INT52611

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 142
Total Number 142
Disease Relevance 66.31
Pain Relevance 52.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
colon 4
mast cells 3
bone marrow 2
platelet 2
skin 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 593 100.00 Very High Very High Very High
Inflammation 357 100.00 Very High Very High Very High
COX2 141 100.00 Very High Very High Very High
cOX1 27 100.00 Very High Very High Very High
acular 6 100.00 Very High Very High Very High
Analgesic 85 99.92 Very High Very High Very High
Morphine 38 99.90 Very High Very High Very High
Osteoarthritis 70 99.76 Very High Very High Very High
Hyperalgesia 22 99.72 Very High Very High Very High
intrathecal 5 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 550 99.98 Very High Very High Very High
Injury 150 99.90 Very High Very High Very High
Cancer 617 99.88 Very High Very High Very High
Osteoarthritis 70 99.76 Very High Very High Very High
Hyperalgesia 24 99.72 Very High Very High Very High
Lewis Lung Carcinoma 14 99.72 Very High Very High Very High
Fibrosis 9 99.68 Very High Very High Very High
Arthritis 39 99.66 Very High Very High Very High
Targeted Disruption 47 99.60 Very High Very High Very High
Colitis 35 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice.
Negative_regulation (inhibitor) of cyclooxygenase 2 associated with cox2
1) Confidence 0.59 Published 2006 Journal Radiat. Res. Section Title Doc Link 16953674 Disease Relevance 0.28 Pain Relevance 0.19
Meloxicam, a selective inhibitor of cyclooxygenase 2, a nonsteroidal anti-inflammatory drug with an improved side-effects profile in terms of gastrointestinal toxicity, has been found to stimulate hematopoiesis in whole-body gamma-irradiated mice.
Negative_regulation (inhibitor) of cyclooxygenase 2 in body associated with hematological disease, toxicity, inflammation, cinod and cox2
2) Confidence 0.59 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16953674 Disease Relevance 0.29 Pain Relevance 0.19
Furthermore, nimesulid, a cyclooxygenase-2 selective inhibitor, also suppressed colonic aberrant crypt foci/tumors as well as sulindac.
Negative_regulation (inhibitor) of cyclooxygenase-2 associated with aberrant crypt foci and cancer
3) Confidence 0.59 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 12725321 Disease Relevance 1.37 Pain Relevance 0.16
Two selective cyclooxygenase 2 inhibitors exacerbate colitis and premalignant changes in the interleukin 10-/- mouse model of chronic colitis and colitis-associated colon carcinoma.
Negative_regulation (inhibitors) of cyclooxygenase 2 in colon associated with colitis, colon cancer and cox2
4) Confidence 0.59 Published 2003 Journal Inflamm. Bowel Dis. Section Abstract Doc Link 12902846 Disease Relevance 1.78 Pain Relevance 0.14
Selective inhibitors of cyclooxygenase-2 (COX2) have attracted widespread media attention because of evidence of an elevated risk of cardiovascular complications in placebo-controlled trials, resulting in the market withdrawal of some members of this class.
Negative_regulation (inhibitors) of cyclooxygenase-2 associated with cox2 and withdrawal
5) Confidence 0.59 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.13 Pain Relevance 0.29
Rofecoxib, a selective cyclooxygenase 2 inhibitor, does not interfere with the coagulation system and may be a safer NSAID for patients undergoing TKA.
Negative_regulation (inhibitor) of cyclooxygenase 2 associated with cinod and cox2
6) Confidence 0.57 Published 2002 Journal J Arthroplasty Section Abstract Doc Link 11805921 Disease Relevance 0.32 Pain Relevance 0.49
This effect is presumably due to an inhibition of cyclooxygenase 2, an inducible enzyme involved in the synthesis of prostaglandins.
Negative_regulation (inhibition) of cyclooxygenase 2 associated with cox2
7) Confidence 0.57 Published 1998 Journal J Assoc Acad Minor Phys Section Abstract Doc Link 9648425 Disease Relevance 1.03 Pain Relevance 0.46
These include selective inhibitors of cyclooxygenase 2, nitric oxide-releasing NSAIDs, and NSAIDs preassociated with zwitterionic phospholipids.
