INT52590

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Context Info
Confidence 0.55
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN5A)
Anatomy Link Frequency
brain 1
SCN5A (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 1 98.16 Very High Very High Very High
sodium channel 10 95.76 Very High Very High Very High
tetrodotoxin 6 82.24 Quite High
beta blocker 3 57.60 Quite High
potassium channel 3 53.80 Quite High
Calcium channel 3 20.08 Low Low
Action potential 4 8.24 Low Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 1 89.52 High High
Disease 17 89.20 High High
Syndrome 37 87.24 High High
Myocardial Infarction 7 84.00 Quite High
Congenital Anomalies 2 79.88 Quite High
Breast Cancer 4 75.00 Quite High
Malignant Neoplastic Disease 3 61.12 Quite High
Heart Rate Under Development 7 40.64 Quite Low
Arrhythmias 2 Under Development 5 38.24 Quite Low
Adhesions 2 7.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with the siRNA rapidly reduced (by approximately 90%) the level of nNav1.5 (but not adult Nav1.5) mRNA, but the protein reduction was much smaller (approximately 30%), even after 13 days.
Transcription (level) of Nav1.5
1) Confidence 0.55 Published 2007 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 16838113 Disease Relevance 0.22 Pain Relevance 0.29
Using RT-PCR analysis, we detected hH1/SCN5A mRNA in both fetal and adult human brain.
Transcription (detected) of hH1 in brain
2) Confidence 0.52 Published 2000 Journal Brain Res. Section Abstract Doc Link 11134623 Disease Relevance 0.17 Pain Relevance 0.26
At variance with KvLQT1 and HERG proteins mutation, a single SCN5A transcript forms a fully functional channel protein (called Nav1.5).
Transcription (transcript) of SCN5A
3) Confidence 0.49 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.51 Pain Relevance 0.10
Therefore, we developed a stepwise strategy for isolation of cell lines expressing functional hH1 Na+ channels: G418-resistant colonies were sequentially analysed for (1) chromosomal integration of hH1 DNA by PCR, (2) specific hH1 mRNA expression by RT-PCR, (3) hH1 protein production by immunoprecipitation with hH1-specific antisera, and (4) hH1 Na+ channel function by patch-clamp analysis.
Transcription (expression) of hH1
4) Confidence 0.28 Published 1995 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 7776389 Disease Relevance 0 Pain Relevance 0

General Comments

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