
Phylogeny of mcrA gene clones
Gene_expression (clones) of mcrA
10) Confidence 0.13 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.05 Pain Relevance 0
Restriction fragment length polymorphism (RFLP) using the enzymes Alu I and Mse I of cloned mcrA PCR products and mcrA gene PCR product of Mbb. smithii (DSM 2374) and Mbb. smithii PST was conducted.
Gene_expression (product) of mcrA
11) Confidence 0.13 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.06 Pain Relevance 0

General Comments

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