INT52655

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Context Info
Confidence 0.23
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.09
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
T cell 2
dendritic cell 1
epithelial cells 1
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 156 100.00 Very High Very High Very High
Morphine 10 99.84 Very High Very High Very High
opioid receptor 1 98.80 Very High Very High Very High
agonist 15 90.48 High High
chemokine 14 90.40 High High
Inflammation 54 89.28 High High
depression 2 88.40 High High
Inflammatory stimuli 3 87.56 High High
cINOD 7 86.32 High High
rheumatoid arthritis 7 71.72 Quite High
Disease Link Frequency Relevance Heat
Death 2 98.56 Very High Very High Very High
Neuroblastoma 1 98.12 Very High Very High Very High
Infection 35 92.60 High High
INFLAMMATION 70 89.28 High High
Helminth Infection 25 89.04 High High
Depression 2 88.40 High High
Necrosis 4 88.36 High High
Cancer 6 88.00 High High
Immunization 10 81.68 Quite High
Disease 26 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of procaine on INa and IK are similar to SM486 but the effective concentration was higher.
Regulation (effects) of IK
1) Confidence 0.23 Published 1995 Journal Sheng Li Xue Bao Section Abstract Doc Link 7784895 Disease Relevance 0.09 Pain Relevance 0.11
The prototypical SK channel enhancer is 1-ethyl-2-benzimidazolinone (1-EBIO), first described as acting on native IK channels in colonic epithelial cells [63], and subsequently shown to enhance the activity of recombinant IK channels in transfected cell lines [64, 65].
Regulation (acting) of IK in epithelial cells
2) Confidence 0.08 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0
The enhancement of IL-12 at both the mRNA and protein levels was antagonized by naltrexone, indicating that the modulation of this cytokine by morphine is via a classic opioid receptor.
Regulation (modulation) of cytokine associated with opioid receptor, morphine and cytokine
3) Confidence 0.02 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.25 Pain Relevance 1.10
Our previous empirical results (Farley, 1988; Jin et al., 2009) indicate that combined changes in IA and IK(Ca) are required to substantially affect the SSGP in a manner that mimics the effects of paired (excitatory) behavioral training.
Regulation (changes) of IK
4) Confidence 0.01 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0
We evaluated the impact of Bv8 on lymphoid cells by investigating its ability to modulate T cell cytokine balance in mouse.


Spec (investigating) Regulation (modulate) of cytokine in T cell associated with cytokine
5) Confidence 0.01 Published 2008 Journal BMC Immunol Section Abstract Doc Link PMC2584092 Disease Relevance 0.17 Pain Relevance 0.35
Overall, our data indicate a dysregulation of the cytokine signaling pathway in the COX-2-/- mice, which may mediate the increased neuroinflammatory response.
Regulation (dysregulation) of cytokine associated with cytokine
6) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.60 Pain Relevance 0.46
A reduction (p < 0.05) of TH2 cytokine responses was observed from CD4+ T cells of SM-MHCCreIL-4R??
Regulation (responses) of cytokine in T cells associated with cytokine
7) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.63 Pain Relevance 0.21
In these studies, the nature of the specific P2 receptor subtype(s) responsible for the dendritic cell cytokine response was not addressed.While the above studies suggested that nucleotides may directly regulate cytokine output, more recent studies conducted with dendritic cells have focused on the role of extracellular nucleotides as modulators of cytokine output induced by other stimuli.
Spec (may) Regulation (regulate) of cytokine in dendritic cell associated with cytokine
8) Confidence 0.00 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.34 Pain Relevance 0.45

General Comments

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