INT52589

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 3.84
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN5A)
Anatomy Link Frequency
HeLa 4
embryo 2
follicles 2
brain 2
mere 2
SCN5A (Homo sapiens)
SCN5A - R43Q (1) SCN5A - R878C (1)
Pain Link Frequency Relevance Heat
medulla 1 98.16 Very High Very High Very High
endometriosis 3 97.50 Very High Very High Very High
hyperexcitability 5 96.72 Very High Very High Very High
abdominal pain 4 94.64 High High
sodium channel 17 92.40 High High
Paroxysmal extreme pain disorder 42 90.80 High High
Nav1.7 30 90.32 High High
depression 28 88.12 High High
tetrodotoxin 4 82.12 Quite High
antagonist 5 79.56 Quite High
Disease Link Frequency Relevance Heat
Syndrome 136 100.00 Very High Very High Very High
Endometriosis 3 99.64 Very High Very High Very High
Adhesions 1 98.06 Very High Very High Very High
Reprotox - General 3 22 97.08 Very High Very High Very High
Hypoglycemia 31 96.92 Very High Very High Very High
Shock 7 96.32 Very High Very High Very High
Hypopituitarism 1 95.92 Very High Very High Very High
Abdominal Pain 4 94.64 High High
Heart Rate Under Development 49 93.44 High High
Somatoform Disorder 44 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using RT-PCR analysis, we detected hH1/SCN5A mRNA in both fetal and adult human brain.
Positive_regulation (detected) of Gene_expression (detected) of hH1 in brain
1) Confidence 0.49 Published 2000 Journal Brain Res. Section Abstract Doc Link 11134623 Disease Relevance 0.17 Pain Relevance 0.26
In tsA201 cells transfected with SCN5A/R43Q, although the baseline kinetics of the Na current were similar to wild type, lidocaine caused a unique hyperpolarizing shift of the activation and increased the availability of Na currents at resting voltages.
Positive_regulation (transfected) of Gene_expression (transfected) of R43Q (R43Q)
2) Confidence 0.49 Published 2008 Journal Heart Rhythm Section Body Doc Link 18848812 Disease Relevance 0.21 Pain Relevance 0
A recent multicenter study went as far as indicating that in their protocol the mere presence of a SCN5A mutation, even in a totally asymptomatic individual, is sufficient for immediate ICD implant; the authors added that none of their LQT3 patients has received shocks so far [71].
Positive_regulation (sufficient) of Gene_expression (mutation) of SCN5A in mere associated with shock
3) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.96 Pain Relevance 0.03
A 31-year-old female with four years of infertility due to endometriosis and severe pelvic adhesions underwent transvaginal ultrasound-guided aspiration of an ovarian endometrioma before ovulation induction for in vitro fertilization (IVF) and embryo transfer.
Positive_regulation (induction) of Gene_expression (transfer) of IVF in embryo associated with endometriosis, reprotox - general 3 and adhesions
4) Confidence 0.39 Published 1998 Journal Zhonghua Yi Xue Za Zhi (Taipei) Section Abstract Doc Link 9830238 Disease Relevance 0.72 Pain Relevance 0.14
On the other hand, in couples with idiopathic subfertility directly undergoing IVF instead of IUI treatment, TFF does not necessarily persist during subsequent IVF cycles [8].
Positive_regulation (undergoing) of Gene_expression (undergoing) of IVF
5) Confidence 0.38 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2632644 Disease Relevance 0 Pain Relevance 0
Figure 5Aa,Ba confirms successful GFP expression of WT-hNav1.5 (Fig. 5Aa), R878C-hNav1.5 (Fig. 5Ba) and staining of the fluorescent Cy3-conjugated secondary antibody (Fig. 5A,B, panel b) respectively.
Positive_regulation (successful) of Gene_expression (expression) of R878C-hNav1.5 (R878C)
6) Confidence 0.36 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0 Pain Relevance 0.17
As one Sunni Muslim IVF patient stated:
Positive_regulation (stated) of Gene_expression (patient) of IVF
7) Confidence 0.31 Published 2006 Journal Cult Med Psychiatry Section Body Doc Link PMC1705533 Disease Relevance 0 Pain Relevance 0
The following IVF/ICSI outcomes were found: a mean duration of GnRH-agonist use prior to IVF/ICSI of 5.35 months (3-26); a mean dosage of FSH used of 208IU (75-450); the mean number of oocytes retrieved was 8.73 (1-30); the mean number of embryos obtained was 3.86 (0-16); the mean number of embryos transferred was 1.6; a mean fertilization rate of 43.6%; a mean implantation rate of 26.3%; a mean miscarriage rate of 24.3%; and a clinical pregnancy rate (fetal heart activity on ultrasound beyond 12 weeks of gestation) of 31.7%.
Positive_regulation (duration) of Gene_expression (use) of IVF/ICSI in oocytes
8) Confidence 0.28 Published 2010 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Body Doc Link 20409633 Disease Relevance 0.14 Pain Relevance 0
However, using the same strategy, we were unsuccessful in obtaining functional, hH1-positive HeLa cell lines, even though hH1 mRNA and protein was produced in these cells.
Positive_regulation (unsuccessful) of Gene_expression (produced) of hH1 in HeLa
9) Confidence 0.26 Published 1995 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 7776389 Disease Relevance 0 Pain Relevance 0.08
In order to develop mammalian cell lines expressing a functional human heart Na+ channel gene (hH1), Chinese hamster ovary (CHO-K1) cells and HeLa cells were transfected with the hH1 gene and the bacterial neomycin (neo) resistance gene.
Positive_regulation (transfected) of Gene_expression (transfected) of hH1 in HeLa
10) Confidence 0.26 Published 1995 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 7776389 Disease Relevance 0 Pain Relevance 0
For example, in this study three out of four couples were undergoing their first IVF and fewer than one in ten was undergoing their third IVF.
Positive_regulation (undergoing) of Gene_expression (undergoing) of IVF
11) Confidence 0.16 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2517152 Disease Relevance 0.46 Pain Relevance 0.12
It has been reported that high LH levels in the follicular phase of the IVF cycle could have a detrimental effect on the outcome of IVF104,105 but a minimum threshold serum concentration of LH is required for optimum folliculogenesis.38 According to Loumaye and colleagues, the effect of LH on the growing cohort of follicles demonstrates a ceiling effect and exceeding a certain threshold can compromise follicular development.38
Positive_regulation (have) of Gene_expression (cycle) of IVF in follicles
12) Confidence 0.12 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0 Pain Relevance 0.11
Subsitution of the second methionine (Mb) with a positively charged residue (M1652R) in Nav1.5 causes LQT-3 syndrome [44].
Positive_regulation (causes) of Gene_expression (syndrome) of LQT-3 associated with syndrome
13) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.52 Pain Relevance 0.42
The guidelines specifically recommend DPP-4 inhibitors as monotherapy for patients with HbA1c levels between 6.5% and 7.5%, as part of 2-drug combination therapy with metformin in patients with HbA1c levels between 7.6% and 9.0%, and as part of triple combination therapy (eg, with metformin and a TZD) for patients with HbA1c > 9.0%.1 The guidelines also note that these agents have low risk for hypoglycemia and no long-term toxicities to date.1
Positive_regulation (with) of Gene_expression (levels) of HbA1c associated with hypoglycemia
14) Confidence 0.03 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963920 Disease Relevance 0.33 Pain Relevance 0
The guidelines specifically recommend DPP-4 inhibitors as monotherapy for patients with HbA1c levels between 6.5% and 7.5%, as part of 2-drug combination therapy with metformin in patients with HbA1c levels between 7.6% and 9.0%, and as part of triple combination therapy (eg, with metformin and a TZD) for patients with HbA1c > 9.0%.1 The guidelines also note that these agents have low risk for hypoglycemia and no long-term toxicities to date.1
Positive_regulation (with) of Gene_expression (levels) of HbA1c associated with hypoglycemia
15) Confidence 0.03 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963920 Disease Relevance 0.32 Pain Relevance 0

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