INT52625

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 30
Total Number 34
Disease Relevance 19.12
Pain Relevance 11.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
plasma 5
tears 1
chondrocytes 1
shoulder 1
macrophages 1
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 88 100.00 Very High Very High Very High
anakinra 12 100.00 Very High Very High Very High
cINOD 8 100.00 Very High Very High Very High
aspirin 2 100.00 Very High Very High Very High
cytokine 273 99.98 Very High Very High Very High
rheumatoid arthritis 184 99.84 Very High Very High Very High
Inflammatory response 28 98.84 Very High Very High Very High
Neuritis 35 98.68 Very High Very High Very High
Pain 20 97.96 Very High Very High Very High
chemokine 59 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 284 100.00 Very High Very High Very High
Rheumatoid Arthritis 190 100.00 Very High Very High Very High
Eye Disease 65 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 35 99.64 Very High Very High Very High
Epilepsy 5 99.60 Very High Very High Very High
Disorders Of Creatine Metabolism 5 99.58 Very High Very High Very High
Disease 161 99.44 Very High Very High Very High
Fever 13 99.44 Very High Very High Very High
Obesity 5 98.60 Very High Very High Very High
Diabetes Mellitus 18 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is conceivable that the gender difference in IL-1Ra gene polymorphism found in the current study may affect IL-1 and IL-1ra levels.
Spec (may) Regulation (affect) of IL-1ra
1) Confidence 0.61 Published 2007 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 18052726 Disease Relevance 0.06 Pain Relevance 0.21
Schwann cell-specific regulation of IL-1 and IL-1Ra during EAN: possible relevance for immune regulation at paranodal regions.
Regulation (regulation) of IL-1Ra in Schwann cell
2) Confidence 0.59 Published 2001 Journal J. Neuroimmunol. Section Title Doc Link 11311332 Disease Relevance 0.74 Pain Relevance 0.59
Therefore, we examine SC-specific autoregulation of IL-1alpha, IL-1beta and their natural antagonist IL-1 receptor antagonist (IL-1Ra) during experimental autoimmune neuritis (EAN), a model for the human Guillain-Barre syndrome.
Regulation (autoregulation) of IL-1Ra associated with syndrome, experimental autoimmune neuritis, antagonist and neuritis
3) Confidence 0.59 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311332 Disease Relevance 0.79 Pain Relevance 0.62
Therefore, we examine SC-specific autoregulation of IL-1alpha, IL-1beta and their natural antagonist IL-1 receptor antagonist (IL-1Ra) during experimental autoimmune neuritis (EAN), a model for the human Guillain-Barre syndrome.
Regulation (autoregulation) of antagonist associated with syndrome, experimental autoimmune neuritis, antagonist and neuritis
4) Confidence 0.51 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311332 Disease Relevance 0.79 Pain Relevance 0.62
In addition, the IL1RA VNTR polymorphism influences the plasma IL-1RA levels [13], and IL-1RA modulates IL-1 production [14], although there was no significant association of IL1B -31C>T and IL1RA VNTR with cerebral malaria in Gambia [5].
Regulation (influences) of IL-1RA in plasma associated with cerebral malaria
5) Confidence 0.49 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.64 Pain Relevance 0
VNTR polymorphism in the intron 2 of the IL-1RN gene
Regulation (polymorphism) of IL-1RN
6) Confidence 0.45 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 1.03 Pain Relevance 0.27
This can occur through an influence on circulating or local levels of IL-1ra in humans [22,27].
Regulation (influence) of IL-1ra
7) Confidence 0.45 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.29 Pain Relevance 0.05
We investigated the possible effects of 3 different nonsteroidal antiinflammatory drugs (NSAID; aceclofenac, piroxicam, aspirin) on IL-1Ra and NO production in human articular chondrocytes.
Spec (possible) Regulation (effects) of IL-1Ra in chondrocytes associated with aspirin, inflammation and cinod
8) Confidence 0.42 Published 2001 Journal J. Rheumatol. Section Abstract Doc Link 11764219 Disease Relevance 0.20 Pain Relevance 0.28
In vivo effect of snake phospholipase A2 (crotoxin+cardiotoxin) on serum IL-1alpha, TNF-alpha and IL-1ra level in humans.
Regulation (effect) of IL-1ra
9) Confidence 0.42 Published 2001 Journal Immunol. Lett. Section Title Doc Link 11137138 Disease Relevance 0.34 Pain Relevance 0.33
CONCLUSIONS: The differential regulation of the two forms of IL-1ra mRNAs may play an important role in shoulder pain in rotator cuff diseases, regulating IL-1-induced subacromial synovitis.


