INT5261

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.17
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AGL) transferase activity, transferring glycosyl groups (AGL) carbohydrate metabolic process (AGL)
cytoplasm (AGL) cytosol (AGL) hydrolase activity, acting on glycosyl bonds (AGL)
Anatomy Link Frequency
neuronal 2
liver 2
muscle 2
Brain 1
AGL (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 1 99.78 Very High Very High Very High
anesthesia 6 93.08 High High
Pain 8 88.00 High High
positron emission tomography 2 81.68 Quite High
abdominal pain 1 54.56 Quite High
nud 1 50.72 Quite High
fibrosis 1 25.00 Low Low
Inflammation 17 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 15 98.88 Very High Very High Very High
Congenital Anomalies 14 98.82 Very High Very High Very High
Hepatomegaly 8 98.46 Very High Very High Very High
Diabetes Mellitus 35 98.18 Very High Very High Very High
Cancer 129 97.28 Very High Very High Very High
Stress 13 96.68 Very High Very High Very High
Hyperglycemia 54 95.20 Very High Very High Very High
Pain 4 88.00 High High
Disease 36 79.20 Quite High
Glycogen Storage Disease 20 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The energetics of glycogen metabolism suggest that glial glycogen is mobilized to meet increased metabolic demands of glia rather than to serve as a substrate for neuronal activity.
Localization (mobilized) of glycogen in neuronal
1) Confidence 0.36 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1295664 Disease Relevance 0 Pain Relevance 0.09
The energetics of glycogen metabolism suggest that glial glycogen is mobilized to meet increased metabolic demands of glia rather than to serve as a substrate for neuronal activity.
Localization (mobilized) of glycogen in neuronal
2) Confidence 0.36 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1295664 Disease Relevance 0 Pain Relevance 0.09
Brain glycogen is localized almost exclusively to glia, where it undergoes continuous utilization and resynthesis.
Localization (localized) of glycogen in Brain
3) Confidence 0.36 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1295664 Disease Relevance 0 Pain Relevance 0.08
Whereas liver glycogen can be made globally available to metabolically active cells (including working myocytes) throughout the body via glycogenolysis and release of the resulting glycogen-derived glucose into the bloodstream, muscle glycogen can be used only by the cell in which it has been synthesized and stored.
Localization (release) of glycogen in muscle
4) Confidence 0.30 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0 Pain Relevance 0
Genotype-phenotype correlation is poor, modifying genes as angiotensin converting enzyme or actin 3 genes may play a role [53–55].As a consequence of myophosphorylase deficiency, the contracting muscle is not able to mobilize adequate amounts of muscle glycogen during the initial anaerobic phase of exercise.
Localization (mobilize) of glycogen in muscle
5) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.36 Pain Relevance 0
As previously suggested, such a glycogen-dependent regulation of gene expression may take place through glycogen regulatory enzymes such as protein phosphatase 1 (PP1) and glycogen synthase kinase 3 (GSK3), which are bound to the glycogen scaffold, but released when the glycogen content decreases (15).
Localization (released) of glycogen
6) Confidence 0.02 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
As previously suggested, such a glycogen-dependent regulation of gene expression may take place through glycogen regulatory enzymes such as protein phosphatase 1 (PP1) and glycogen synthase kinase 3 (GSK3), which are bound to the glycogen scaffold, but released when the glycogen content decreases (15).
Localization (released) of glycogen
7) Confidence 0.02 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
In many tumour-bearing animals, there appeared to be host compensation for hypoglycemia at the level of the liver, with increased gluconeogenesis and glycogen mobilization [18].
Localization (mobilization) of glycogen in liver associated with hypoglycemia and cancer
8) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 1.56 Pain Relevance 0.04
In adults with diabetes mellitus, hepatomegaly and abnormalities of liver enzymes occur as a consequence of hepatocellular glycogen accumulation, as has been well described in children.
Localization (accumulation) of glycogen in liver associated with congenital anomalies, diabetes mellitus and hepatomegaly
9) Confidence 0.00 Published 1996 Journal Medicine (Baltimore) Section Abstract Doc Link 8982149 Disease Relevance 0.99 Pain Relevance 0.08
Glucose and lactate also were measured because catecholamines stimulate mobilization of glycogen, which results in glucose and lactate release.
Localization (mobilization) of glycogen associated with catecholamine
10) Confidence 0.00 Published 2005 Journal J. Anim. Sci. Section Abstract Doc Link 15583062 Disease Relevance 0.26 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox