INT52586

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Context Info
Confidence 0.01
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm4) plasma membrane (Grm4) intracellular (Grm4)
signal transducer activity (Grm4)
Anatomy Link Frequency
synapses 1
Grm4 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 5 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
antinociception 4 99.72 Very High Very High Very High
tetrodotoxin 1 98.96 Very High Very High Very High
Pyramidal cell 3 83.88 Quite High
Hippocampus 3 76.52 Quite High
MU agonist 2 75.00 Quite High
agonist 1 74.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RATIONALE: Recent experimental data suggest that metabotropic glutamate receptor (mGluR) antagonists with selectivity for mGluR1 and mGluR2/3 enhance morphine-induced antinociception.
Positive_regulation (enhance) of mGluR associated with antinociception, antagonist, glutamate receptor and morphine
1) Confidence 0.01 Published 2008 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 18392754 Disease Relevance 0 Pain Relevance 0.52
OBJECTIVES: The present study addressed the hypothesis that mGluR antagonists enhance opioid antinociception by increasing opioid efficacy.
Positive_regulation (enhance) of mGluR
2) Confidence 0.01 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18392754 Disease Relevance 0 Pain Relevance 0
In contrast, activation of metabotropic glutamate receptors (mGluRs) by transmitter liberated during repetitive activation of these synapses produces an excitation with a much slower time course.
Positive_regulation (activation) of mGluRs in synapses associated with glutamate receptor
3) Confidence 0.00 Published 1995 Journal J. Neurobiol. Section Abstract Doc Link 7775971 Disease Relevance 0 Pain Relevance 0.41

General Comments

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