Negative_regulation (inhibitors) of cyclooxygenase 2 associated with cinod and cox2
8) Confidence 0.56 Published 1997 Journal Gastroenterology Section Abstract Doc Link 9041264 Disease Relevance 0.68 Pain Relevance 0.83
Ibuprofen and meclofenamate inhibit both enzymes with comparable potencies. 6-Methoxy-2-naphthylacetic acid, the active metabolite of Relafen, inhibits murine PGHS-2 preferentially.
Negative_regulation (inhibits) of PGHS-2
9) Confidence 0.56 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.37 Pain Relevance 0.55
Thus, a selective inhibitor of PGHS-2 could be an antiinflammatory agent but without being ulcerogenic.
Negative_regulation (inhibitor) of PGHS-2 associated with inflammation
10) Confidence 0.56 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.36 Pain Relevance 0.46
We have identified NSAIDs that preferentially inhibit murine PGHS-1 or PGHS-2 or inhibit both isozymes equally.
Negative_regulation (inhibit) of PGHS-2 associated with cinod
11) Confidence 0.56 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.49 Pain Relevance 0.72
Ibuprofen and meclofenamate inhibit both enzymes with comparable potencies. 6-Methoxy-2-naphthylacetic acid, the active metabolite of Relafen, inhibits murine PGHS-2 preferentially.
Negative_regulation (inhibits) of PGHS-2
12) Confidence 0.55 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8017762 Disease Relevance 0.18 Pain Relevance 0.52
However, it is now clear that the second isozyme, PGH synthase-2 (PGHS-2), is also inhibited by these compounds.
Negative_regulation (inhibited) of PGHS-2
13) Confidence 0.55 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8017762 Disease Relevance 0.10 Pain Relevance 0.46
However, it is now clear that the second isozyme, PGH synthase-2 (PGHS-2), is also inhibited by these compounds.
Negative_regulation (inhibited) of PGH synthase-2
14) Confidence 0.55 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8017762 Disease Relevance 0.10 Pain Relevance 0.46
The antinociceptive interaction of rofecoxib, a selective cyclooxygenase-2 inhibitor, with aminoguanidine hydrochloride, a selective iNOS inhibitor, was examined in the formalin-induced paw-licking model in mice.
Negative_regulation (inhibitor) of cyclooxygenase-2 in paw associated with antinociceptive
15) Confidence 0.54 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178354 Disease Relevance 0.07 Pain Relevance 0.17
Thus it can be concluded that GTE attenuates LPS-induced central and peripheral hyperalgesia by selective inhibition of cyclooxygenase-2 enzyme.
Negative_regulation (inhibition) of cyclooxygenase-2 enzyme associated with hyperalgesia
16) Confidence 0.51 Published 2005 Journal Phytother Res Section Abstract Doc Link 15799002 Disease Relevance 0.49 Pain Relevance 0.50
DPP exerted analgesic and anti-angiogenic (52% reduction in angiogenesis at 10 mg/kg, i.p.) effects that may be associated with inhibition of cyclooxygenase-2 activity.
Negative_regulation (inhibition) of cyclooxygenase-2 associated with analgesic
17) Confidence 0.49 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15044055 Disease Relevance 0.19 Pain Relevance 0.19
As purified PGHS-2 is now available commercially (Sigma), it may be possible to adapt this assay system to help determine the specificity of novel PGHS-2 inhibitors.
Negative_regulation (inhibitors) of PGHS-2
18) Confidence 0.47 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0 Pain Relevance 0.09
E. splendens (5-100 microg/mL) significantly inhibited PGE2 production by pre-induced cyclooxygenase-2 of lipopolysaccharide-treated RAW 264.7 cells, suggesting that cyclooxygenase-2 inhibition might be one of the cellular mechanisms of anti-inflammation.
Negative_regulation (inhibition) of cyclooxygenase-2 in RAW 264 associated with inflammation
19) Confidence 0.43 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12723937 Disease Relevance 0.87 Pain Relevance 0.44
Animals were given one of the following: saline, ethanol, dimethylsulfoxide (DMSO), morphine, ketoprofen, ketorolac, or DFU (a cyclooxygenase-2 inhibitor).
Negative_regulation (inhibitor) of cyclooxygenase-2 associated with acular and morphine
20) Confidence 0.43 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16368829 Disease Relevance 0.73 Pain Relevance 1.25

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