Regulation (regulation) of IL-1ra in shoulder
10) Confidence 0.36 Published 2001 Journal Rheumatology (Oxford) Section Body Doc Link 11561109 Disease Relevance 0.13 Pain Relevance 0
The IL-1 receptor antagonist (IL-1 RN) gene is located on chromosome 2, in close proximity to the IL-1A and IL-1B genes.
Regulation (located) of IL-1 RN associated with antagonist
11) Confidence 0.32 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.24 Pain Relevance 0.30
The IL-1 receptor antagonist (IL-1 RN) gene is located on chromosome 2, in close proximity to the IL-1A and IL-1B genes.
Regulation (located) of IL-1 receptor antagonist associated with antagonist
12) Confidence 0.32 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.25 Pain Relevance 0.30
The IL-1ra plasma levels are co-coordinately regulated by both the IL-1RN and IL-1B genes [16,22].
Regulation (regulated) of IL-1ra in plasma
13) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.97 Pain Relevance 0.35
In conclusion, we demonstrated in a cross-sectional study that a polymorphism potentially able to modulate the levels of the IL-1ra cytokine, and indirectly IL-1 (?
Regulation (modulate) of IL-1ra associated with cytokine
14) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.13 Pain Relevance 0.20
The production of IL-1 and IL-1ra is regulated by genotypic and nongenotypic factors and is different between men and women.
Regulation (regulated) of IL-1ra
15) Confidence 0.27 Published 2007 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 18052726 Disease Relevance 0.10 Pain Relevance 0.19
This is illustrated in Figure 3b, which documents graphically the effects of IL-1Ra, BSIP, EDTA, PMSF and leupeptin on collagen type II matrix degradation in the NP and AF.
Regulation (effects) of IL-1Ra
16) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.03
Since IL-1Ra polymorphism is known to affect the levels of both IL-1Ra and IL-1, cytokines associated with modulation of pain sensitivity and morphine analgesia, it is suggested that IL-1Ra genetic polymorphism may contribute to the variation in postoperative morphine consumption.
Regulation (affect) of IL-1Ra associated with pain, analgesia, morphine and cytokine
17) Confidence 0.23 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16777324 Disease Relevance 0.40 Pain Relevance 1.43
Therefore, we examine SC-specific autoregulation of IL-1alpha, IL-1beta and their natural antagonist IL-1 receptor antagonist (IL-1Ra) during experimental autoimmune neuritis (EAN), a model for the human Guillain-Barre syndrome.
Regulation (autoregulation) of antagonist associated with syndrome, experimental autoimmune neuritis, antagonist and neuritis
18) Confidence 0.22 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311332 Disease Relevance 0.78 Pain Relevance 0.61
The plasma level of IL1-RA was influenced by the number of repeats in the IL1RA VNTR [13], and the allele with two repeats (designated as allele 2 in the present study) has been reported to be associated with various diseases.
Regulation (influenced) of IL1-RA in plasma associated with rheumatoid arthritis and disease
19) Confidence 0.22 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.96 Pain Relevance 0
A natural inhibitor of IL-1 exists, IL-1Ra, which would be an ideal molecular target for inhibiting IL-1-mediated effects involved in DIVD and LBP.
Regulation (target) of IL-1Ra in DIVD associated with backache
20) Confidence 0.20 Published 2006 Journal Int J Exp Pathol Section Abstract Doc Link 16436110 Disease Relevance 0.53 Pain Relevance 0.45

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