INT52591

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 78
Total Number 88
Disease Relevance 13.95
Pain Relevance 15.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
myometrium 9
brain 4
neural 2
sensory neurons 2
neuronal 2
KCNMA1 (Homo sapiens)
KCNMA1 - D1790G (1)
Pain Link Frequency Relevance Heat
potassium channel 575 100.00 Very High Very High Very High
tetrodotoxin 195 100.00 Very High Very High Very High
sodium channel 78 100.00 Very High Very High Very High
bradykinin 49 100.00 Very High Very High Very High
Calcium channel 24 100.00 Very High Very High Very High
dorsal root ganglion 62 99.84 Very High Very High Very High
nociceptor 11 99.10 Very High Very High Very High
qutenza 14 98.64 Very High Very High Very High
nav1.8 5 98.44 Very High Very High Very High
ASIC 2 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 95 99.92 Very High Very High Very High
Nociception 24 99.84 Very High Very High Very High
Targeted Disruption 37 99.82 Very High Very High Very High
Pre-term Labor 96 99.76 Very High Very High Very High
Ganglion Cysts 67 99.36 Very High Very High Very High
Breast Cancer 14 98.92 Very High Very High Very High
Coagulation Disorder 4 98.76 Very High Very High Very High
Syndrome 12 98.24 Very High Very High Very High
INFLAMMATION 33 98.16 Very High Very High Very High
Endotoxemia 4 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KCNMA1 expression was found to be higher in breast tumors and brain metastases [50].
Gene_expression (expression) of KCNMA1 in brain associated with breast cancer and metastasis
1) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.15 Pain Relevance 0
Using the RNAi technology, we have investigated the response of PC3 and LNCaP cell lines to selenium treatment in the presence of low expression levels of KCNMA1, the most significant candidate gene discovered in the present study.
Gene_expression (expression) of KCNMA1
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.16 Pain Relevance 0
We utilized the RNAi methodology to investigate the selenium response under reduced expression levels of KCNMA1 (the most significant candidate) in PC3 as well as in LNCaP cell lines.
Gene_expression (expression) of KCNMA1
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.08 Pain Relevance 0
subunit mRNA expression, the increased proportion of Maxi-K ?
Gene_expression (expression) of Maxi-K
4) Confidence 0.68 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
subunits expressing this variant was very low, accounting for only ~1% of Maxi-K channels expressed in the three tissues sets.
Gene_expression (expressed) of Maxi-K
5) Confidence 0.68 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Little is currently known about the physiological effects of expression of this variant of the Maxi-K channel.
Gene_expression (expression) of Maxi-K channel
6) Confidence 0.68 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
A reduction in expression of the Maxi-K ?
Gene_expression (expression) of Maxi-K
7) Confidence 0.68 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Our results suggested that the four SNPs identified in this study were located within LD blocks that were part of the KCNMA1, SGCD, AKAP6, and PRKG1 genes and that did not extend beyond the gene boundaries.
Gene_expression (part) of KCNMA1
8) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0
The knock-down of KCNMA1 by K6 and K7 siRNA probes displayed similar trend of increased sensitivity to selenium treatment of PC3 cell lines.
Gene_expression (probes) of KCNMA1 associated with targeted disruption
9) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.10 Pain Relevance 0
5 dilutions (5 fold dilutions) were set up for beta actin control and KCNMA1 target in separate duplicate wells.
Gene_expression (target) of KCNMA1
10) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0
The treatment with selenium caused a reduction in the expression of KCNMA1 in PC3 cell lines in comparison to scram cells (untreated with siRNA) (Table 3).
Gene_expression (expression) of KCNMA1
11) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.05 Pain Relevance 0
Pharmacological inhibition of Maxi-K channels, by the specific channel blocker iberiotoxin, increases contractile activity in human uterine tissue [5], whereas compounds that promote Maxi-K channel opening, such as NS1619, have a potent relaxant effect on pregnant human myometrium [6].
Gene_expression (channels) of Maxi-K in myometrium
12) Confidence 0.59 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0.06 Pain Relevance 0
The proportion of Maxi-K ?
Gene_expression (proportion) of Maxi-K
13) Confidence 0.59 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
In contrast, while there was no significant change in the mRNA levels of the 132 bp spliced exon in absolute terms between the three tissue sets, there was a significant increase (~1.7 fold) in the proportion of Maxi-K ?
Gene_expression (proportion) of Maxi-K
14) Confidence 0.59 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
RT-PCR analysis of the Maxi-K ?
Gene_expression (analysis) of Maxi-K
15) Confidence 0.59 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
The 3' conserved region of the Maxi-K ?
Gene_expression (region) of Maxi-K
16) Confidence 0.59 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
The objectives of this study were to investigate mRNA expression of the Maxi-K alpha subunit, and that of its splice variants, in human non-pregnant and pregnant myometrium, prior to and after labour onset, to determine whether altered expression of these splice variants is associated with decreased calcium sensitivity observed at labour onset.


Spec (investigate) Gene_expression (expression) of Maxi-K in myometrium
17) Confidence 0.53 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.09 Pain Relevance 0.09
RNA was extracted from all biopsies and quantitative real-time RT-PCR was used to investigate for possible differential expression of the Maxi-K alpha subunit, and that of its splice variants, between these functionally-distinct myometrial tissue sets.


Spec (possible) Gene_expression (expression) of Maxi-K
18) Confidence 0.53 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.07 Pain Relevance 0.07
However, the regulatory mechanism(s) governing the expression of Maxi-K channels with decreased calcium sensitivity at parturition are unclear.
Gene_expression (expression) of Maxi-K
19) Confidence 0.53 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.10 Pain Relevance 0.10
Quantitative real-time PCR indicated a decrease in the expression of the Maxi-K alpha subunit with labour onset.
Gene_expression (expression) of Maxi-K
20) Confidence 0.53 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.05 Pain Relevance 0.05

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