INT52651

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 136
Total Number 140
Disease Relevance 40.82
Pain Relevance 99.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neurons 18
spinal 5
brain 4
dorsal horn 4
amygdala 3
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1067 100.00 Very High Very High Very High
Kinase C 447 100.00 Very High Very High Very High
Neurotransmitter 72 100.00 Very High Very High Very High
adenocard 50 100.00 Very High Very High Very High
Cannabinoid 7 100.00 Very High Very High Very High
dopamine receptor 4 100.00 Very High Very High Very High
Dorsal horn 84 99.98 Very High Very High Very High
Dorsal horn neuron 84 99.98 Very High Very High Very High
central sensitization 230 99.96 Very High Very High Very High
withdrawal 532 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 13 99.90 Very High Very High Very High
Pain 2135 99.82 Very High Very High Very High
Adenovirus Infection 7 99.68 Very High Very High Very High
Neuropathic Pain 207 99.56 Very High Very High Very High
Opiate Addiction 8 99.56 Very High Very High Very High
Hyperalgesia 94 99.50 Very High Very High Very High
Ganglion Cysts 239 99.48 Very High Very High Very High
Reprotox - General 1 58 99.42 Very High Very High Very High
Arthritis 1474 99.32 Very High Very High Very High
Depression 102 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If added before cAMP, NSAIDs impaired PKA activation by the cyclic nucleotide; however, if PKA was first activated by cAMP, NSAIDs were ineffective.
Positive_regulation (activation) of PKA associated with cinod
1) Confidence 0.67 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.49 Pain Relevance 1.01
Although other voltage-gated Na+ currents are modulated by the activation of protein kinase C (PKC), protein kinase A (PKA), or both, the second messenger pathways involved in the modulation of TTX-R INa are still being defined.
Positive_regulation (activation) of PKA associated with kinase c
2) Confidence 0.57 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.10 Pain Relevance 0.34
Activation of either PKC or PKA increased TTX-R INa.
Positive_regulation (Activation) of PKA associated with kinase c
3) Confidence 0.57 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.09 Pain Relevance 0.40
PKA activation also produced a leftward shift in the conductance-voltage relationship of TTX-R INa and an increase in the rates of current activation, deactivation, and inactivation.
Positive_regulation (activation) of PKA
4) Confidence 0.57 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.08 Pain Relevance 0.43
It is concluded that stimulation of PKA potentiates spontaneous GABA release in immature hippocampal neurons.
Positive_regulation (stimulation) of PKA in neurons associated with gaba
5) Confidence 0.54 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7783966 Disease Relevance 0 Pain Relevance 0.26
Results suggest that activation of the cAMP-PKA pathway by dopamine acting at D1-like receptors in the frontal cortex is necessary for working memory.
Positive_regulation (activation) of PKA in frontal cortex associated with dopamine and urological neuroanatomy
6) Confidence 0.52 Published 2001 Journal Behav. Neurosci. Section Abstract Doc Link 11770052 Disease Relevance 0.18 Pain Relevance 0.43
When opioid withdrawal was precipitated, an increase in PKA immunoreactivity levels was observed 90 min after naloxone administration in the PVN and NTS/VLM areas.
Positive_regulation (increase) of PKA in PVN associated with medulla, narcan, withdrawal and opioid
7) Confidence 0.52 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15663473 Disease Relevance 0.53 Pain Relevance 1.61
Thus, although TTX-R INa is a common target for cellular processes involving the activation of either PKA or PKC, PKC activity is necessary to enable subsequent PKA-mediated modulation of TTX-R INa.
Positive_regulation (activation) of PKA associated with kinase c
8) Confidence 0.49 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.05 Pain Relevance 0.45
The protein levels of PKA, PKC delta and PKC zeta were significantly up-regulated in the heart from morphine withdrawal rats.
Positive_regulation (p-regulated ) of PKA in heart associated with kinase c, withdrawal and morphine
9) Confidence 0.48 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16202991 Disease Relevance 0 Pain Relevance 1.30
These results strongly suggest that a PKA mediated triggering and enhancement of SMPO may be responsible for the excitatory effects of NE on sensory neurons in neuropathic rats.
Positive_regulation (triggering) of PKA in sensory neurons associated with neuropathic pain
10) Confidence 0.47 Published 2003 Journal Pain Section Abstract Doc Link 14499434 Disease Relevance 0.33 Pain Relevance 0.38
When opioid withdrawal was precipitated, an increase in PKA immunoreactivity and phospho-CREB (cyclic AMP response element protein) levels were observed in the heart.
Positive_regulation (increase) of PKA in heart associated with withdrawal and opioid
11) Confidence 0.46 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17216288 Disease Relevance 0.17 Pain Relevance 1.44
Together, these results suggest that PKA activation within the vBNST via the enhancement of beta-adrenergic transmission is important for the negative affective component of pain.
Positive_regulation (activation) of PKA associated with pain
12) Confidence 0.45 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18667605 Disease Relevance 0.36 Pain Relevance 0.49
These results indicate that inhibition of PKA activation explains NSAIDs-induced decrease in adrenaline-stimulated lipolysis.
Positive_regulation (activation) of PKA associated with cinod
13) Confidence 0.45 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.46 Pain Relevance 1.02
If added before cAMP, NSAIDs impaired PKA activation by the cyclic nucleotide; however, if PKA was first activated by cAMP, NSAIDs were ineffective.
Positive_regulation (activated) of PKA associated with cinod
14) Confidence 0.45 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.49 Pain Relevance 1.03
Our results suggest that increased phosphorylation of the GluR1 subunit of AMPA receptors contributes to central sensitization following acute peripheral inflammation, and the effect may occur at different phosphorylation sites through the activation of the PKA or PKC protein kinase cascades.
Positive_regulation (activation) of PKA associated with kinase c, inflammation and central sensitization
15) Confidence 0.45 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559367 Disease Relevance 0.10 Pain Relevance 0.50
We examined whether 8-bromo-cAMP (8-Br-cAMP)-induced modification of tetrodotoxin-resistant (TTX-R) sodium current in neonatal rat nodose ganglion neurons is mediated by the activation of protein kinase A (PKA) and/or protein kinase C (PKC).
Positive_regulation (activation) of PKA in neurons associated with ganglion cysts, tetrodotoxin and kinase c
16) Confidence 0.38 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17140607 Disease Relevance 0.17 Pain Relevance 0.43
These results suggest that the 8-Br-cAMP-induced increase in Nav 1.8 currents may be mediated by activation of both PKA and PKC.
Positive_regulation (activation) of PKA associated with kinase c
17) Confidence 0.38 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17140607 Disease Relevance 0.07 Pain Relevance 0.24
Similar current changes after PKA activation were obtained from human embryonic kidney 293t cells transfected with the wild-type heat transducer protein vanilloid receptor 1 (VR-1).
Positive_regulation (activation) of PKA in embryonic kidney
18) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.47 Pain Relevance 0.53
For example, prostaglandins activate G(s)-protein-coupled receptors and initiate cAMP- and protein kinase A (PKA)-mediated processes.
Positive_regulation (initiate) of PKA
19) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.63 Pain Relevance 0.64
In dorsal horn neurons activation of PKA, PKC, or ERK increased neuronal excitability and inhibited transient potassium (A-type) currents.
Positive_regulation (activation) of PKA in neurons associated with neuronal excitability and dorsal horn neuron
20) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.63 Pain Relevance 1.00

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