INT52656

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.76
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
endothelial cells 1
blood vessel 1
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 142 100.00 Very High Very High Very High
cytokine 83 100.00 Very High Very High Very High
MU agonist 3 99.36 Very High Very High Very High
Opioid 15 99.00 Very High Very High Very High
rheumatoid arthritis 72 98.44 Very High Very High Very High
Inflammatory mediators 10 98.20 Very High Very High Very High
Neuritis 7 97.20 Very High Very High Very High
depression 2 96.46 Very High Very High Very High
Paracetamol 2 95.72 Very High Very High Very High
Kappa opioid receptor 9 94.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 163 100.00 Very High Very High Very High
Gram Positive Bacterium Infection 1 99.38 Very High Very High Very High
Experimental Autoimmune Neuritis 7 99.12 Very High Very High Very High
Vibrio Infection 3 99.08 Very High Very High Very High
Rheumatoid Arthritis 72 98.44 Very High Very High Very High
Infection 10 97.88 Very High Very High Very High
Bordatella Infection 3 97.20 Very High Very High Very High
Autoimmune Disease 8 97.04 Very High Very High Very High
Depression 2 96.46 Very High Very High Very High
Hyperemia 2 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed: (1) Both IK and INa were depressed in a dose-dependent manner, although the minimal effective concentration of SM486 for IK was lower than that for INa; (2) The depression was reversible as shown by the fact that the nearly completely blocked INa and IK currents could be restored to the control by simply washing away the perfusate SM486. (3) The decrease of IK was progressive, while the change of INa always began after IK proceeded to decrease rapidly.
Negative_regulation (decrease) of IK associated with depression
1) Confidence 0.57 Published 1995 Journal Sheng Li Xue Bao Section Abstract Doc Link 7784895 Disease Relevance 0.10 Pain Relevance 0.12
The results showed: (1) Both IK and INa were depressed in a dose-dependent manner, although the minimal effective concentration of SM486 for IK was lower than that for INa; (2) The depression was reversible as shown by the fact that the nearly completely blocked INa and IK currents could be restored to the control by simply washing away the perfusate SM486. (3) The decrease of IK was progressive, while the change of INa always began after IK proceeded to decrease rapidly.
Negative_regulation (decrease) of IK associated with depression
2) Confidence 0.37 Published 1995 Journal Sheng Li Xue Bao Section Abstract Doc Link 7784895 Disease Relevance 0.09 Pain Relevance 0.11
On the other hand, after chronic treatment with pertussis toxin (PTX), the usual microM opioid-induced increases in IK no longer occurred and more than half of the cells responded with a sustained decrease of IK to microM as well as nM opioids.
Negative_regulation (decrease) of IK associated with bordatella infection and opioid
3) Confidence 0.28 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.33 Pain Relevance 0.95
Low concentrations (< nM) usually elicited a transient increase in IK (within 1 min), followed by a sustained decrease in IK.
Negative_regulation (decrease) of IK
4) Confidence 0.28 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.33 Pain Relevance 0.79
After brief treatment with cholera toxin subunit B (CTX-B), the usual sustained decrease in IK evoked by < nM opioid agonists no longer occurred.
Negative_regulation (decrease) of IK associated with mu agonist and vibrio infection
5) Confidence 0.21 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.35 Pain Relevance 0.88
In the specific case of the EDHF-dependent blood vessel relaxation, in cerebral vessels it has been shown that inhibition of IK channels alone is sufficient to prevent EDHF-dependent relaxation and hyperpolarization [185, 186].
Negative_regulation (inhibition) of IK in blood vessel
6) Confidence 0.13 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.19 Pain Relevance 0
Thus, in peripheral vessels, it has been shown that EDHF-mediated responses are abolished by the combined inhibition of both SK and IK channels [178] that are expressed exclusively in endothelial cells [181, 183, 184].
Negative_regulation (inhibition) of IK in endothelial cells
7) Confidence 0.06 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.15 Pain Relevance 0
Soluble cytokine receptors may be shed naturally from cell membranes to inhibit cytokine activity.
Negative_regulation (inhibit) of cytokine associated with cytokine
8) Confidence 0.02 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 12609491 Disease Relevance 1.14 Pain Relevance 0.62
Tenidap, a compound reported to inhibit 5-lipoxygenase, cyclooxygenase and cytokine production, also stimulated TNF alpha production while the 5-lipoxygenase inhibitor, phenidone, was inactive.
Negative_regulation (inhibit) of cytokine associated with cytokine
9) Confidence 0.01 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.65 Pain Relevance 0.69
In addition, sTLR2 can blunt immune responses without preventing microbial recognition: mice injected with Gram positive bacteria together with sTLR2 exhibited reduced inflammatory cytokine levels and cell migration but this did not compromise their ability to clear live Gram-positive bacteria-induced infection [199].
Negative_regulation (reduced) of cytokine associated with gram positive bacterium infection, inflammation, infection and cytokine
10) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.94 Pain Relevance 0.31
By utilizing an in vitro bioassay in which TNF production can be evaluated, compounds from natural products directed at inhibiting this cytokine can be identified.
Negative_regulation (inhibiting) of cytokine associated with cytokine
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.66 Pain Relevance 0.47
However, the continuous and systemic blockade of a cytokine results in unwanted side effects, such as increased infections.
Negative_regulation (blockade) of cytokine associated with infection and cytokine
12) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.84 Pain Relevance 0.46

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