INT52616

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.95
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
blood 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 12 100.00 Very High Very High Very High
dexamethasone 4 99.98 Very High Very High Very High
cINOD 32 99.96 Very High Very High Very High
cytokine 10 99.56 Very High Very High Very High
Inflammation 17 99.10 Very High Very High Very High
Arthritis 1 93.92 High High
Pain 5 93.24 High High
Analgesic 2 86.32 High High
aspirin 7 83.68 Quite High
COX-2 inhibitor 2 75.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 30 99.68 Very High Very High Very High
Ulcers 7 98.52 Very High Very High Very High
Injury 7 98.44 Very High Very High Very High
Arthritis 2 93.92 High High
Avian Sarcoma 1 93.68 High High
Pain 5 93.24 High High
Peptic Ulcer 2 85.20 High High
Duodenal Ulcer 6 83.92 Quite High
Disease 3 82.72 Quite High
Infection 3 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate a new and potentially important anti-inflammatory property of SK&F 86002, namely the specific suppression of PGHS-2 induction.
Negative_regulation (suppression) of Positive_regulation (induction) of PGHS-2 associated with inflammation
1) Confidence 0.43 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9144511 Disease Relevance 0.15 Pain Relevance 0.21
In vitro enzyme results were supported by a human whole blood assay where etodolac also demonstrated a 10-fold selectivity for inhibition of PGHS-2 mediated TxB2 production.
Negative_regulation (inhibition) of Positive_regulation (mediated) of PGHS-2 in blood
2) Confidence 0.42 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566109 Disease Relevance 0.08 Pain Relevance 0.35
The serious digestive side effects of the selective inhibitors the inducible cyclooxygenase-2 are reduced by 60% as compared to the nonselective non-steroidal anti-inflammatory drugs.
Negative_regulation (reduced) of Positive_regulation (inducible) of cyclooxygenase-2 associated with inflammation and cinod
3) Confidence 0.42 Published 2004 Journal Bull Cancer Section Abstract Doc Link 15899636 Disease Relevance 0.46 Pain Relevance 0.19
The serious digestive side effects of the selective inhibitors the inducible cyclooxygenase-2 are reduced by 60% as compared to the nonselective non-steroidal anti-inflammatory drugs.
Negative_regulation (reduced) of Positive_regulation (inducible) of cyclooxygenase-2 associated with inflammation and cinod
4) Confidence 0.42 Published 2004 Journal Bull Cancer Section Abstract Doc Link 15239340 Disease Relevance 0.46 Pain Relevance 0.19
[Safety of selective inhibitors of inducible cyclooxygenase-2 taken for a long period].
Negative_regulation (inhibitors) of Positive_regulation (inducible) of cyclooxygenase-2 associated with cox2
5) Confidence 0.41 Published 2004 Journal Bull Cancer Section Title Doc Link 15239340 Disease Relevance 0.70 Pain Relevance 0.29
BACKGROUND: Highly selective inhibitors of the inducible cyclooxygenase-2 enzyme (coxibs) have been associated with less gastrotoxicity than nonselective NSAIDs in clinical studies.
Negative_regulation (inhibitors) of Positive_regulation (inducible) of cyclooxygenase-2 enzyme associated with cinod
6) Confidence 0.40 Published 2001 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 11563999 Disease Relevance 0.07 Pain Relevance 0.10
Early indications are that selective inhibitors of the inducible cyclooxygenase-2 enzyme have little or no effect in causing ulcers.
Negative_regulation (inhibitors) of Positive_regulation (inducible) of cyclooxygenase-2 enzyme associated with ulcers
7) Confidence 0.40 Published 2000 Journal Baillieres Best Pract Res Clin Gastroenterol Section Abstract Doc Link 10749097 Disease Relevance 0.87 Pain Relevance 0.48
It is suggested that the selective blockade of inducible cyclooxygenase 2 at the surgical site does not entirely account for the analgesic action occurring in the postoperative period.


Negative_regulation (blockade) of Positive_regulation (inducible) of cyclooxygenase 2
8) Confidence 0.31 Published 2006 Journal Anesthesiology Section Body Doc Link 16394701 Disease Relevance 0 Pain Relevance 0
Dexamethasone inhibits both the basal and induced levels of PGHS-2 mRNA.
Negative_regulation (inhibits) of Positive_regulation (induced) of PGHS-2 mRNA associated with dexamethasone
9) Confidence 0.29 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357977 Disease Relevance 0.16 Pain Relevance 0.20
Most available nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the constitutive cyclooxygenase-1 (COX-1) and the inducible cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin (PG) and thromboxane (TX) biosynthesis.
Negative_regulation (inhibit) of Positive_regulation (inducible) of cyclooxygenase-2 associated with inflammation and cinod
10) Confidence 0.17 Published 1997 Journal Inflamm. Res. Section Abstract Doc Link 9427063 Disease Relevance 0.32 Pain Relevance 0.48
Inducible cyclooxygenase-2 (COX-2), but not constitutive COX-1, can be upregulated in rheumatoid synovial tissue by interleukin-1 beta and phorbol esters and is inhibited by dexamethasone.
Negative_regulation (inhibited) of Positive_regulation (Inducible) of cyclooxygenase-2 associated with dexamethasone
11) Confidence 0.02 Published 1996 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 8628978 Disease Relevance 0.51 Pain Relevance 0.49
Here, we hypothesized that silica-ceramic can reduce the expression and activity of cyclooxygenase 2 (COX2) or cytokines associated with inflammation.
Negative_regulation (reduce) of Positive_regulation (activity) of cyclooxygenase 2 associated with inflammation, cox2 and cytokine
12) Confidence 0.01 Published 2007 Journal Journal of biomedical materials research. Part A Section Abstract Doc Link 17133451 Disease Relevance 0.26 Pain Relevance 0.56
The aims of therapy are aimed at inhibiting the inducible isozyme cyclooxygenase II (COX II) or prostaglandin-H Synthase2 (PGHS2), which contributes to prostanoid synthesis at sites of inflammation.
Negative_regulation (inhibiting) of Positive_regulation (inducible) of isozyme cyclooxygenase II associated with inflammation
13) Confidence 0.00 Published 1995 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 7777800 Disease Relevance 0.90 Pain Relevance 0.59

General Comments

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