INT5262

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.51
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AGL) transferase activity, transferring glycosyl groups (AGL) carbohydrate metabolic process (AGL)
cytoplasm (AGL) cytosol (AGL) hydrolase activity, acting on glycosyl bonds (AGL)
Anatomy Link Frequency
liver 4
hepatocytes 2
covering 1
lipid droplets 1
muscle 1
AGL (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 99.44 Very High Very High Very High
abdominal pain 3 97.36 Very High Very High Very High
Pain 4 86.16 High High
Glutamate 46 77.28 Quite High
Paracetamol 1 75.24 Quite High
nud 2 72.56 Quite High
Dismenorea 3 40.28 Quite Low
fibrosis 2 25.00 Low Low
gABA 14 13.12 Low Low
Neurotransmitter 15 10.64 Low Low
Disease Link Frequency Relevance Heat
Stress 32 99.98 Very High Very High Very High
Glycogen Storage Disease 26 99.56 Very High Very High Very High
Obesity 13 99.52 Very High Very High Very High
Hypoxia 33 99.16 Very High Very High Very High
Disease 11 99.04 Very High Very High Very High
Congenital Anomalies 7 98.82 Very High Very High Very High
Hepatomegaly 13 98.46 Very High Very High Very High
Diabetes Mellitus 16 98.18 Very High Very High Very High
Hepatotoxicity 1 97.56 Very High Very High Very High
Hyperglycemia 4 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mc Ardle's disease is a genetic glycogenosis characterized by the accumulation of glycogen in skeletal muscle secondary to the deficiency of muscle glycogen phosphorylase.
Positive_regulation (accumulation) of glycogen in muscle associated with glycogen storage disease and disease
1) Confidence 0.40 Published 2002 Journal Rev Med Suisse Romande Section Abstract Doc Link 12522938 Disease Relevance 0.94 Pain Relevance 0.09
Liver biopsies in all patients showed only marked accumulation of glycogen in the hepatocytes.
Positive_regulation (accumulation) of glycogen in hepatocytes
2) Confidence 0.28 Published 1989 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 2507626 Disease Relevance 0.50 Pain Relevance 0.10
Free fatty acids increase hepatic glycogen content in obese males.
Positive_regulation (increase) of glycogen associated with obesity
3) Confidence 0.26 Published 2004 Journal Metab. Clin. Exp. Section Title Doc Link 15254882 Disease Relevance 0.50 Pain Relevance 0.08
Conversely, decreased neuronal activity during hibernation and anesthesia is accompanied by a marked increase in brain glycogen content.
Positive_regulation (increase) of glycogen in brain associated with anesthesia
4) Confidence 0.24 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1295664 Disease Relevance 0 Pain Relevance 0.10
The liver typically stores glycogen at a density, , of approximately 270 mmol glycosyl residues per kilogram (), and is capable of storage at a maximum density of approximately 500 mmol glycosyl residues per kilogram ().
Positive_regulation (stores) of glycogen in liver
5) Confidence 0.19 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.06 Pain Relevance 0
Such schedules are designed to induce a ‘glycogen supercompensation’ effect, whereby glycogen depletion and carbohydrate restriction stimulate increased expression of glycogen synthase in the depleted muscle fibers, enhancing their ability to synthesize glycogen during the final, high-carbohydrate-diet phase, permitting muscle fibers to store glycogen in supranormal concentrations.
Positive_regulation (induce) of glycogen in muscle fibers
6) Confidence 0.17 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.05 Pain Relevance 0
Glycogen accumulation in the liver leads to hepatogmegaly and, in some instances, hepatic dysfunction with cirrhosis in the third and fourth decades of life.
Positive_regulation (accumulation) of Glycogen in liver associated with cirrhosis and hepatotoxicity
7) Confidence 0.02 Published 2002 Journal Paediatr Anaesth Section Abstract Doc Link 12358666 Disease Relevance 1.02 Pain Relevance 0
Instead, an increase in glycogen breakdown flux is observed in astrocytes.
Positive_regulation (increase) of glycogen in astrocytes
8) Confidence 0.01 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC2246127 Disease Relevance 0.68 Pain Relevance 0.10
Although it was recently indicated that cold stress induces glycogen and lipid depletion in the liver and the adrenal gland, respectively,6,14 no previous study has investigated the effects of different types of stress on the liver and the adrenal gland.
Positive_regulation (induces) of glycogen in liver associated with stress
9) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845770 Disease Relevance 0.94 Pain Relevance 0
When tissue glycogen stores are depleted, glycogen synthetase activity is transiently increased, leading to an increase of glycogen storage by conversion from carbohydrates [15,16].
Positive_regulation (increased) of glycogen synthetase
10) Confidence 0.01 Published 2006 Journal Nutr J Section Body Doc Link PMC1526446 Disease Relevance 0.12 Pain Relevance 0
In the normal non-pregnant cycle the glycogen accumulations within the glandular epithelial cells begin to disperse around days 23–24, suggesting a decline in secretory activity [39].
Positive_regulation (accumulations) of glycogen in glandular epithelial cells
11) Confidence 0.01 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.35 Pain Relevance 0
Evidence that the glands may act as a source of nutrition for the conceptus is provided by the observation that the syncytiotrophoblast covering the surfaces of villi facing the endometrium contain large accumulations of glycogen that appear as crimson arcs on PAS-staining [7,14].
Positive_regulation (accumulations) of glycogen in covering
12) Confidence 0.01 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0 Pain Relevance 0
They have a tall columnar phenotype, with accumulations of glycogen in the apical cytoplasm and of lipid droplets towards their base.
Positive_regulation (accumulations) of glycogen in lipid droplets
13) Confidence 0.01 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0 Pain Relevance 0
In adults with diabetes mellitus, hepatomegaly and abnormalities of liver enzymes occur as a consequence of hepatocellular glycogen accumulation, as has been well described in children.
Positive_regulation (accumulation) of glycogen in liver associated with congenital anomalies, diabetes mellitus and hepatomegaly
14) Confidence 0.00 Published 1996 Journal Medicine (Baltimore) Section Abstract Doc Link 8982149 Disease Relevance 0.99 Pain Relevance 0.08
The accumulation of excessive amounts of glycogen in the hepatocytes is a function of intermittent episodes of hyperglycemia and hypoglycemia and the use of excessive insulin.
Positive_regulation (accumulation) of glycogen in hepatocytes associated with hypoglycemia and hyperglycemia
15) Confidence 0.00 Published 1996 Journal Medicine (Baltimore) Section Abstract Doc Link 8982149 Disease Relevance 1.36 Pain Relevance 0.11

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