INT52633

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.99
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 1
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 16 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
Antinociceptive 8 99.98 Very High Very High Very High
Analgesic 2 99.68 Very High Very High Very High
Morphine 12 98.48 Very High Very High Very High
antagonist 7 96.32 Very High Very High Very High
tail-flick 2 88.28 High High
tolerance 8 84.76 Quite High
Dopamine 3 68.88 Quite High
Kappa opioid receptor 1 55.96 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 99.84 Very High Very High Very High
Stress 64 99.16 Very High Very High Very High
Stress Incontinence 35 99.04 Very High Very High Very High
Disease 23 96.16 Very High Very High Very High
Sprains And Strains 7 93.76 High High
Toxicity 3 90.64 High High
Cadasil 2 89.12 High High
Leukoencephalopathies 2 88.76 High High
Death 21 86.52 High High
Scrapie 23 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different from this previous report, we propose that the Notch1 protein level is decreased under the oxidative stress condition but that periostin physically associates with the Notch1 precursor, and then maintains Notch1 protein expression and subsequent signaling under this stress condition.
Negative_regulation (decreased) of Notch1 protein associated with stress
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.99 Pain Relevance 0.10
We next investigated whether the reduction in mature Notch1 level would affect survival of PDL cells in vivo.
Spec (whether) Negative_regulation (reduction) of Notch1
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.69 Pain Relevance 0
When TAN-67 (5-20 mg/kg, s.c.) was coadministered with morphine (1 mg/kg, s.c.), the morphine-induced place preference was enhanced dose dependently, and this effect of TAN-67 was suppressed by the pretreatment with naltrindole (1 mg/kg, s.c.), a nonselective delta opioid receptor antagonist, 7-benzylidenenaltrexone (0.05 and 0.5 mg/kg, s.c.), a selective delta 1 opioid receptor antagonist, and naltriben (0.05 and 0.5 mg/kg, s.c.), a selective delta 2 opioid receptor antagonist.
Negative_regulation (suppressed) of TAN-67 associated with antagonist, opioid receptor and morphine
3) Confidence 0.31 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8858991 Disease Relevance 0 Pain Relevance 1.04
Antinociceptive effects of the selective non-peptidic delta-opioid receptor agonist TAN-67 in diabetic mice.
Negative_regulation (effects) of TAN-67 associated with diabetes mellitus, agonist, opioid receptor and antinociceptive
4) Confidence 0.30 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7781682 Disease Relevance 0.63 Pain Relevance 0.67
This is a particularly potent Notch-1 inhibitor.
Negative_regulation (inhibitor) of Notch-1 in Notch
5) Confidence 0.12 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox