INT52657

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Context Info
Confidence 0.80
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 6.36
Pain Relevance 10.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 4
neurons 3
visceral 1
medulla 1
brain 1
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 20 99.96 Very High Very High Very High
Spinal cord 55 99.90 Very High Very High Very High
analgesia 10 99.78 Very High Very High Very High
transcutaneous nerve stimulation 21 99.58 Very High Very High Very High
Intracerebroventricular 4 99.56 Very High Very High Very High
Pain 25 99.44 Very High Very High Very High
electroacupuncture 13 99.44 Very High Very High Very High
anesthesia 5 99.42 Very High Very High Very High
Dorsal horn neuron 11 99.40 Very High Very High Very High
Stimulus evoked pain 6 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 21 99.44 Very High Very High Very High
Hypersensitivity 11 99.40 Very High Very High Very High
Hyperalgesia 26 99.26 Very High Very High Very High
Inflammatory Pain 4 99.06 Very High Very High Very High
Neuritis 12 98.36 Very High Very High Very High
Hypertension 2 97.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 96.80 Very High Very High Very High
Nociception 30 96.16 Very High Very High Very High
Drug Dependence 3 94.48 High High
INFLAMMATION 13 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rats were killed 2 h after the formalin injection, and the lumbar spinal cord was stained for c-fos or the phosphorylated NMDA receptor immunohistochemically.
Phosphorylation (phosphorylated) of c-fos in spinal cord associated with nmda receptor and spinal cord
1) Confidence 0.80 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12401615 Disease Relevance 0.25 Pain Relevance 0.45
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Phosphorylation (phosphorylated) of c-Fos in brain associated with glutamate, nmda receptor, narcan and withdrawal
2) Confidence 0.79 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.35 Pain Relevance 0.92
At 60 min after the termination of EA stimulation, the levels of c-fos, serine phosphorylation of NR1 and NR2B by Western analysis had increased in the L(4-5) segments of the spinal cord after EA treatment.
Phosphorylation (phosphorylation) of c-fos in spinal cord associated with electroacupuncture and spinal cord
3) Confidence 0.79 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.79
Immunohistochemical analysis found that the brain response to formalin injection was also more sensitive in middle-aged rats than young rats; a significant increase in the number of c-Fos immunoreactive cells was found in the ventral portion of the lateral septum of middle-aged rats injected with formalin compared to young and middle-aged rats injected with saline, irrespective of estrous cyclicity.
Phosphorylation (number) of c-Fos in ventral
4) Confidence 0.79 Published 2010 Journal Physiol. Behav. Section Abstract Doc Link 20156467 Disease Relevance 0.40 Pain Relevance 0.08
To investigate the analgesic effects of xenon, we performed formalin tests in rats under 0.5 minimum alveolar anesthetic concentration xenon or nitrous oxide and stained the lumbar spinal cord for c-fos (n = 18) and the phosphorylated N-methyl-D-aspartate (NMDA) receptor (n = 24) by using the avidin-biotin-peroxidase method.
Phosphorylation (phosphorylated) of c-fos in spinal cord associated with analgesic and spinal cord
5) Confidence 0.61 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12401615 Disease Relevance 0.14 Pain Relevance 0.29
Both formalin-evoked CREB phosphorylation and c-Fos expression in the spinal cord were suppressed by pretreatment with the NMDA receptor antagonist MK-801 (3.5 mg/kg, i.p.) or halothane anesthesia.
Phosphorylation (phosphorylation) of c-Fos in spinal cord associated with anesthesia, nmda receptor antagonist, halothane and spinal cord
6) Confidence 0.61 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.56 Pain Relevance 0.80
Effects of complete Freund's adjuvant (CFA)-induced inflammatory pain hypersensitivity and TENS analgesia on ERK1/2 phosphorylation and c-Fos protein expression were examined by using behavioral test, Western blot, and immunostaining methods.
Spec (examined) Phosphorylation (phosphorylation) of c-Fos associated with hypersensitivity, stimulus evoked pain, inflammatory pain, transcutaneous nerve stimulation and analgesia
7) Confidence 0.61 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.80 Pain Relevance 1.07
Transcutaneous electrical nerve stimulation on Yongquan acupoint reduces CFA-induced thermal hyperalgesia of rats via down-regulation of ERK2 phosphorylation and c-Fos expression.
Phosphorylation (phosphorylation) of c-Fos in nerve associated with thermal hyperalgesia and transcutaneous nerve stimulation
8) Confidence 0.61 Published 2010 Journal Anat Rec (Hoboken) Section Title Doc Link 20583264 Disease Relevance 0.72 Pain Relevance 1.04
On the other hand, the up-regulated CREB phosphorylation or c-fos induction evoked in the dorsomedial medulla by baroreceptor activation was significantly antagonized by NTS application of a cell-permeable cGMP antagonist, (R)p-8-bromoguanosine-3',5'-cyclic monophosphorothioate (5 nmol), or a PKG inhibitor, (8R,9S,11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy-1H,8H,11H,-2,7b,11a-trizadizo-benzo(a,g)cycloocta(c,d,e)-trinden-1-one (1 nmol).
Phosphorylation (phosphorylation) of c-fos in medulla associated with medulla and antagonist
9) Confidence 0.61 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14742673 Disease Relevance 0.07 Pain Relevance 0.18
These results suggest that down-regulation of ERK2 phosphorylation and c-Fos expression were involved in TENS inhibition on CFA-induced thermal hyperalgesia of rats.
Phosphorylation (phosphorylation) of c-Fos associated with thermal hyperalgesia and transcutaneous nerve stimulation
10) Confidence 0.61 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.70 Pain Relevance 1.16
The increase in ERK phosphorylation and Fos expression in the spinal cord dorsal horn neurons indicates that responses/activation by the noxious stimulation applied to the periphery were elevated in spinal cord neurons in this neuritis model of the lumbar nerve root.
Phosphorylation (phosphorylation) of Fos in spinal cord dorsal horn associated with neuritis, dorsal horn neuron and spinal cord
11) Confidence 0.61 Published 2003 Journal Brain Res. Section Abstract Doc Link 12650969 Disease Relevance 0.31 Pain Relevance 0.74
In order to elucidate the dorsal horn responsiveness to noxious stimulation to the peripheral tissue in the neuritis model of the nerve root, we examined extracellular signal-regulated kinase (ERK) phosphorylation and Fos expression in spinal cord dorsal horn neurons.
Spec (examined) Phosphorylation (phosphorylation) of Fos in neurons associated with dorsal horn, dorsal horn neuron, neuritis and spinal cord
12) Confidence 0.61 Published 2003 Journal Brain Res. Section Abstract Doc Link 12650969 Disease Relevance 0.32 Pain Relevance 0.49
Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root.
Phosphorylation (phosphorylation) of Fos in dorsal horn associated with neuritis and dorsal horn neuron
13) Confidence 0.61 Published 2003 Journal Brain Res. Section Title Doc Link 12650969 Disease Relevance 0.33 Pain Relevance 0.49
The present findings suggest that tooth-pulp-driven neurons in the spinal trigeminal nucleus are involved in tooth pulp pain through activation of the intracellular signal transduction pathway that involves earlier ERK phosphorylation and subsequent Fos expression.
Phosphorylation (phosphorylation) of Fos in tooth pulp associated with pain
14) Confidence 0.55 Published 2006 Journal Brain Res. Section Abstract Doc Link 16442086 Disease Relevance 0.15 Pain Relevance 0.39
The incision-induced increase in the number of Fos-LI neurons in the ipsilateral lamina V of rats from the group ASI was less intense after methysergide (30 ?
Phosphorylation (number) of Fos in lamina
15) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2860347 Disease Relevance 0 Pain Relevance 0.08
We have previously reported an increase in striatal immunoreactivity for P-CREB (phosphorylated on Ser-133) and Fos following intracerebroventricular (ICV) injection of H2O-soluble forskolin, a direct activator of adenylate cyclase.
Phosphorylation (phosphorylated) of Fos associated with intracerebroventricular
16) Confidence 0.42 Published 1995 Journal Synapse Section Abstract Doc Link 7784955 Disease Relevance 0 Pain Relevance 0.27
Two hours after induction, phosphorylated NR1, NR1, and Fos expressions were studied in TNC by immunohistochemistry.
Phosphorylation (phosphorylated) of Fos
17) Confidence 0.36 Published 2009 Journal Headache Section Body Doc Link 19220502 Disease Relevance 0.15 Pain Relevance 0
Following electrical intracochlear stimulation with a cochlear implant under urethane anesthesia, we observed changes in the phosphorylation state of the cAMP response element binding protein (CREB) and the expression of the immediate-early genes c-fos and egr-1, molecules known to act as transcription factors, in a tonotopically precise pattern in central auditory neurons.
Phosphorylation (phosphorylation) of c-fos in neurons associated with anesthesia
18) Confidence 0.35 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12009775 Disease Relevance 0 Pain Relevance 0.17
This study aimed to evaluate the effects of pre-electroacupuncture on pain behaviors, p38 phosphorylation, and c-Fos protein and mRNA expression in both the colonic wall and spinal dorsal horn of rats suffering from visceral pain.
Phosphorylation (phosphorylation) of c-Fos protein in visceral associated with pain, visceral pain, spinal dorsal horn and electroacupuncture
19) Confidence 0.30 Published 2010 Journal Chin. Med. J. Section Abstract Doc Link 20529559 Disease Relevance 0.19 Pain Relevance 0.85
To elucidate how noxious stimuli may regulate ppENK transcription in these neurons, we have in the present study investigated whether immunoreactivity for the transcription factors FOS and phosphorylated CREB (pCREB), respectively, is displayed in the ppENK mRNA-expressing neurons after peripheral nociceptive stimulation.
Phosphorylation (phosphorylated) of FOS in neurons associated with nociception
20) Confidence 0.21 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9427521 Disease Relevance 0.30 Pain Relevance 0.17

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